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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

SMMC-7721 cells

" in MedChemExpress (MCE) Product Catalog:

標的別:	Acetyl-CoA Carboxylase (1) ADC Payload (1) Amylases (1) Apoptosis (12) Bcl-2 Family (2) Caspase (2) CDK (1) Cytochrome P450 (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (1) Drug Derivative (4) Drug Intermediate (1) EGFR (3) Epigenetic Reader Domain (1) ERK (1) Fatty Acid Synthase (FASN) (1) Fluorescent Dye (3) HMG-CoA Reductase (HMGCR) (1) HSP (1) JNK (1) Liposome (1) PARP (1) PI3K (1) PTEN (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) SARS-CoV (1) STAT (1) Topoisomerase (2) TrxR (1) γ-Glutamyl Transferase (GGT) (1)
研究分野別:	Cancer (37) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (3)
Oligonucleotides:	Pegylated Lipids (1) Aptamers (2)

阻害剤およびアゴニスト

蛍光色素

生化学アッセイ試薬

ペプチド

阻害性抗体

天然物

オリゴヌクレオチド

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

製品番号	製品名	Target	研究分野	構造式

HY-P11308

Cys-GE11	EGFR	Cancer
Cys-GE11 is an N-terminal modified GE11 (HY-P10128) with cysteine (Cys) added. Cys-GE11 can be coupled through the thiol group of Cys. Cys-GE11 can be linked to PEG-P (TMC-DTC) through the N-terminus of cysteine to form a targeted polymer. Cys-GE11 can target cells with high EGFR expression (such as SMMC-7721 cells). Cys-GE11 can significantly enhance drug enrichment at the tumor site and exhibit low toxicity .

HY-N2116

Ginkgolic acid C17:1 1 Publications Verification	PTEN Fatty Acid Synthase (FASN) STAT Apoptosis SARS-CoV	Infection Cancer
Ginkgolic acid C17:1 is a fatty acid synthase (FAS) inhibitor with an IC₅₀ of 10.5 µM. Ginkgolic acid C17:1 shows anti-tumor activity by inhibiting the phosphorylation of STAT3 and inducing apoptosis. Ginkgolic acid C17:1 can block the interaction between S-RBD and ACE2, and has anti-SARS-CoV-2-S pseudovirus activity. Ginkgolic acid C17:1 inhibits the biofilm formation of enterohemorrhagic Escherichia coli and Staphylococcus aureus .

HY-172470

DSPE-PEG2000-GE11	Liposome EGFR	Cancer
DSPE-PEG2000-GE11 is a nanocarrier component composed of DSPE and the EGFR-targeting peptide (GE11). DSPE-PEG2000-GE11 specifically binds to EGFR and mediates receptor-mediated endocytosis of micellar drug carriers. DSPE-PEG2000-GE11 can be used for drug delivery .

HY-N7022

Eclalbasaponin I	Others	Cancer
Eclalbasaponin I is isolated from Eclipta prostrata L with antitumor activity. Eclalbasaponin I inhibits the proliferation of hepatoma cell smmc-7721 with an IC₅₀ value of 111.1703 μg/ml .

HY-N4048

Heudelotinone	Others	Cancer
Heudelotinone is a dinorditerpenoid that can be isolated from the stem bark and roots of Ricinodendron heudelotii. Heudelotinone shows cytotoxicity against SMMC-7721, A549 and Hela cells with IC₅₀s of 21.68, 16.04 and 10.67 μM, respectively .

HY-W106860

9H-Carbazole-3-carbaldehyde	Drug Intermediate	Cancer
9H-Carbazole-3-carbaldehyde is an anticancer agent that can be isolated from the stems of Lansium parasiticum (Lour.) Skeels. 9H-Carbazole-3-carbaldehyde shows significant cytotoxic activity in a variety of tumor cell lines, especially against H1299 and SMMC-7721 lung cancer cells with IC₅₀ values of 6.19-26.84 μg/mL .

HY-146350

TrxR-IN-4	TrxR Reactive Oxygen Species (ROS) Apoptosis	Cancer
TrxR-IN-4 is a thioredoxin reductase (TrxR) inhibitor with a rat IC₅₀ of 0.37 μM. TrxR-IN-4 inhibits TrxR activity, elevates reactive oxygen species (ROS) and induces apoptosis. TrxR-IN-4 mediates endoplasmic reticulum stress and induces mitochondrial dysfunction. TrxR-IN-4 can be used for the research of hepatocellular carcinoma .

