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Results for "

UGT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	UGT (18) Apoptosis (4) Autophagy (7) Bacterial (5) Bcl-2 Family (1) Biochemical Assay Reagents (2) Calcium Channel (1) Carboxylesterase (CES) (2) Cholinesterase (ChE) (2) COX (2) Cytochrome P450 (5) Dopamine Receptor (1) Drug Derivative (1) Drug Metabolite (9) Endogenous Metabolite (6) Environmental Pollutants (2) Estrogen Receptor/ERR (5) Fc Receptor (FcR) (1) Fluorescent Dye (3) Fungal (2) GABA Receptor (1) Glutathione S-transferase (2) Glycosidase (2) HBV (1) HIV (3) HIV Integrase (3) Influenza Virus (1) Interleukin Related (2) Isotope-Labeled Compounds (5) Keap1-Nrf2 (3) Leukotriene Receptor (1) Methionine Adenosyltransferase (MAT) (2) mTOR (1) NF-κB (2) NO Synthase (2) OAT (3) P2X Receptor (1) p38 MAPK (5) PGE synthase (1) Platelet-activating Factor Receptor (PAFR) (1) PPAR (1) Pregnane X Receptor (PXR) (1) RANKL/RANK (1) RAR/RXR (1) Reactive Oxygen Species (ROS) (2) Reference Standards (10) Sirtuin (2) Small Interfering RNA (siRNA) (28) SOD (3) Tau Protein (2) TNF Receptor (1)
By Research Areas:	Cancer (15) Cardiovascular Disease (6) Endocrinology (5) Infection (17) Inflammation/Immunology (10) Metabolic Disease (17) Neurological Disease (12)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (5) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (20) siRNAs (28)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: UGT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0372

Licochalcone A 15+ Cited Publications	Autophagy	Cancer
Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and K_i values lower than 5 μM) .

HY-N0168

Hesperetin Maximum Cited Publications 25 Publications Verification	p38 MAPK Autophagy Apoptosis Reactive Oxygen Species (ROS) NF-κB Bcl-2 Family	Neurological Disease Cancer
Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce Bcl-2 and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor .

HY-111832

1,2,3,6-Tetragalloylglucose TeGG	UGT	Infection Metabolic Disease
1,2,3,6-Tetragalloylglucose (TEgG) is a competitive inhibitor of UDP-glucuronyltransferase *UGT1A1, targeting the competitive substrate binding site of UGT1A1. 1,2,3,6-Tetragalloylglucose inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC₅₀* of 6.01 μM and 4.31 μM, respectively, and binds to UGT1A1 with K_i of 3.55 μM. 1,2,3,6-Tetragalloylglucose also induces tumor cell apoptosis, inhibit cell proliferation, activates caspase-3 and induces DNA fragmentation in HL-60 cells. 1,2,3,6-Tetragalloylglucose also inhibits HIV integrase and reverse transcriptase, and inhibits HCV protease .

HY-15592

Cabotegravir 10+ Cited Publications GSK-1265744; S/GSK1265744	OAT HIV HIV Integrase	Infection
Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC₅₀ values of 2.5 nM, 0.41 μM and 0.81 μM for HIV_ADA, OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS .

HY-Y1683

DL-Menthol Racementhol	Environmental Pollutants GABA Receptor	Infection Neurological Disease
DL-Menthol (Racementhol) is an orally active, GABA_aR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABA_AR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production .

HY-N0548

α-Angelica lactone 2 Publications Verification	Glutathione S-transferase	Cancer
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and *UDP-glucononosyltransferase (UGT) detoxification enzymes* .

HY-107850

Pregnanediol NSC 1612; NSC 47462	Drug Metabolite UGT	Cardiovascular Disease Metabolic Disease
Pregnanediol (NSC 1612) is a Progesterone (HY-N0437) metabolite. Pregnanediol does not affect the transcriptional activity of UGT1A1 enhancer-promoter complex of WT and variant type. pregnanediol inhibits glucuronidation activity of *G71R-UGT1A1*. Pregnanediol is a cause of breast milk jaundice in carriers of G71R .

HY-N2574

Gitogenin 2 Publications Verification	Glycosidase	Metabolic Disease
Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC₅₀ values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms .

