1 Result for "

SA09-Cu

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "SA09-Cu" in MCE Product Catalog:

Cat. No.: HY-150260
CAS No.: 155641-16-0
Target:  

Bacterial

Research Areas:  

Infection

SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance .
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