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2 Results for "
TL13-112
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "TL13-112" in MCE Product Catalog:
2
2 Cited Publications
Research Areas:
TL13-112 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC50 value of 0.14 nM. TL13-112 also prompts the degradation of additional kinases including Aurora A, FER, PTK2 and RPS6KA1 with IC50 values of 8550 nM, 42.4 nM, 25.4 nM, and 677 nM, respectively. TL13-112 is comprised of the conjugation of Ceritinib (HY-15656) and the Cereblon ligand of Pomalidomide (HY-10984) .
Cat. No.: HY-136195
CAS No.: 2229037-09-4
Target:
Research Areas:
TL13-110 is a negative control for TL13-112 (HY-123919) and a potent ALK inhibitor with an IC50 of 0.34 nM. TL13-110 does not degrade ALK in cells .
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