HY-N0235

Bakuchiol 2 Publications Verification (S)-(+)-Bakuchiol	Carboxylesterase (CES) p38 MAPK Autophagy UGT	Infection Metabolic Disease Inflammation/Immunology Cancer
Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC₅₀s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory , antibacterial , antitumor therapies, as well as drug metabolism regulation.

HY-137083

Trifluoperazine N-Glucuronide UGT1A4	UGT	Metabolic Disease
Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation .

HY-137522

Zidovudine O-β-D-glucuronide sodium 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium	Drug Metabolite	Others
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect *UGT2B7* activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

HY-131703

UGT8-IN-1 1 Publications Verification	UGT	Metabolic Disease
UGT8-IN-1 is a brain penetrable and orally active inhibitor of ceramide galactosyltransferase enzyme (UGT8). UGT8-IN-1 can be used in the study for lysosomal storage disorders .

HY-N0762

Isobavachin 5 Publications Verification	Cytochrome P450 UGT p38 MAPK NF-κB NO Synthase COX Fc Receptor (FcR) RANKL/RANK Keap1-Nrf2 Reactive Oxygen Species (ROS) Apoptosis Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia. Isobavachin inhibits human CYP2B6, CYP2C9, CYP2C19, *UGT1A1, UGT1A9, and UGT2B7. Isobavachin suppresses MAPK* activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2, FcεRI-mediated signaling pathways, and RANKL-induced osteoclastogenesis. Isobavachin induces autophagy, cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis, iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer, prostate cancer, glioma, periodontitis-induced bone loss, and Alzheimer's disease .

HY-N0859

Schisanhenol Schizanhenol; Gomisin-K3	UGT Cholinesterase (ChE) Tau Protein SOD Sirtuin	Neurological Disease Inflammation/Immunology Cancer
Schisanhenol (Schizanhenol), a lignan, is an orally active antioxidant. Schisanhenol reduces AChE activity, increases SIRT1 and PGC-1α expression, and decreases phosphorylated Tau (Ser 396) levels. Schisanhenol increases SOD and glutathione peroxidase activity, decreases malondialdehyde (MDA) content, and inhibits *UGT2B7* activitY. Schisanhenol attenuates ox-LDL-induced apoptosis, intracellular reactive oxygen species generation, and cytotoxicity in endothelial cells. Schisanhenol inhibits LDL oxidation, brain mitochondrial and membrane peroxidative damage, and brain mitochondrial swelling and disintegration. Schisanhenol can be used for the research of Alzheimer’s disease, atherosclerosis, brain ischemia, and age-related brain deterioration .

HY-119323

7-Azido-4-methylcoumarin 1 Publications Verification	Fluorescent Dye	Others
7-Azido-4-methylcoumarin is a selective coumarin-based fluorescent probe for hydrogen sulfide (H₂S). In the presence of H₂S, the aromatic azido group of 7-Azido-4-methylcoumarin is selectively reduced to produce the fluorescently active 7-amino-4-methylcoumarin (AMC). 7-Azido-4-methylcoumarin binds to the coumarin/phenol-binding site of BSA, the aglycone-binding site of *UGT1A6, and the substrate-binding site of SULT1A1*, respectively. 7-Azido-4-methylcoumarin retains its fluorescent properties after covalent binding, acts as a fluorescent H₂S probe, and does not react with cysteine, homocysteine or glutathione (Ex/Em = 340/445 nm) .

HY-125904

4-Hydroxyretinoic acid 1 Publications Verification	RAR/RXR UGT Cytochrome P450 Apoptosis Drug Derivative	Neurological Disease Inflammation/Immunology Cancer
4-Hydroxyretinoic acid (4-HRA) is a derivative of Retinoic acid (HY-14649). 4-Hydroxyretinoic acid is formed via the catalysis of retinol by cytochrome P-450 isoenzymes. 4-Hydroxyretinoic acid also serves as a substrate for UDP-glucuronosyltransferase (s) and recombinant *UGT2B7. 4-Hydroxyretinoic acid binds to the nuclear receptor RAR* (Retinoic Acid Receptor), activates RAR and RXR-alpha, subsequently regulates gene expression and cell differentiation, and induces cancer cell apoptosis (Apoptosis). 4-Hydroxyretinoic acid also participates in multiple physiological processes such as immunoregulation, neuroprotection and antioxidation .

