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Results for "

SK-OV-3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Akt (2) Antifolate (1) Apoptosis (22) Autophagy (1) Bcl-2 Family (3) c-Myc (1) Cadherin (1) Caspase (2) CDK (2) Cytochrome P450 (1) DNA/RNA Synthesis (2) Drug Derivative (4) Drug Intermediate (1) Drug Isomer (2) Drug-Linker Conjugates for ADC (1) EGFR (4) Endogenous Metabolite (1) ERK (1) Eukaryotic Initiation Factor (eIF) (1) FAK (2) Ferroptosis (2) Folate Receptor (FR) (1) Glutaminase (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (2) HIV (1) HSP (2) Indoleamine 2,3-Dioxygenase (IDO) (5) Integrin (1) Interleukin Related (1) IRAK (1) Kinesin (1) LPL Receptor (2) MAP4K (1) MDM-2/p53 (1) METTL3 (1) Microtubule/Tubulin (8) Mitochondrial Metabolism (1) Mitosis (1) MMP (3) mTOR (1) NAMPT (1) NF-κB (2) PAK (1) Paraptosis (1) Parasite (1) PARP (4) PERK (1) Phosphatase (1) PI3K (2) PROTACs (3) Ras (1) Reactive Oxygen Species (ROS) (3) SHMT (1) Src (2) TGF-β Receptor (1) TNF Receptor (1) Topoisomerase (1) TRP Channel (1) Tyrosinase (1) VEGFR (1)
By Research Areas:	Cancer (74) Infection (2) Inflammation/Immunology (2) Neurological Disease (1)

By Targets:

ADC Payload (1)

Akt (2)

Antifolate (1)

Apoptosis (22)

Autophagy (1)

Bcl-2 Family (3)

c-Myc (1)

Cadherin (1)

Caspase (2)

CDK (2)

Cytochrome P450 (1)

DNA/RNA Synthesis (2)

Drug Derivative (4)

Drug Intermediate (1)

Drug Isomer (2)

Drug-Linker Conjugates for ADC (1)

EGFR (4)

Endogenous Metabolite (1)

ERK (1)

Eukaryotic Initiation Factor (eIF) (1)

FAK (2)

Ferroptosis (2)

Folate Receptor (FR) (1)

Glutaminase (1)

HDAC (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Methyltransferase (2)

HIV (1)

HSP (2)

Indoleamine 2,3-Dioxygenase (IDO) (5)

Integrin (1)

Interleukin Related (1)

IRAK (1)

Kinesin (1)

LPL Receptor (2)

MAP4K (1)

MDM-2/p53 (1)

METTL3 (1)

Microtubule/Tubulin (8)

Mitochondrial Metabolism (1)

Mitosis (1)

MMP (3)

mTOR (1)

NAMPT (1)

NF-κB (2)

PAK (1)

Paraptosis (1)

Parasite (1)

PARP (4)

PERK (1)

Phosphatase (1)

PI3K (2)

PROTACs (3)

Ras (1)

Reactive Oxygen Species (ROS) (3)

SHMT (1)

Src (2)

TGF-β Receptor (1)

TNF Receptor (1)

Topoisomerase (1)

TRP Channel (1)

Tyrosinase (1)

VEGFR (1)

By Research Areas:

Cancer (74)

Infection (2)

Inflammation/Immunology (2)

Neurological Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15650

SGC0946 Maximum Cited Publications 12 Publications Verification	Histone Methyltransferase	Cancer
SGC0946 is a selective DOT1L inhibitor with an IC₅₀ value of 0.3 nM. By inhibiting DOT1L, SGC0946 can induce G1 phase arrest, suppress cell self-renewal and metastatic potential, and induce cell differentiation in cancer cells. SGC0946 can be used in the research of tumors such as leukemia and breast cancer, and also serves as a probe to further investigate the cellular mechanisms of DOT1L in normal and diseased cells ^[3].

HY-116147

Ceranib-2	LPL Receptor Apoptosis	Cancer
Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC₅₀ of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity .

HY-125847

Salvianolic acid F 1 Publications Verification	Ras PI3K Akt Caspase Apoptosis Bcl-2 Family NF-κB MMP	Cancer
Salvianolic acid F is a KRAS inhibitor, especially for KRAS G12D. Salvianolic acid F inhibits NF-kB, MMP-9, and NO simultaneously. Salvianolic acid F inhibits cancer cell growth, invasion, and migration and induces apoptosis via the EP300/PI3K/AKT pathway in vitro. Salvianolic acid F inhibits the growth of KRAS-dependent lung cancer cells via the *PI3K/AKT* signaling pathway in vivo. Salvianolic acid F can be used in the research of various cancers, including KRAS G12D-driven non-small cell lung cancer (NSCLC) and ovarian cancer .

HY-N2416

Taccalonolide A	Microtubule/Tubulin Apoptosis	Cancer
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities . Taccalonolide A causes G₂-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis . Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC₅₀ of 622 nM for SK-OV-3 cells ^[3].

HY-P99605

Cinrebafusp alfa PRS 343	EGFR TNF Receptor	Cancer
Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (K_d=0.3 nM) and human monomeric CD137 (4-1BB; K_d=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research .

HY-N3028

Taccalonolide B	Microtubule/Tubulin	Cancer
Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC₅₀ of 208 nM .

HY-122653A

CCT367766 formic	PROTACs	Cancer
CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC₅₀ value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with K_d values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein .

HY-134911

HS-243	IRAK CDK	Inflammation/Immunology Cancer
HS-243 is a potent and selective IRAK-4 and IRAK-1 inhibitor, with IC₅₀ values of 20 and 24 nM. HS-243 shows minimal TAK1 (transforming growth factor β-activated kinase 1) inhibition activity, with a IC₅₀ of 0.5 μM. HS-243 shows anti-inflammatory and anticancer activity .

HY-16191

ELR510444 1 Publications Verification	Microtubule/Tubulin Apoptosis HIF/HIF Prolyl-Hydroxylase Mitosis	Cancer
ELR510444 is an orally active tubulin inhibitor with an IC₅₀ of 10 μM. ELR510444 binds to the colchicine-binding site on β-tubulin, inhibits tubulin assembly, depolymerizes microtubules and blocks HIF activity. ELR510444 induces cellular microtubule loss, abnormal mitotic spindle, mitotic arrest, apoptosis, morphological changes in tumor endothelial cells, and inhibits cancer cell proliferation, angiogenesis and tumor growth. ELR510444 can be used in research related to various cancers such as renal cell carcinoma .

HY-177285

NVP-BQS481	Kinesin ADC Payload	Cancer
NVP-BQS481 (Compound 1) is a selective Kinesin spindle protein-5 (Eg5) inhibitor with an IC₅₀< 0.5 nM. NVP-BQS481 has significant antimitotic and antitumor activity (IC₅₀: 0.0.9 nM for SK-OV-3ip cells). NVP-BQS481 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .

HY-172970

HQY1428	CDK DNA/RNA Synthesis Apoptosis	Cancer
HQY1428 is an orally active CDK12 inhibitor. HQY1428 inhibits DNA replication, causes G2/M arrest in SKOV3 cells, induces DNA double-strand breaks and apoptosis. HQY1428 has anti-tumor activity in the SKOV3 xenograft mouse model. HQY1428 combined with the HER2 inhibitor Lapatinib (HY-50898) in the NCI-N87 xenograft mouse model produces a synergistic therapeutic effect .

HY-102073

TG53	Glutaminase Integrin FAK Src	Cancer
TG53 is a potent inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. TG53 inhibits formation of a complex with integrin β1 and activation of FAK and c-Src during SKOV3 cell attachment onto FN. TG53 can be used for ovarian cancer research .

HY-P1651B

SOR-C13 acetate 1 Publications Verification	TRP Channel	Cancer
SOR-C13 acetate is the acetate salt form of SOR-C13 (HY-P1651). SOR-C13 acetate is an antagonist for transient receptor potential vanilloid 6 (TRPV 6), with an IC₅₀ of 14 nM. SOR-C13 acetate inhibits tumor growth in SKOV-3 xenograft mouse model .