HY-N2570

Corytuberine	Others	Cancer
Corytuberine is an aporphine alkaloid found in Dicranostigma leptopodum. Corytuberine displays cytotoxicity against SMMC-7721 tumor cells .

HY-N16067

Penipanoid C	Epigenetic Reader Domain	Inflammation/Immunology
Penipanoid C (Compound 9) is a BRD4 inhibitor. Penipanoid C can be isolated from marine sediment-derived fungus Penicillium paneum SD-44. Penipanoid C has anti-inflammatory activity and cytotoxic activity against the SMMC-7721 cells. Penipanoid C can be used for inflammatory diseases research .

HY-131055

Mytoxin B	ADC Payload PI3K Apoptosis	Cancer
Mytoxin B is an ADC cytotoxin. Mytoxin B is a satratoxin-type trichothecene macrolide and is similar to the effect of LY294002 (HY-10108). Mytoxin B induces cell apoptosis via PI3K/Akt pathway .

HY-122944

20-Deoxocarnosol	Others	Cancer
20-Deoxocarnosol (compound 7) is a potent anti-cancer agent that can be found in the roots of Salvia deserta. 20-Deoxocarnosol shows cytotoxicity in cancer cells .

HY-178918

XZA-1	Acetyl-CoA Carboxylase	Cancer
XZA-1 is a 3-hydroxyacyl-coenzyme A dehydrogenase (HADH) activator. XZA-1 increases the intracellular level of acetoacetyl-CoA, which in turn induces acetoacetylation modification of Chromobox Protein Homolog 4 (CBX4) at lysine 106 (K106). XZA-1 exhibits antitumor effects in a xenograft model of human hepatocellular carcinoma SMMC7721 cells overexpressing CBX4. XZA-1 can be used for the study of hepatocellular carcinoma .

HY-145291

CPT-Se4	Topoisomerase Apoptosis	Cancer
CPT-Se4, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT-Se4 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se4 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC₅₀= 2.54-6.4 μM) .

HY-145290

CPT-Se3	Topoisomerase Apoptosis	Cancer
CPT-Se3, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT–Se3 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se3 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC₅₀= 2.19-4.7 μM) .

HY-N10877

Chlorajapolide F	Others	Cancer
Chlorajapolide F is a nature product that could be isolated from the aerial part of Chloranthus japonicas. Chlorajapolide F has low cytotoxic activity against NCI-H460 and SMMC-7721 cell lines .

HY-160064

SW1-A aptamer sodium	DNA Alkylator/Crosslinker	Cancer
SW1-A aptamer sodium is an optimized aptamer based on SW1 aptamer (HY-160063) that specifically targets liver cancer SMMC-7721 cells (Kd: 133.73 nM). SW1-A aptamer maintains strong affinity to liver cancer tissues and cells .

HY-N7022R

Eclalbasaponin I (Standard)	Reference Standards Others	Cancer
Eclalbasaponin I (Standard) is the analytical standard of Eclalbasaponin I. This product is intended for research and analytical applications. Eclalbasaponin I is isolated from Eclipta prostrata L with antitumor activity. Eclalbasaponin I inhibits the proliferation of hepatoma cell smmc-7721 with an IC₅₀ value of 111.1703 μg/ml .

HY-160063

SW1 aptamer sodium	Fluorescent Dye DNA Alkylator/Crosslinker	Cancer
SW1 aptamer sodium is a high-affinity DNA aptamer (Kd: 123.62 nM) that targets liver cancer SMMC-7721 cells and targets intracellular components within the nucleus. SW1 aptamer sodium can also identify various other types of cancer cells and tissues, serving as an effective molecular probe for clinical cancer diagnosis .

HY-N10876

8-epi-Chlorajapolide F	Others	Others
8-epi-Chlorajapolide F (compound 1) a sesquiterpene that can be isolated from the aboveground part of the Chloranthus japonicus. 8-epi-Chlorajapolide has few cytotoxic to human cancer cell lines NCI-H460 and SMMC-7721 (IC₅₀s>50 μg/mL) .