HY-160250

UGT1A1-IN-1	Fluorescent Dye UGT	Metabolic Disease
UGT1A1-IN-1 is a *UGT1A1* inhibitor and fluorescent probe (Ex=370 nm, Em=520 nm), with an IC₅₀ of 1.33 μM and a K_i of 5.02 μM. UGT1A1-IN-1 is selectively glucuronidated by UGT1A1 at the bilirubin homologous binding site, and its PET effect is blocked along with this reaction, triggering fluorescence changes. UGT1A1-IN-1 can serve as a substitute for bilirubin to detect UGT1A1 activity and perform high-throughput screening of UGT1A1 modulators .

HY-135582

Raloxifene 4'-glucuronide	Estrogen Receptor/ERR	Endocrinology
Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-N4194

Glabrone 1 Publications Verification	PPAR Influenza Virus	Infection Metabolic Disease
Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity .

HY-15592A

Cabotegravir sodium 10+ Cited Publications GSK-1265744 sodium; S/GSK1265744 sodium	OAT HIV HIV Integrase	Infection
Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC₅₀ values of 2.5 nM, 0.41 μM and 0.81 μM for HIV_ADA, OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS .

HY-176515

Cipepofol glucuronide Ciprofol Glucuronide	Drug Metabolite	Neurological Disease
Cipepofol glucuronide (Ciprofol Glucuronide) (M4) is a glucuronide metabolite of Ciprofol (HY-116152). Cipepofol glucuronide has no significant inhibitory activity toward P450s and UDP-glucuronosyltransferases (UGTs), and it has a lower risk of acting as a perpetrator for drug-drug interactions (DDIs). Cipepofol glucuronide can be used for anesthesia research .

HY-17518

Valifenalate IR5885; Valiphenal	Environmental Pollutants Bacterial Fungal	Infection
Valifenalate (IR5885; Valiphenal) is an insecticide agent and fungicide, which is approved for application on high-value crops such as grapes, tomatoes and other vegetables. Valifenalate interferes with cell-wall synthesisValifenalate is effective against various types of mildew. Valifenalate can be used against crown rot of rose cuased by Phytophthora citrophthora. Valifenalate induces non-adverse thyroid changes via adaptive induction of uridine 5’-diphosphoglucuronosyltransferase (UGT) in the liver of dogs and rats .

HY-N4267

Yangambin	Calcium Channel Platelet-activating Factor Receptor (PAFR) UGT Leukotriene Receptor TNF Receptor PGE synthase Interleukin Related	Cardiovascular Disease Infection Inflammation/Immunology
Yangambin is a PAF receptor antagonist and *UGT1A1/UGT1A3* inhibitor, with an IC₅₀ of 29.7 μM and a K_i of 17.1 μM against human *UGT1A1, and an IC₅₀* of 56.5 μM and a K_i of 66.8 μM against human *UGT1A3. Yangambin blocks PAF-mediated responses, inhibits LTB₄-mediated neutrophil infiltration, and suppresses inflammatory events and anaphylactic contraction. Yangambin acts as a central nervous system inhibitor to reduce spontaneous activity, and also exhibits analgesic, anticonvulsant, antileishmanial, vasodilatory and hypotensive effects. Yangambin blocks voltage-gated Ca ²⁺* channels, reduces the production of NO, TNF-α, IL-6 and PGE2 in cells, increases the production of IL-10, and exerts a protective effect against cardiovascular injury. Yangambin can be used in research related to allergies, cutaneous leishmaniasis, central nervous system diseases and cardiovascular diseases .

HY-130046

16-Epiestriol 16-epi-Estriol; 16β,17β-Estriol	UGT Bacterial	Infection Inflammation/Immunology
16-Epiestriol (16-epi-Estriol; 16β,17β-Estriol) is a natural stereoisomer of estriol and an anti-inflammatory agent that targets *UGT. The Ki values of 16-Epiestriol against human UGT1A10* and *UGT2B7* are 98.1 μM and 162 μM, respectively. As a glucuronidation substrate, 16-Epiestriol can be modified at the 3-OH, 16-OH and 17-OH sites by various *UGT* enzymes; in liver microsomes, the modification mainly occurs at the 16-OH and 17-OH sites, while reactions take place at all three sites in intestinal microsomes. 16-Epiestriol acts on the phase II inflammatory process by blocking edema mediated by prostaglandins and leukocyte infiltration. It lacks glycogenic activity or any effect on blood glucose levels, and serves as an important candidate molecule in the research of inflammatory diseases .