HY-N15314

Syringolin A	MDM-2/p53 Akt Apoptosis	Cancer
Syringolin A is a plant elicitor that can be produced by the plant pathogen Pseudomonas syringae pv. syringae. Syringolin A exhibits anti-proliferative activity against a variety of cancer cells (IC₅₀ for SK-N-SH, LAN-1, SKOV3 is 20-25 µM), induces apoptosis in SK-N-SH through upregulation of p53 expression and downregulation of Akt/PKB proteins .

HY-N3222

Myriceric acid B	HIV	Infection Cancer
Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41. Myriceric acid B is an antitumor agent .

HY-178446

METTL3-IN-11	METTL3 c-Myc Bcl-2 Family	Cancer
METTL3-IN-11 is an excellent, selective *METTL3* inhibitor (IC₅₀ = 45.31 nM). METTL3-IN-11 exhibits high selectivity towards METTL3 compared to DNMT1, EZH1, MLL1, and PRMT1. METTL3-IN-11 reduces the m6A level of total RNA in MOLM-13 and SKOV3 cells, induces cell apoptosis, and inhibits cell migration. METTL3-IN-11 can reduce the expression of m6A downstream target genes (c-MYC and BCL2). METTL3-IN-11 can be used for the study of ovarian cancer and acute myeloid leukemia .

HY-N8934

6β-Hydroxytomentosin	Others	Cancer
6β-Hydroxytomentosin, a sesquiterpenoid, can be found in flowers of Inula japonica. 6β-Hydroxytomentosin exhibits weak cytotoxicities against A549, SK-OV-3, HepG-2 and HT-29 cell lines .

HY-N6578

3-epi-Isocucurbitacin B	Others	Cancer
3-epi-Isocucurbitacin B (Compound 5) is a cucurbitane triterpene derived from Trichosanthes kirilowii. 3-epi-Isocucurbitacin B shows significant cytotoxicity to human tumor cells A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT15 .

HY-178948

HDAC10-IN-3	HDAC	Cancer
HDAC10-IN-3 (Compound 2a) is a potent HDAC10 inhibitor with an IC₅₀s of 0.41, 37, 350 and 4500 nM against HDAC10, HDAC6, HDAC8 and HDAC1. HDAC10-IN-3 exhibits moderate cytotoxicity in KB and SK-OV-3 cells, but does not show significant cytotoxicity against most cancer cell lines. HDAC10-IN-3 can be used for the study of cancers .

HY-146080

Antitumor agent-61	Apoptosis	Cancer
Antitumor agent-61 (Compound 9b), Irinotecan (Ir) derivative, is a potential antitumor agent. Antitumor agent-61 displays potent activity with IC₅₀s of 0.92, 1.39, 1.75, 2.20, 3.05 and 3.23 μM against five human cancer cells SK-OV-3, SK-OV-3/CDDP, U2OS, MCF-7, A549 and MG-63, respectively. Antitumor agent-61 induces SK-OV-3 cells apoptosis through mitochondrion pathways .

HY-N12821

visamminol-3'-O-glucoside	Others	Cancer
Visamminol-3'-O-glucoside (Compound 4) is a chromone glycoside, which is initially isolated from Saposhnikovia divaricata. Visamminol-3'-O-glucoside exhibits weak cytotoxicity against cancer cells PC-3, SK-OV-3 and H460, with IC₅₀s of 93.91, >100 and >100 μM, respectively .

HY-144273

IDO1-IN-13	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-13 (compound 27a) is a potent IDO1 inhibitor with an IC₅₀ of 61.6 nM. IDO1-IN-13 has cellular IDO1 inhibition (HeLa EC₅₀= 30 nM). IDO1-IN-13 decreases 51% of the kyn/trp ratio in SK-OV-3 xenograft tumor tissues .