HY-N3210

Nb-Demethylechitamine	Others	Cancer
Nb-Demethylechitamine is an alkaloid isolated from the methanol extract of Alstonia rostrata twigs. Nb-Demethylechitamine has in vitro cytotoxic activity against several human cancer cell lines, including human myeloid leukemia HL-60, liver cancer SMMC-7721, lung cancer A-549, breast cancer MCF-7, and colon cancer SW480 cells .

HY-N8508

Myrothecine A	Apoptosis Cytochrome P450 PARP JNK Bcl-2 Family Caspase	Cancer
Myrothecine A is a trichothecene mycotoxin found in M. roridum. Myrothecine A induces apoptosis, promotes the cytochrome c release, PARP-cleavage and phosphorylation of JNK, increases Bax and cleaved caspase-3, -5, and -8 levels. Myrothecine A has anticancer activities and promotes the maturation of DC cells in the microenvironment. Myrothecine A inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells with IC₅₀s of 95, 70, 60, and 25 µM, respectively .

HY-164372

17-Demethoxy-reblastatin 17-DR	HSP Apoptosis	Cancer
17-Demethoxy-reblastatin (17-DR) is an inhibitor for heat shock protein 90 (Hsp90), with an IC₅₀ of 1.82 μM for yeast Hsp90 ATPase. 17-Demethoxy-reblastatin inhibits the proliferation of cancer cell HepG2 and SMMC7721, reduces the colony formation, and induces apoptosis through mitochondria and caspase mediated pathway .

HY-N17005

3-O-(p-Hydroxybenzoyl)serratriol	Others	Cancer
3-O-(p-Hydroxybenzoyl)serratriol is a serratene-type triterpenoid compound with low cytotoxicity against cancer cells (IC₅₀ >100 μg/mL against three human cancer cell lines: K562, SMMC-7721, and SGC7901). 3-O-(p-Hydroxybenzoyl)serratriol can be naturally extracted from the whole plant of Palhinhaea cernua .

HY-N9674

Epimedonin H	Others	Cancer
Epimedonin H is a selective prenylated 2-phenoxychromone compound with no significant cytotoxicity against five human cancer cell lines, including HL-60 and SMMC-7721 (IC₅₀ > 10 μM). Epimedonin H can be used in potential activity screening studies in the field of natural product chemistry. Epimedonin H can be extracted from the dried aerial parts of Epimedium brevicornum (a plant of the genus Epimedium in the Berberidaceae family) .

HY-N15584

Pabularinone Isoheraclenin	Others	Cancer
Pabularinone is a compound found in the plant Clausena lansium. Pabularinone has potent cytotoxic activity, and its activity showed inhibitory effects in human breast cancer (MCF-7) cells (IC₅₀: 33.74 μg/mL). Pabularinone can be used in anti-tumor research .

HY-W106860R

9H-Carbazole-3-carbaldehyde (Standard)	Others Reference Standards	Cancer
9H-Carbazole-3-carbaldehyde (Standard) is the analytical standard of 9H-Carbazole-3-carbaldehyde (HY-W106860). This product is intended for research and analytical applications. 9H-Carbazole-3-carbaldehyde is an anticancer agent that can be isolated from the stems of Lansium parasiticum (Lour.) Skeels. 9H-Carbazole-3-carbaldehyde shows significant cytotoxic activity in a variety of tumor cell lines, especially against H1299 and SMMC-7721 lung cancer cells with IC50 values of 6.19-26.84 μg/mL .

HY-N1268

Scutebata E	Others	Others
Scutebata E is a new neoclerodane diterpenoid isolated from Scutellaria barbata with weak cytotoxic activity .

HY-N1267

Scutebata C	Others	Others
Scutebata C is a neoclerodane diterpenoid isolated from Scutellaria barbata with weak cytotoxic activity .

HY-149063

Antitumor agent-92	Apoptosis	Cancer
Antitumor agent-92, an Icaritin (HY-N0678) derivative, causes arrest at the G0/G1 phase in the cell cycle and induces cell apoptosis. Antitumor agent-92 has the potential for hepatocellular carcinoma (HCC) research .

HY-14664D

Fluvastatin sodium monohydrate XU 62-320 monohydrate	HMG-CoA Reductase (HMGCR) Apoptosis	Cardiovascular Disease Cancer
Fluvastatin (XU 62-320) sodium monohydrate is a first fully synthetic, competitive HMG-CoA reductaseinhibitor with an IC₅₀ of 8 nM. Fluvastatin (sodium monohydrate) protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-143302

Anticancer agent 31	Apoptosis	Cancer
Anticancer agent 31 is a 1,3-diphenylurea quinoxaline derivative, and a anticancer agent. Anticancer agent 31 exhibits antitumor acitvity by arresting cell cycle at S phase and inducing apoptosis .