HY-N1902R

4-Hydroxyphenylacetic acid (Standard)	Reference Standards Keap1-Nrf2 Endogenous Metabolite	Metabolic Disease
4-Hydroxyphenylacetic acid (Standard) is the analytical standard of 4-Hydroxyphenylacetic acid. This product is intended for research and analytical applications. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 . IC₅₀ & Target:Nrf2 In Vivo: 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1 .

HY-137083S

Trifluoperazine N-glucuronide-d3 UGT1A4-d₃	Isotope-Labeled Compounds	Metabolic Disease
Trifluoperazine N-glucuronide-d₃ is deuterium labeled Trifluoperazine N-Glucuronide. Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation .

HY-N0548R

α-Angelica lactone (Standard)	Glutathione S-transferase Reference Standards	Cancer
α-Angelica lactone (Standard) is the analytical standard of α-Angelica lactone. This product is intended for research and analytical applications. α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

HY-100319

UK-157147	UGT	Metabolic Disease
UK-157147 is a substrate for UDP-glucuronosyltransferases (UGT1A1) with a K_m value of 105 μM.

HY-113216R

Asymmetric dimethylarginine (Standard) NG,NG-Dimethylarginine (Standard)	Reference Standards Endogenous Metabolite NO Synthase	Cardiovascular Disease Cancer
Hesperetin (Standard) is the analytical standard of Hesperetin. This product is intended for research and analytical applications. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis.

HY-N13388

5-Hydroxytryptophol-O-glucuronide UGT1A6	Biochemical Assay Reagents	Others
5-Hydroxytryptophol-O-glucuronide is an authentic glucuronide standard and probe metabolite. 5-Hydroxytryptophol-O-glucuronide is used to detect the activity of human *UGT1A6* in in vitro systems including human liver microsomes and recombinant *UGT1A6* .

HY-RS16380

UGT1A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A Human Pre-designed siRNA Set A UGT1A Human Pre-designed siRNA Set A

HY-W278777

Monohexyl phthalate	Biochemical Assay Reagents	Others
Monohexyl phthalate is a competitive inhibitor towards *UGT1A9, with an IC₅₀* of 12.46 μM and a K_i of 7.47 μM .

HY-N0372R

Licochalcone A (Standard)	Reference Standards Autophagy	Cancer
Licochalcone A (Standard) is the analytical standard of Licochalcone A. This product is intended for research and analytical applications. Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and Ki values lower than 5 μM) .

HY-172338

Chlorzoxazone-N-glucuronide CHZ-N-Glc	Endogenous Metabolite	Others
Chlorzoxazone-N-glucuronide is a phase II metabolite of the skeletal muscle relaxant – Chlorzoxazone. Chlorzoxazone-N-glucuronide can be synthesized via glucuronidation of chlorozoxazone by UGT1A9 .

HY-N0168S

Hesperetin-d3	p38 MAPK Apoptosis Autophagy	Neurological Disease
Hesperetin-d₃ is the deuterium labeled Hesperetin . Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis .

HY-172565

Posaconazole D-glucuronide SCH 56592 D-glucuronide	Drug Metabolite UGT	Infection
Posaconazole D-glucuronide (SCH 56592 D-glucuronide) is a glucuronide metabolite of the antifungal agent Posaconazole (HY-17373). Posaconazole D-glucuronide can be formed in human liver microsomes catalyzed by *UGT1A4* .

HY-N0235R

Bakuchiol (Standard) (S)-(+)-Bakuchiol (Standard)	Carboxylesterase (CES) Reference Standards p38 MAPK Autophagy UGT	Infection Metabolic Disease Inflammation/Immunology Cancer
Bakuchiol (Standard) is the analytical standard of Bakuchiol. This product is intended for research and analytical applications. Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC₅₀s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory , antibacterial , antitumor therapies, as well as drug metabolism regulation.

