99 Results for "

Sesquiterpene Lactones

" in MedChemExpress (MCE) Product Catalog:
Products (99)

99 Results for "Sesquiterpene Lactones" in MCE Product Catalog:

42
Parthenolide
Parthenolide
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42 Publications Verification
Cat. No.: HY-N0141
CAS No.: 20554-84-1
Synonyms: (-)-Parthenolide
Category:  

Terpenoids Sesquiterpenes Plants Compositae Euchresta formosana (Hayata) Ohwi Disease Research Fields Cancer

Target:  

NF-κB Autophagy Mitophagy Apoptosis IKK

Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.
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34
Artemisinin
Artemisinin
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34 Cited Publications
Cat. No.: HY-B0094
CAS No.: 63968-64-9
Synonyms: Qinghaosu; NSC 369397
Category:  

Infection Piscidia erythrina L. Neurological Disease Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields

Target:  

HCV Parasite Akt Ferroptosis

Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
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10
Micheliolide
Micheliolide
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10 Cited Publications
Cat. No.: HY-N0847
CAS No.: 68370-47-8
Category:  

Other Monoterpenes other families Terpenoids Other Diseases Plants Disease Research Fields

Target:  

NF-κB PI3K Akt TGF-beta/Smad

Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .
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7
Costunolide
Costunolide
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7 Cited Publications
Cat. No.: HY-N0036
CAS No.: 553-21-9
Synonyms: (+)-Costunolide; Costus lactone
Category:  

Erythrina subumbrans (Hassk.) Merr. Terpenoids Sesquiterpenes Plants Compositae Endogenous metabolite Disease Research Fields Cancer

Target:  

Apoptosis Endogenous Metabolite

Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells .
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6
Helenalin
Helenalin
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6 Cited Publications
Cat. No.: HY-119970
CAS No.: 6754-13-8
Purity:  99.90%
Category:  

other families Terpenoids Sesquiterpenes Plants Disease Research Fields Inflammation/Immunology

Target:  

NF-κB

Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .
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3
Dehydrocostus Lactone
Dehydrocostus Lactone
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3 Cited Publications
Cat. No.: HY-N0591
CAS No.: 477-43-0
Synonyms: (-)-Dehydrocostus lactone; Epiligulyl oxide
Category:  

Saussurea costus (Falc.) Lipsch. Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Cancer

Target:  

Bacterial Apoptosis p38 MAPK NF-κB MAPKAPK2 (MK2) Akt NO Synthase Interleukin Related Caspase

Dehydrocostus Lactone ((-)-Dehydrocostus lactone) is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells .
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3
Linderalactone
Linderalactone
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3 Cited Publications
Cat. No.: HY-N0781
CAS No.: 728-61-0
Category:  

Terpenoids Sesquiterpenes Plants Lauraceae Disease Research Fields Lindera aggregata (Sims) Kosterm. Cancer

Target:  

Apoptosis

Linderalactone is an important sesquiterpene lactone isolated from Lindera aggregata. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 µM .
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2
Helenalin acetate
Helenalin acetate
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2 Cited Publications
Cat. No.: HY-114519
CAS No.: 10180-86-6
Purity:  99.55%
Category:  

Derris robusta Sesquiterpenes Plants Compositae

Target:  

Histone Demethylase NF-κB

Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities .
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2
Arnicolide D
Arnicolide D
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2 Cited Publications
Cat. No.: HY-N6843
CAS No.: 34532-68-8
Category:  

Centipeda minima (L.) A. Braun & Asch. Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Cancer

Target:  

Caspase PI3K Akt mTOR STAT Apoptosis NF-κB Reactive Oxygen Species (ROS)

Arnicolide D is a sesquiterpene lactone that can be isolated from Centipeda minima. Arnicolide D is cytotoxic to tumor cells and can induce cell cycle arrest, apoptosis, and oncosis in tumor cells. Arnicolide D has anti-tumor activity .
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1
Deoxyelephantopin
Deoxyelephantopin
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1 Cited Publications
Cat. No.: HY-N2491
CAS No.: 29307-03-7
Category:  

Terpenoids Sesquiterpenes Amorpha fruticosaL. Plants Compositae Disease Research Fields Cancer

Target:  

NF-κB

Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling .
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1
Methyl 2-furoate
Methyl 2-furoate
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1 Cited Publications
Cat. No.: HY-Y0949
CAS No.: 611-13-2
Synonyms: Methyl furan-2-carboxylate
Category:  

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Methyl 2-furoate (Methyl furan-2-carboxylate) can be used to synthesize cis-fused 5-oxofuro[2,3-b]furans. Methyl 2-furoate is also used in the preparation of sesquiterpene lactones .
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1
Minimolide F
Minimolide F
0 Images
1 Cited Publications
Cat. No.: HY-N8619
CAS No.: 1367351-41-4
Category:  

