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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
STP938
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "STP938" in MCE Product Catalog:
1
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Dencatistat (STP938) is a selective and orally active CTPS1 inhibitor (IC50 = 9.3 nM) that reduces the rate-limiting conversion of UTP to CTP. Dencatistat exhibits more than 1300-fold selectivity for CTPS2. Dencatistat modulates BCL2 family transcripts and cell cycle pathways, and inhibits SARS-CoV-2 replication and interferon-induced Mx expression. Dencatistat has antiproliferative and tumor growth-inhibiting effects in mantle cell lymphoma models. Dencatistat inhibits clonogenic growth, migration, invasion, and xenograft tumor growth in lung adenocarcinoma, with tumor selectivity over normal bronchial epithelial cells. Dencatistat can be used for research on COVID-19, mantle cell lymphoma, essential thrombocythemia, and lung adenocarcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
