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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
TGF-β receptor-1
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "TGF-β receptor-1" in MCE Product Catalog:
Cat. No.: HY-160237
CAS No.: 2426547-83-1
Target:
Research Areas:
HYL001 (compund 338) is a potent inhibitor of TGFβ receptor 1 (ALK5) that is approximately 9 times more potent than the structurally related compound Galunisertib (HY-13226) and is able to eliminate liver metastases established in mice .
Cat. No.: HY-105067A
CAS No.: 922174-60-5
Synonyms: GV-1001 hydrochloride
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Tertomotide hydrochloride (GV-1001 hydrochloride) is a 16-amino acid peptide derived from hTERT, with both cell-penetrating and immunostimulatory activities, and it can cross the blood-brain barrier. Tertomotide hydrochloride binds to STING, HO-1, eHSP70, eHSP90, bradykinin receptor 1, VEGFR-2, NF-κB, p38 MAPK and Smad2. Tertomotide hydrochloride induces type I interferon production, mitochondrial DNA stress and T-cell responses; inhibits HBV replication, angiogenesis, TGF-β signaling pathway, NF-κB activation, endothelial-mesenchymal transition (EndMT) and fibrosis; regulates microglia; and exerts neuroprotective, anti-inflammatory, antioxidant, anti-apoptotic and anti-tumor effects. Tertomotide hydrochloride can be used in research related to hepatitis B virus infection, Alzheimer's disease, non-small cell lung cancer, atherosclerosis and depression .
Cat. No.: HY-174531
Human TGFBR1 mRNA encodes the human transforming growth factor beta receptor 1 (TGFBR1) protein, a serine/threonine protein kinase. TGFBR1 can form a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm.
Cat. No.: HY-P72453
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase receptor R4; Prev. ESS1; Activin receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta receptor Type-1; TGF-Beta Type I receptor; ACVRLK4; TGF-Beta receptor Type I; TBR-I; LDS1A; TBRI; LDS2A; Activin A receptor Type II-Like Protein Kinase Of 53kD; AAT5; Mutant Transforming Growth Factor Beta receptor I; LDS1; Activin A receptor Type II-Like Kinase, 53kDa; Transforming Growth Factor Beta receptor 1; Transforming Growth Factor Beta receptor I
Species:
Human
Source:
HEK293
Cat. No.: HY-P706225
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein Kinase receptor R4; Prev. ESS1; Activin receptor-Like Kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta receptor Type-1; TGF-Beta Type I receptor; ACVRLK4; TGF-Beta receptor Type I; TBR-I; LDS1A; TBRI; LDS2A; Activin A receptor Type II-Like Protein Kinase Of 53kD; AAT5; Mutant Transforming Growth Factor Beta receptor I; LDS1; Activin A receptor Type II-Like Kinase, 53kDa; Transforming Growth Factor Beta receptor 1; Transforming Growth Factor Beta receptor I
Species:
Human
Source:
E. coli
Cat. No.: HY-P70384
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GFRA1; GDNFR-Alpha-1; Prev. GDNFRA; Glial Cell Line-Derived Neurotrophic Factor receptor Alpha; RETL1; PI-Linked Cell-Surface Accessory Protein; TRNR1; GPI-Linked Anchor Protein; GDNF Family receptor Alpha-1; Alternative Protein GFRA1; GFR-ALPHA-1; GDNF receptor Alpha 1d; GDNFR; GDNF receptor Alpha 1e; RET1L; GFR-Alpha-1; TGF-Beta-Related Neurotrophic Factor receptor 1; GFRalpha-1; GDNF receptor Alpha-1; RHDA4; GDNF Family receptor Alpha 1; RET Ligand 1
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
