1402830-75-4
Chemical Structure
Ceranib-2
- CAS No.: 1402830-75-4
- Formula:C25H19NO3
- Molecular Weight:381.42
IUPAC Name: (E)-3-(3-(4-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one
InChIKey: YIJGNIIQDRGGFT-DTQAZKPQSA-N
SMILES: O=C1NC(C=CC=C2)=C2C(C3=CC=CC=C3)=C1C(/C=C/C4=CC=C(C=C4)OC)=O
Biological Activity: Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity[1][2].
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Ceranib-2 | 98.92% | Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity. | ||||||||||||||||||||
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- [1]. Draper JM, et al. Discovery and evaluation of inhibitors of human ceramidase. Mol Cancer Ther. 2011 Nov;10(11):2052-61. [Content Brief]
- [2]. Kus G, et al. Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2. In Vitro Cell Dev Biol Anim. 2015 Nov;51(10):1056-63. [Content Brief]
Keywords