HY-N3179

Norcepharadione B	Others	Others
Norcepharadione B is an alkaloid that can be isolated from Houttuynia cordata. Norcepharadione B exhibits moderate cytotoxicity against A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cell line with ED₅₀s of 40, 26.4, 40, 14.2 and 38.2 μg/mL, respectively .

HY-N3113

Panaxyne	Others	Cancer
Panaxyne is a polyacetylene, that can be isolated from the roots of cultivated-wild ginseng. Panaxyne shows significant and selective cytotoxicity against SK-OV-3, with an ED₅₀ of 1.40 µM .

HY-178956

KUNB106	HSP	Cancer
KUNB106 is a selective Hsp90β inhibitor with K_Ds of 91 nM and 38 μM against Hsp90β and Hsp90α. KUNB106 exhibits antiproliferative activity against MDA-MB-231 cells, A549 and SKOV-3 cells. KUNB106 can be used for the study of triple negative breast cancer .

HY-162537

LYP-8	PROTACs NAMPT	Cancer
LYP-8 is a potent and effective NAMPT degrader with maximum degradation of 97% at 0.5 μM in SKOV-3 cells. LYP-8 shows anti-cancer activity in vivo and in vitro(Sturcture Note:(Blue: Cereblon ligand (HY-112078), Black: linker (HY-128801)；Pink: Nampt inhibitor Nampt-IN-11 (HY-158689)) .

HY-159123

KHK-6	MAP4K	Cancer
KHK-6 is an inhibitor for serine/threonine kinase hematopoietic progenitor kinase 1 (HPK 1) with an IC₅₀ of 20 nM. KHK-6 enhances CD3/CD28-induced cytokine production, enhances CD69, CD25 and HLA-DR markers on CD4+ and CD8+ T cells, and enhances T cell-mediated killing activity of SKOV3 and A549 cells .

HY-175257

Theophylline-platinum(IV) prodrug-1	PARP Reactive Oxygen Species (ROS) Apoptosis NF-κB ERK Bcl-2 Family TGF-β Receptor EGFR Cadherin	Cancer
Theophylline-platinum(IV) prodrug-1 is a PARP-1 inhibitor. Theophylline-platinum(IV) prodrug-1 enhances DNA damage, ROS production, mitochondrial dysfunction, apoptosis and S-phase arrest, along with reducing invasion and metastasis in cells. Theophylline-platinum(IV) prodrug-1 exhibits superior antitumor activity in the xenograft SKOV3-BRCA1-KD tumor model. Theophylline-platinum(IV) prodrug-1 can be used for the study of ovarian cancer .

HY-N9101

4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan	Others	Cancer
4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan is a lignans that can be isolated from the Viburnum foetidum. 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan has cytotoxicity against A549, SK-OV-3, SKMEL-2 and HCT15 cell line with IC₅₀s of 67.14, 67.38, 64.11 and 76.31 μg/mL, respectively .

HY-N12589

8-epi-Helenalin	Others	Cancer
8-epi-Helenalin is a semitterpene lactone with anti-tumor activity that can be isolated from Inula britannicaL. var. chinensis (Rupr.) Reg. and the ED₅₀ values of 8-epi-Helenalin for HL-60, A549, MCF7, HCT-15, SK-OV-3 and Malme-3M are 12.2 μM, 53.8 μM, 9.1 μM, 8.7 μM, 18.7 μM and 8.3 μM, respectively. 8-epi-Helenalin can be used for anti-tumor studies .

HY-N11082

Isocucurbitacin D	Others	Cancer
Isocucurbitacin D is an antitumor agent .

HY-175466

BER-IN-1	PARP DNA/RNA Synthesis Apoptosis	Cancer
BER-IN-1 is a base excision repair (BER) inhibtor, targeting DNA abasic sites. BER-IN-1 cleaves abasic sites via β- and β,δ-elimination mechanisms, disrupts the base excision repair (BER) pathway and leads to DNA double-strand breaks (DSBs). BER-IN-1 can enhance the effectiveness of the PARP inhibitor Olaparib (HY-10162) in homologous recombination (HR)-proficient cancer cells (MDA-MB-231, HeLa, and SKOV3). BER-IN-1 induces an S-phase arrest and apoptosis companied with Olaparib (HY-10162). BER-IN-1 can be used for the research of cancer, such as breast, cervical and ovarian cancer .