HY-N17294

Dendromoniliside D	Amylases	Cancer
Dendromoniliside D is a sesquiterpene glycoside. Dendromoniliside D can be isolated from D. nobile. Dendromoniliside D inhibits α-amylase. Dendromoniliside D can be used in the research of liver cancer, lung cancer, and breast cancer .

HY-N15612

5-Hydroxy-7-methoxycoumarin	Others	Cancer
5-Hydroxy-7-methoxycoumarin is a coumarin compound present in the whole plant of Euphorbia kansuensis, with an IC₅₀ > 40 μM against five human cancer cell lines .

HY-N17244

Polysimiaric acid B	Others	Cancer
Polysimiaric acid B is a C₃₁ triterpene found in Polyalthia simiarum and shows no activity against tumor cells .

HY-N18247

12-Ethoxynimbolinin F	Others	Cancer
12-Ethoxynimbolinin F is a nimbolinin-type limonoid found in the fruits of Melia toosendan. 12-Ethoxynimbolinin F shows low cytotoxic activity against cancer cells .

HY-N13833

6''-O-β-D-Apiofuranosylapterin	Drug Derivative	Others
6''-O-β-D-Apiofuranosylapterin is a natural coumarin.

HY-182817

Len-604	EGFR ERK DNA/RNA Synthesis Apoptosis	Cancer
Len-604 is a FGFR inhibitor with IC₅₀ values of 9.71 nM, 9.93 nM, 29.80 nM and 14.48 nM against FGFR4, FGFR1, FGFR2 and FGFR3, respectively. Len-604 reduces the phosphorylation levels of FGFR4 and ERK, and induces DNA damage and apoptosis in cancer cells. Len-604 is applicable to research related to liver cancer .

HY-N7317

Albatrelin G	Drug Derivative	Others
Albatrelin G is a natural phenolic compound.

HY-N18272

1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12β-ethoxynimbolinin	Others	Cancer
1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12β-ethoxynimbolinin is a nimbolinin-type limonoid and cytotoxin, found in the fruits of Melia toosendan. 1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12β-ethoxynimbolinin exhibits in vitro cytotoxicity against human hepatocellular carcinoma, human lung cancer, and human breast cancer cells. 1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12β-ethoxynimbolinin can be used for the research of hepatocellular carcinoma, lung cancer, breast cancer .

HY-N6060A

(Rac)-Ophiopogonanone B	Drug Derivative	Cancer
(Rac)-Ophiopogonanone B is a homoisoflavonoid that can be found in the tubers of Liriope graminifolia (Linn.) Baker. (Rac)-Ophiopogonanone B exhibits cytotoxic activity against Hela cells with an IC₅₀ of 14.0 μg/mL. (Rac)-Ophiopogonanone B can be used in the research of cancer .

HY-D3206

CuFS	Fluorescent Dye	Cancer
CuFS is a reaction-based fluorescent sensor for detecting Cu ²⁺ with zero background fluorescence. CuFS acts as a fluorescence quencher in the absence of Cu ²⁺ and as a fluorescence enhancer in the presence of Cu ²⁺. CuFS can be fabricated into test strips and applied to the detection of Cu ²⁺ in human cancer cells .

HY-N9672

Epimedonin L	Drug Derivative	Others
Epimedonin L is a natural flavonoid.

HY-W420454

Danshenspiroketallactone	Others	Inflammation/Immunology Cancer
Danshenspiroketallactone is a lactone found in the roots of Salvia miltiorrhiza. Danshenspiroketallactone shows no anti-inflammatory and anticancer activity .

HY-D3170

C-HBrO-GGT	Fluorescent Dye γ-Glutamyl Transferase (GGT)	Inflammation/Immunology
C-HBrO-GGT is a sequence-activated two-photon fluorescent probe. C-HBrO-GGT exhibits sequential fluorescence activation properties: it generates fluorescence in response to hypobromous acid only after being hydrolytically activated by γ-glutamyl transpeptidase. C-HBrO-GGT enables verification of the voltage-gated chloride channel (CLC-1)-HBrO-catalase (CAT)-GGT signaling pathway at the cellular level. C-HBrO-GGT can serve as a tool to indicate the precise location of mature atherosclerotic plaques and provide early warning of plaque formation. C-HBrO-GGT is applicable to relevant research on atherosclerosis .