HY-15592R

Cabotegravir (Standard) GSK-1265744 (Standard); S/GSK1265744 (Standard)	OAT Reference Standards HIV HIV Integrase	Infection
Cabotegravir (Standard) is the analytical standard of Cabotegravir. This product is intended for research and analytical applications. Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC₅₀ values of 2.5 nM, 0.41 μM and 0.81 μM for HIV_ADA, OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS .

HY-137522S

Zidovudine O-β-D-glucuronide-d3 sodium 3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 sodium	Isotope-Labeled Compounds Drug Metabolite	Others
Zidovudine O-β-D-glucuronide-d₃ sodium (3'-Azido-3'-deoxythymidine β-D-glucuronide-d₃ sodium) is a deuterium labeled Zidovudine O-β-D-glucuronide sodium (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect *UGT2B7* activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

HY-137083A

Trifluoperazine N-glucuronide chloride UGT1A4 chloride	Drug Metabolite	Neurological Disease
Trifluoperazine N-glucuronide (UGT1A4) chloride is a metabolite of the antipsychotic agent trifluoperazine. Trifluoperazine N-glucuronide (UGT1A4) chloridecatalyzes the imipramine and trifluoperazine Nglucuronide formation .

HY-RS15443

UGT8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT8 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT8 Human Pre-designed siRNA Set A UGT8 Human Pre-designed siRNA Set A

HY-RS27017

Ugt1a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ugt1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Ugt1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ugt1a Rat Pre-designed siRNA Set A Ugt1a Rat Pre-designed siRNA Set A

HY-RS15436

UGT2A3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT2A3 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT2A3 Human Pre-designed siRNA Set A UGT2A3 Human Pre-designed siRNA Set A

HY-RS15433

UGT1A9 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A9 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A9 Human Pre-designed siRNA Set A UGT1A9 Human Pre-designed siRNA Set A

HY-RS15430

UGT1A6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A6 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A6 Human Pre-designed siRNA Set A UGT1A6 Human Pre-designed siRNA Set A

HY-RS15427

UGT1A10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A10 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A10 Human Pre-designed siRNA Set A UGT1A10 Human Pre-designed siRNA Set A

HY-RS15434

UGT2A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT2A1 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT2A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT2A1 Human Pre-designed siRNA Set A UGT2A1 Human Pre-designed siRNA Set A

HY-RS15428

UGT1A3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A3 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A3 Human Pre-designed siRNA Set A UGT1A3 Human Pre-designed siRNA Set A

HY-RS15429

UGT1A4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A4 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A4 Human Pre-designed siRNA Set A UGT1A4 Human Pre-designed siRNA Set A

HY-RS28491

Ugt1a4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ugt1a4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ugt1a4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ugt1a4 Rat Pre-designed siRNA Set A Ugt1a4 Rat Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0372

Licochalcone A 15+ Cited Publications	Chalcones Flavonoids Classification of Application Fields Leguminosae Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification Cancer	Autophagy
Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and K_i values lower than 5 μM) .

HY-N0168

Hesperetin Maximum Cited Publications 25 Publications Verification	Structural Classification Flavonoids other families Neurological Disease Classification of Application Fields Sunscreen Flavonones Cosmetic Research Plants Disease Research Fields Source Classification Cancer	p38 MAPK Autophagy Apoptosis Reactive Oxygen Species (ROS) NF-κB Bcl-2 Family
Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce Bcl-2 and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor .

HY-111832

1,2,3,6-Tetragalloylglucose TeGG	other families Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	UGT
1,2,3,6-Tetragalloylglucose (TEgG) is a competitive inhibitor of UDP-glucuronyltransferase *UGT1A1, targeting the competitive substrate binding site of UGT1A1. 1,2,3,6-Tetragalloylglucose inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC₅₀* of 6.01 μM and 4.31 μM, respectively, and binds to UGT1A1 with K_i of 3.55 μM. 1,2,3,6-Tetragalloylglucose also induces tumor cell apoptosis, inhibit cell proliferation, activates caspase-3 and induces DNA fragmentation in HL-60 cells. 1,2,3,6-Tetragalloylglucose also inhibits HIV integrase and reverse transcriptase, and inhibits HCV protease .

HY-Y1683

DL-Menthol Racementhol	Structural Classification Natural Products Classification of Application Fields Leguminosae Labiatae Other Diseases Erythrina poeppigiana Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification	Environmental Pollutants GABA Receptor
DL-Menthol (Racementhol) is an orally active, GABA_aR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABA_AR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production .