Centipeda minima (L.) A. Braun & Asch. Terpenoids Sesquiterpenes Plants Compositae

Target:  

Others

Minimolide F is a sesquiterpene lactone. Minimolide F has inhibitory activity against human nasopharyngeal cancer cells. Minimolide F can be used for the research of cancer .
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1
Isodeoxyelephantopin
Isodeoxyelephantopin
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1 Cited Publications
Cat. No.: HY-N2585
CAS No.: 38927-54-7
Category:  

Terpenoids Sesquiterpenes Amorpha fruticosaL. Plants Compositae Disease Research Fields Cancer

Target:  

Reactive Oxygen Species (ROS) NF-κB Autophagy

Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer .
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Lactupicrin
Lactupicrin
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Cat. No.: HY-N8290
CAS No.: 65725-11-3
Synonyms: Lactucopicrin
Category:  

Monophenols Genista quadriflora Munby Terpenoids Sesquiterpenes Phenols Plants Compositae

Target:  

LOX-1 NF-κB Cholinesterase (ChE) Parasite

Lactupicrin (Lactucopicrin) exhibits analgesic, sedative, antimalarial activities and atheroprotective effect. Lactupicrin inhibits acetylcholinesterase (AChE) with an IC50 of 150.3 μM. Lactupicrin is an orally active characteristic bitter sesquiterpene lactone .
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Cynaropicrin
Cynaropicrin
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Cat. No.: HY-N2350
CAS No.: 35730-78-0
Category:  

Saussurea costus (Falc.) Lipsch. Phenols Plants Compositae Disease Research Fields Cancer

Target:  

MMP NF-κB TNF Receptor

Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
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Bigelovin
Bigelovin
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Cat. No.: HY-116506
CAS No.: 3668-14-2
Purity:  99.92%
Category:  

Ketones, Aldehydes, Acids Acacia auriculiformis A.Cunn. ex Benth Plants Compositae Disease Research Fields Cancer

Target:  

RAR/RXR Reactive Oxygen Species (ROS) Apoptosis Autophagy

Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .
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Artemisinin (Standard)
Artemisinin (Standard)
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Cat. No.: HY-B0094R
CAS No.: 63968-64-9
Synonyms: Qinghaosu (Standard); NSC 369397 (Standard)
Category:  

Piscidia erythrina L. Terpenoids Sesquiterpenes Plants Compositae

Target:  

Reference Standards HCV Parasite Akt Ferroptosis

Artemisinin (Standard) is the analytical standard of Artemisinin. This product is intended for research and analytical applications. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
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Granilin
Granilin
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Cat. No.: HY-N9357
CAS No.: 40737-97-1
Category:  

Infection Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Erythrina arborescens Roxb.

Target:  

Bacterial Fungal

Granilin, a sesquiterpene lactone, can be found in the flower buds of Carpesium triste. Granilin can be used as the bactericide and fungicide .
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Linderane
Linderane
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Cat. No.: HY-N0688
CAS No.: 13476-25-0
Category:  

Terpenoids Sesquiterpenes Plants Lauraceae Disease Research Fields Inflammation/Immunology Lindera aggregata (Sims) Kosterm.

Target:  

ERK STAT Phosphodiesterase (PDE) PKA p38 MAPK Keap1-Nrf2 JAK Interleukin Related Apoptosis Cannabinoid Receptor

Linderane is an orally active natural sesquiterpene lactone with blood-brain barrier permeability. Linderane indirectly activates PDE3 by activating ERK/STAT3, thereby inhibiting the cAMP/PKA/CREB signaling pathway and hepatic gluconeogenesis. Linderane protects pancreatic β cells against oxidative damage by inhibiting the activation of the p38 MAPK pathway and activating the Nrf2 pathway. Linderane inhibits cell apoptosis and ameliorates intestinal mucosal inflammation by suppressing the IL-6/JAK/STAT3 signaling pathway. Linderane reduces pain sensitivity and alleviates anxiety-like behaviors by activating cannabinoid receptor 2 (CB2R). Linderane can be used in studies related to type 2 diabetes, ulcerative colitis, and chronic inflammatory pain with anxiety .
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Cnicin
Cnicin
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Cat. No.: HY-137984
CAS No.: 24394-09-0
Purity:  99.88%
Category:  

Terpenoids Sesquiterpenes Plants Compositae Mariosousa willardiana (Rose) Seigler & Ebinger

Target:  

SARS-CoV Apoptosis

Cnicin is an orally bioavailable sesquiterpene lactone. Cnicin has antibacterial and antiproliferative properties and induces apoptosis in primary myeloma cells. Cnicin also exhibits activity against SARS-CoV-2. Cnicin inhibits the viral replication of SARS CoV-2 with an IC50 of 1.18 μg/mL. Cnicin can promote functional nerve regeneration .
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