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TG02

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15163
    Zotiraciclib
    2 Publications Verification

    TG02; SB1317

    JAK CDK FLT3 Cancer
    Zotiraciclib (TG02; SB1317) is an orally active JAK2/FLT3/CDK2 inhibitor with IC50 values of 13 nM, 73 nM and 56 nM , respectively. Zotiraciclib inhibits cancer cell proliferation, tumor growth and the activity of CYP2D6. Zotiraciclib exhibits high plasma protein binding rate, Caco-2 permeability and tissue distribution capacity, as well as metabolic stability in human and canine liver microsomes. Zotiraciclib achieves tumor growth inhibition in nude mouse models of colon cancer and lymphoma xenografts. Zotiraciclib can be used for research related to colon cancer, B-cell lymphoma, advanced leukemia, acute leukemia and multiple myeloma .
    Zotiraciclib
  • HY-15166
    (E/Z)-Zotiraciclib
    Maximum Cited Publications
    6 Publications Verification

    (E/Z)-TG02; (E/Z)-SB1317

    CDK JAK FLT3 Cancer
    (E/Z)-Zotiraciclib ((E/Z)-TG02) is a potent inhibitor of CDK2, JAK2 and FLT3 with IC50s of 13, 73 and 56 nM, respectively. (E/Z)-Zotiraciclib effectively inhibits the proliferation of cancer cells, it can be used for the research of cancer .
    (E/Z)-Zotiraciclib
  • HY-15166A
    (E/Z)-Zotiraciclib hydrochloride
    Maximum Cited Publications
    6 Publications Verification

    (E/Z)-TG02 hydrochloride; (E/Z)-SB1317 hydrochloride

    CDK JAK FLT3 Cancer
    (E/Z)-Zotiraciclib ((E/Z)-TG02) is an orally active inhibitor of CDK2, JAK2 and FLT3 with IC50s of 13, 73 and 56 nM, respectively. (E/Z)-Zotiraciclib effectively inhibits the proliferation of cancer cells, it can be used for the research of cancer .
    (E/Z)-Zotiraciclib hydrochloride
  • HY-15166B
    (E/Z)-Zotiraciclib citrate
    Maximum Cited Publications
    6 Publications Verification

    (E/Z)-TG02 citrate; (E/Z)-SB1317 citrate

    CDK JAK FLT3 Cancer
    (E/Z)-Zotiraciclib citrate is a potent CDK2, JAK2, and FLT3 inhibitor .
    (E/Z)-Zotiraciclib citrate

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