HY-N0548

α-Angelica lactone 2 Publications Verification	Natural Products Classification of Application Fields Dicerothamnus rhinocerotis Umbelliferae Plants Disease Research Fields Source Classification Cancer	Glutathione S-transferase
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and *UDP-glucononosyltransferase (UGT) detoxification enzymes* .

HY-107850

Pregnanediol NSC 1612; NSC 47462	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Drug Metabolite UGT
Pregnanediol (NSC 1612) is a Progesterone (HY-N0437) metabolite. Pregnanediol does not affect the transcriptional activity of UGT1A1 enhancer-promoter complex of WT and variant type. pregnanediol inhibits glucuronidation activity of *G71R-UGT1A1*. Pregnanediol is a cause of breast milk jaundice in carriers of G71R .

HY-N2574

Gitogenin 2 Publications Verification	Tribulus terrester Linn. Classification of Application Fields Zygophyllaceae Metabolic Disease Plants Disease Research Fields Steroids Source Classification	Glycosidase
Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC₅₀ values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms .

HY-N0235

Bakuchiol 2 Publications Verification (S)-(+)-Bakuchiol	Monophenols Classification of Application Fields Leguminosae Phenols Psoralea corylifolia L. Plants Disease Research Fields Source Classification Cancer	Carboxylesterase (CES) p38 MAPK Autophagy UGT
Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC₅₀s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory , antibacterial , antitumor therapies, as well as drug metabolism regulation.

HY-N0762

Isobavachin 5 Publications Verification	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Source Classification	Cytochrome P450 UGT p38 MAPK NF-κB NO Synthase COX Fc Receptor (FcR) RANKL/RANK Keap1-Nrf2 Reactive Oxygen Species (ROS) Apoptosis Autophagy
Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia. Isobavachin inhibits human CYP2B6, CYP2C9, CYP2C19, *UGT1A1, UGT1A9, and UGT2B7. Isobavachin suppresses MAPK* activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2, FcεRI-mediated signaling pathways, and RANKL-induced osteoclastogenesis. Isobavachin induces autophagy, cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis, iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer, prostate cancer, glioma, periodontitis-induced bone loss, and Alzheimer's disease .

HY-N0859

Schisanhenol Schizanhenol; Gomisin-K3	Structural Classification Monophenols Classification of Application Fields Lignans Phenols Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Source Classification Cancer	UGT Cholinesterase (ChE) Tau Protein SOD Sirtuin
Schisanhenol (Schizanhenol), a lignan, is an orally active antioxidant. Schisanhenol reduces AChE activity, increases SIRT1 and PGC-1α expression, and decreases phosphorylated Tau (Ser 396) levels. Schisanhenol increases SOD and glutathione peroxidase activity, decreases malondialdehyde (MDA) content, and inhibits *UGT2B7* activitY. Schisanhenol attenuates ox-LDL-induced apoptosis, intracellular reactive oxygen species generation, and cytotoxicity in endothelial cells. Schisanhenol inhibits LDL oxidation, brain mitochondrial and membrane peroxidative damage, and brain mitochondrial swelling and disintegration. Schisanhenol can be used for the research of Alzheimer’s disease, atherosclerosis, brain ischemia, and age-related brain deterioration .

HY-N4194

Glabrone 1 Publications Verification	Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones Source Classification	PPAR Influenza Virus
Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity .

HY-N4267

Yangambin	Cardiovascular Disease Structural Classification other families Classification of Application Fields Lignans Phenylpropanoids Plants Disease Research Fields Source Classification	Calcium Channel Platelet-activating Factor Receptor (PAFR) UGT Leukotriene Receptor TNF Receptor PGE synthase Interleukin Related
Yangambin is a PAF receptor antagonist and *UGT1A1/UGT1A3* inhibitor, with an IC₅₀ of 29.7 μM and a K_i of 17.1 μM against human *UGT1A1, and an IC₅₀* of 56.5 μM and a K_i of 66.8 μM against human *UGT1A3. Yangambin blocks PAF-mediated responses, inhibits LTB₄-mediated neutrophil infiltration, and suppresses inflammatory events and anaphylactic contraction. Yangambin acts as a central nervous system inhibitor to reduce spontaneous activity, and also exhibits analgesic, anticonvulsant, antileishmanial, vasodilatory and hypotensive effects. Yangambin blocks voltage-gated Ca ²⁺* channels, reduces the production of NO, TNF-α, IL-6 and PGE2 in cells, increases the production of IL-10, and exerts a protective effect against cardiovascular injury. Yangambin can be used in research related to allergies, cutaneous leishmaniasis, central nervous system diseases and cardiovascular diseases .

