20-Deoxocarnosol
Based on 1 Customer Validation
20-Deoxocarnosol (compound 7) is a potent anti-cancer agent that can be found in the roots of Salvia deserta. 20-Deoxocarnosol shows cytotoxicity in cancer cells.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 94529-97-2
- Formula: C20H28O3
- Molecular Weight:316.43
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | GI50 |
5.4 μM
Compound: 3
|
Cytotoxicity against human A2780 cells after 48 hrs by SRB assay
Cytotoxicity against human A2780 cells after 48 hrs by SRB assay
|
[PMID: 17190465] |
| HBL-100 | GI50 |
4.6 μM
Compound: 3
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Cytotoxicity against human HBL100 cells after 48 hrs by SRB assay
Cytotoxicity against human HBL100 cells after 48 hrs by SRB assay
|
[PMID: 17190465] |
| SW1573 | GI50 |
22 μM
Compound: 3
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Cytotoxicity against human SW1573 cells after 48 hrs by SRB assay
Cytotoxicity against human SW1573 cells after 48 hrs by SRB assay
|
[PMID: 17190465] |
| T47D | GI50 |
32 μM
Compound: 3
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Cytotoxicity against human T47D cells after 48 hrs by SRB assay
Cytotoxicity against human T47D cells after 48 hrs by SRB assay
|
[PMID: 17190465] |
| WiDr | GI50 |
32 μM
Compound: 3
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Cytotoxicity against human WiDr cells after 48 hrs by SRB assay
Cytotoxicity against human WiDr cells after 48 hrs by SRB assay
|
[PMID: 17190465] |
Deoxocarnosol (compound 7) (0-40 μM) shows cytotoxicity with IC50 values of 40, 32.70, 15.15, 40, 24.79, 40 μM for :A549, SMMC-7721, HL-60, MCF-7, SW480, BEAS-2B cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, SMMC-7721, HL-60, MCF-7, SW480, BEAS-2B cells
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Concentration:0-40 µM
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Incubation Time:
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Result:Showed cytotoxicity with IC50 values of ˃40, 32.70, 15.15, ˃40, 24.79, ˃40 µM for :A549, SMMC-7721, HL-60, MCF-7, SW480, BEAS-2B cells, respectively.
Chemical Information
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CAS No. 94529-97-2
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Appearance Solid
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Molecular Weight 316.43
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Formula C20H28O3
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Color Light yellow to yellow
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SMILES
OC1=C2[C@@](CO3)(CCCC(C)4C)[C@@]4([H])C[C@@]3([H])C2=CC(C(C)C)=C1O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 50 mg/mL (158.01 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1603 mL | 15.8013 mL | 31.6026 mL | 79.0064 mL |
| 5 mM | 0.6321 mL | 3.1603 mL | 6.3205 mL | 15.8013 mL | |
| 10 mM | 0.3160 mL | 1.5801 mL | 3.1603 mL | 7.9006 mL | |
| 15 mM | 0.2107 mL | 1.0534 mL | 2.1068 mL | 5.2671 mL | |
| 20 mM | 0.1580 mL | 0.7901 mL | 1.5801 mL | 3.9503 mL | |
| 25 mM | 0.1264 mL | 0.6321 mL | 1.2641 mL | 3.1603 mL | |
| 30 mM | 0.1053 mL | 0.5267 mL | 1.0534 mL | 2.6335 mL | |
| 40 mM | 0.0790 mL | 0.3950 mL | 0.7901 mL | 1.9752 mL | |
| 50 mM | 0.0632 mL | 0.3160 mL | 0.6321 mL | 1.5801 mL | |
| 60 mM | 0.0527 mL | 0.2634 mL | 0.5267 mL | 1.3168 mL | |
| 80 mM | 0.0395 mL | 0.1975 mL | 0.3950 mL | 0.9876 mL | |
| 100 mM | 0.0316 mL | 0.1580 mL | 0.3160 mL | 0.7901 mL |
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