2. PI3K/Akt/mTOR
  3. Akt
  4. BI-69A11

BI-69A11 is an AKT inhibitor that can effectively suppress the phosphorylation of AKT. BI-69A11 exhibits anticancer activity and can lead to the death of melanoma cells and prostate tumor cells.

For research use only. We do not sell to patients.

BI-69A11

BI-69A11 Chemical Structure

CAS No. : 1233322-09-2

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Based on 1 publication(s) in Google Scholar

BI-69A11 Related Antibodies

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Akt Akt1 Akt2 Akt3

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Description

BI-69A11 is an AKT inhibitor that can effectively suppress the phosphorylation of AKT. BI-69A11 exhibits anticancer activity and can lead to the death of melanoma cells and prostate tumor cells[1].

Molecular Weight

425.87

Formula

C25H16ClN3O2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C1NC2=C(C=C(Cl)C=C2)C(C3=CC=CC=C3)=C1C(/C=C/C4=NC5=CC=CC=C5N4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 55 mg/mL (129.15 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3481 mL 11.7407 mL 23.4813 mL
5 mM 0.4696 mL 2.3481 mL 4.6963 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3481 mL 11.7407 mL 23.4813 mL 58.7034 mL
5 mM 0.4696 mL 2.3481 mL 4.6963 mL 11.7407 mL
10 mM 0.2348 mL 1.1741 mL 2.3481 mL 5.8703 mL
15 mM 0.1565 mL 0.7827 mL 1.5654 mL 3.9136 mL
20 mM 0.1174 mL 0.5870 mL 1.1741 mL 2.9352 mL
25 mM 0.0939 mL 0.4696 mL 0.9393 mL 2.3481 mL
30 mM 0.0783 mL 0.3914 mL 0.7827 mL 1.9568 mL
40 mM 0.0587 mL 0.2935 mL 0.5870 mL 1.4676 mL
50 mM 0.0470 mL 0.2348 mL 0.4696 mL 1.1741 mL
60 mM 0.0391 mL 0.1957 mL 0.3914 mL 0.9784 mL
80 mM 0.0294 mL 0.1468 mL 0.2935 mL 0.7338 mL
100 mM 0.0235 mL 0.1174 mL 0.2348 mL 0.5870 mL
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BI-69A11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI-69A111233322-09-2AktPKBProtein kinase Bxenograft melanomamelanomatumor of prostateanticancer activityInhibitorinhibitorinhibit

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