HY-123898

Cepharadione B	Tyrosinase Endogenous Metabolite	Cancer
Cepharadione B (compound 22) is a natural compound isolated from the leaves of Piper sanctum. Cepharadione B is a tyrosinase inhibitor with an IC₅₀ value of 170 μM, and inhibits cell growth in A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cells ^[3].

HY-176539

PAK1-IN-2	PAK PERK	Cancer
PAK1-IN-2 (Compound 35) is a selective PAK1 inhibitor with a K_i of 7.3 nM. PAK1-IN-2 can inhibit MEK phosphorylation. PAK1-IN-2 has significant inhibitory effects on PAK1/4 amplified cancer cell lines. PAK1-IN-2 can be used in the study of cancer .

HY-N1614

1α-Hydroxytorilin	Others	Others
1 α-hydroxytorilin (compound 3) is a sesquiterpenoid. 1 α-hydroxytorilin can be isolated from Torilis japonica. 1α-hydroxytorilin has cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells with ED50 values of 20.52, 18.24, 17.48, 42.54 μg/mL, respectively .

HY-N12349

Glucozaluzanin C	Others	Others
Glucozaluzanin C is a lignan isolated from the MeOH extract of the roots of Ainsliaea acerifolia (Compositae). Glucozaluzanin C has ED₅₀ value of 2.45 μg/mL, 1.37μg/mL, 0.40 μg/mL, 1.41 μg/mL, 1.43 μg/mL for A549 cells, SK-OV-3 cells, SK-MEL-2 cells, XF498 cells, HCT15 cells, respectively .

HY-173515

FAK-IN-26	FAK	Cancer
FAK-IN-26 is a BBB-penetrable Focal Adhesion Kinase (FAK) inhibitor (IC₅₀: 0.87 nM). FAK-IN-26 significantly suppresses tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 has potent anti-cancer activity in A549 and SKOV-3 tumor mice models with tumor inhibition rates of 59.15 % and 57.9 % .

HY-178325

Tubulin-IN-57	Microtubule/Tubulin Apoptosis	Cancer
Tubulin-IN-57 is a Tubulin inhibitor. Tubulin-IN-57 is a potent antiproliferative agent that inhibits clonogenic formation, migration, and invasion of ovarian cancer cells. Tubulin-IN-57 inhibits tubulin polymerization, which in turn induces G2/M arrest and apoptosis in SKOV3 cells. Tubulin-IN-57 demonstrates potent antitumor activity without observable toxicity in an SKOV3 xenograft model. Y60S can be used for the study of ovarian cancer .

HY-135725

D-69491 hydrochloride	EGFR	Cancer
D-69491 hydrochloride is a HER-2 tyrosine kinase inhibitor that reduces HER-2 phosphorylation, inhibits the proliferation of SKOV-3 cells, and has anticancer activity .

HY-169062

RJF02215	MMP	Cancer
RJF02215 is an MMP-9 inhibitor. RJF02215 has growth-inhibitory activity on the ovarian cancer SKOV3 cell line. RJF02215 can be used for tumor research .

HY-139882

Anticancer agent 16	Reactive Oxygen Species (ROS) Apoptosis	Cancer
Anticancer agent 16 exhibits good cytotoxic activity against HCT-116, NCI-H460, and SKOV3 cell lines with IC₅₀ 8.55 μΜ, 5.41 μΜ, and 6.4 μΜ, respectively.

HY-164320

Anticancer agent 245	Apoptosis	Cancer
Anticancer agent 245 (Compound 115) inhibits proliferation of cancer cell SKOV3, MDA-MB-231 and HCT-116 with IC₅₀ of 0.021, 0.056 and 0.11 μM, respectively. Anticancer agent 245 exhibits antitumor efficacy in mice and good pharmacokinetic characteristics in rat models .