HY-P991883

Metuzumab Licartin; Metuximab; Mehuzumab	Apoptosis CDK Caspase Bcl-2 Family	Cancer
Metuzumab (Licartin) is a human-mouse chimeric IgG1 monoclonal antibody targeting CD147. Metuzumab induces Apoptosis, reduces levels of Cyclin D1, full-length Caspase-3, and Bcl-2, and increases Bax expression. Metuzumab enhances the sensitivity of non-small cell lung cancer (NSCLC) cells to Gemcitabine (HY-17026). Metuzumab is applicable for research on hepatocellular carcinoma and non-small cell lung cancer [1] [2]_.

製品番号	製品名	Type

HY-D3206

CuFS	蛍光色素
CuFS is a reaction-based fluorescent sensor for detecting Cu ²⁺ with zero background fluorescence. CuFS acts as a fluorescence quencher in the absence of Cu ²⁺ and as a fluorescence enhancer in the presence of Cu ²⁺. CuFS can be fabricated into test strips and applied to the detection of Cu ²⁺ in human cancer cells .

HY-D3170

C-HBrO-GGT

蛍光色素

C-HBrO-GGT is a sequence-activated two-photon fluorescent probe. C-HBrO-GGT exhibits sequential fluorescence activation properties: it generates fluorescence in response to hypobromous acid only after being hydrolytically activated by γ-glutamyl transpeptidase. C-HBrO-GGT enables verification of the voltage-gated chloride channel (CLC-1)-HBrO-catalase (CAT)-GGT signaling pathway at the cellular level. C-HBrO-GGT can serve as a tool to indicate the precise location of mature atherosclerotic plaques and provide early warning of plaque formation. C-HBrO-GGT is applicable to relevant research on atherosclerosis .

製品番号	製品名	Target	研究分野

HY-P11308

Cys-GE11	EGFR	Cancer
Cys-GE11 is an N-terminal modified GE11 (HY-P10128) with cysteine (Cys) added. Cys-GE11 can be coupled through the thiol group of Cys. Cys-GE11 can be linked to PEG-P (TMC-DTC) through the N-terminus of cysteine to form a targeted polymer. Cys-GE11 can target cells with high EGFR expression (such as SMMC-7721 cells). Cys-GE11 can significantly enhance drug enrichment at the tumor site and exhibit low toxicity .

製品番号	製品名	Target	研究分野	Image

HY-P991883

Metuzumab Licartin; Metuximab; Mehuzumab	Apoptosis CDK Caspase Bcl-2 Family	Cancer
Metuzumab (Licartin) is a human-mouse chimeric IgG1 monoclonal antibody targeting CD147. Metuzumab induces Apoptosis, reduces levels of Cyclin D1, full-length Caspase-3, and Bcl-2, and increases Bax expression. Metuzumab enhances the sensitivity of non-small cell lung cancer (NSCLC) cells to Gemcitabine (HY-17026). Metuzumab is applicable for research on hepatocellular carcinoma and non-small cell lung cancer [1] [2]_.

製品番号	製品名		Classification

HY-172470

DSPE-PEG2000-GE11		Pegylated Lipids
DSPE-PEG2000-GE11 is a nanocarrier component composed of DSPE and the EGFR-targeting peptide (GE11). DSPE-PEG2000-GE11 specifically binds to EGFR and mediates receptor-mediated endocytosis of micellar drug carriers. DSPE-PEG2000-GE11 can be used for drug delivery .

HY-160064

SW1-A aptamer sodium		Aptamers
SW1-A aptamer sodium is an optimized aptamer based on SW1 aptamer (HY-160063) that specifically targets liver cancer SMMC-7721 cells (Kd: 133.73 nM). SW1-A aptamer maintains strong affinity to liver cancer tissues and cells .

HY-160063

SW1 aptamer sodium		Aptamers
SW1 aptamer sodium is a high-affinity DNA aptamer (Kd: 123.62 nM) that targets liver cancer SMMC-7721 cells and targets intracellular components within the nucleus. SW1 aptamer sodium can also identify various other types of cancer cells and tissues, serving as an effective molecular probe for clinical cancer diagnosis .

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