HY-161824

Antiproliferative agent-52	Drug Intermediate	Cancer
Antiproliferative agent-52 (Compound 4a) is an antiproliferative agent that exhibits significant antiproliferative activity against four human tumor cell lines (A549, A2780, SKOV3, HCC827), with IC₅₀ values ranging from 5.83 to 8.63 nM. Antiproliferative agent-52 can be used in cancer research .

HY-134583

IDO1-IN-7	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC₅₀ of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer .

HY-161845

Anticancer agent 240	Drug Derivative	Cancer
Anticancer agent 240 (compound 9b) is an 8-quinolinesulfonamide derivative with a cytotoxicity activity. Anticancer agent 240 shows inhibitory activity in Caco-2, SNB-19, A-549, and SKOV-3 cell line IC₅₀ values of 0.26, 0.38, 0.40 and 4.16 μM .

HY-144808

Anticancer agent 40	Microtubule/Tubulin	Cancer
Anticancer agent 40 (compound 3e) is a potent anticancer agent. Anticancer agent 40 shows anticancer activities with IC₅₀s of 0.94, 0.98, 0.96, 0.95, 2.13 nM for SKBR-3, SKOV-3, PC-3, U-87, HDF cells, respectively .

HY-119110

LY52	MMP	Cancer
LY52 is an MMP-2 and MMP-9 inhibitor. LY52 can significantly block the proteolytic activity of gelatinases, reducing the expression of MMP-2 and MMP-9 in SKOV3 cells, thereby inhibiting cell invasion. LY52 can also suppress the pulmonary metastasis of Lewis lung carcinoma cells in mice. LY52 may be used in cancer research .

HY-149717

Antitumor agent-122	Ferroptosis Apoptosis Autophagy	Cancer
Antitumor agent-122 (Compound 5j) is an antitumor agent with good efficacy, limited toxicity and low resistance. Antitumor agent-122 has antiproliferative activity for MGC-803 cell, HepG2 cell, SKOV3 cell and T24 cell with IC₅₀ values of 5.23 μM, 3.60 μM, 1.43 μM, 3.03 μM, respectively .

HY-178957

Hsp90β-IN-2	HSP	Cancer
Hsp90β-IN-2 (Compound 16B) is a selective Hsp90β inhibitor with K_Ds of 225 nM and 73.32 μM against Hsp90β and Hsp90α. KUNB106 exhibits antiproliferative activity against MDA-MB-231 cells, A549 and SKOV-3 cells. KUNB106 can be used for the study of triple negative breast cancer .

HY-161473

Apoptosis inducer 16	Apoptosis	Cancer
Apoptosis inducer 16 (Compound 3) is a bivalent Smac mimic that can effectively bind to BIR2 and BIR3, and exhibits cancer cell (apoptosis) inducing activity .

Cat. No.	Product Name	Target	Research Area

HY-P1651B

SOR-C13 acetate 1 Publications Verification	TRP Channel	Cancer
SOR-C13 acetate is the acetate salt form of SOR-C13 (HY-P1651). SOR-C13 acetate is an antagonist for transient receptor potential vanilloid 6 (TRPV 6), with an IC₅₀ of 14 nM. SOR-C13 acetate inhibits tumor growth in SKOV-3 xenograft mouse model .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99605

Cinrebafusp alfa PRS 343	EGFR TNF Receptor	Cancer
Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (K_d=0.3 nM) and human monomeric CD137 (4-1BB; K_d=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research .

HY-P991310

Lpathomab LT3015; LT-3000	LPL Receptor	Neurological Disease Cancer
Lpathomab (LT3015; LT-3000) is a human IgG1 monoclonal antibody (mAb) targeting LPA. Lpathomab reduces the release of IL-8 and IL-6 cytokines in SKOV3 cells and blocks LPA-triggered tumor cell migration. Lpathomab reduces neovascularization in Matrigel plug and CNV models. Lpathomab inhibits brain injury in the CCI mouse model. Lpathomab can be used in the study of brain injury, ovarian cancer, diabetic neuropathy, and spinal cord injury. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

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