HY-N1902R

4-Hydroxyphenylacetic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Monophenols Phenols Plants Compositae Endogenous metabolite Erythrina latissima E. Mey. Source Classification	Reference Standards Keap1-Nrf2 Endogenous Metabolite
4-Hydroxyphenylacetic acid (Standard) is the analytical standard of 4-Hydroxyphenylacetic acid. This product is intended for research and analytical applications. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 . IC₅₀ & Target:Nrf2 In Vivo: 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1 .

HY-N0548R

α-Angelica lactone (Standard)	Structural Classification Natural Products Dicerothamnus rhinocerotis Umbelliferae Plants Source Classification	Glutathione S-transferase Reference Standards
α-Angelica lactone (Standard) is the analytical standard of α-Angelica lactone. This product is intended for research and analytical applications. α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

HY-113216R

Asymmetric dimethylarginine (Standard) NG,NG-Dimethylarginine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite NO Synthase
Hesperetin (Standard) is the analytical standard of Hesperetin. This product is intended for research and analytical applications. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis.

HY-N13388

5-Hydroxytryptophol-O-glucuronide UGT1A6	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Biochemical Assay Reagents
5-Hydroxytryptophol-O-glucuronide is an authentic glucuronide standard and probe metabolite. 5-Hydroxytryptophol-O-glucuronide is used to detect the activity of human *UGT1A6* in in vitro systems including human liver microsomes and recombinant *UGT1A6* .

HY-N0372R

Licochalcone A (Standard)	Structural Classification Chalcones Flavonoids Leguminosae Plants Glycyrrhiza uralensis Fisch. Source Classification	Reference Standards Autophagy
Licochalcone A (Standard) is the analytical standard of Licochalcone A. This product is intended for research and analytical applications. Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and Ki values lower than 5 μM) .

HY-N0235R

Bakuchiol (Standard) (S)-(+)-Bakuchiol (Standard)	Structural Classification Monophenols Leguminosae Phenols Psoralea corylifolia L. Plants Source Classification	Carboxylesterase (CES) Reference Standards p38 MAPK Autophagy UGT
Bakuchiol (Standard) is the analytical standard of Bakuchiol. This product is intended for research and analytical applications. Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC₅₀s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory , antibacterial , antitumor therapies, as well as drug metabolism regulation.

HY-125129

Carlinoside	Flavonoids Classification of Application Fields Flavones Cymbopogon citratus Gramineae Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Keap1-Nrf2
Carlinoside is a flavone glycoside with hepatoprotective efficiency. Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. Carlinoside has the potential to intervene hyperbilirubinemia due to liver dysfunction .

HY-N10754

Aschantin	Structural Classification Magnoliaceae Lignans Yulania biondii (Pamp.) D. L. Fu Phenylpropanoids Plants Source Classification	mTOR Cytochrome P450
Aschantin, a bisepoxylignan, can be isolated from Magnolia biondii. Aschantin has antiplasmodial, Ca ²⁺-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. Aschantin is a mTOR kinase inhibitor. Aschantin is also an inhibitor of Cytochrome P450 and *UGT* enzyme .

HY-N3989

Haplopine	Infection Alkaloids Structural Classification Monophenols other families Classification of Application Fields Phenols Quinoline Alkaloids Plants Disease Research Fields Source Classification	Bacterial UGT Interleukin Related SOD COX
Haplopine is a substance with anti-inflammatory, antioxidant and photoactivated antibacterial activities. It also acts as an inhibitor of *UGT1A7* and a photoactivated restriction endonuclease inhibitor. Haplopine inhibits the mRNA/protein expression of IL-6, TSLP, GM-CSF, G-CSF, IL-4, IL-13 and COX-2, while upregulating the mRNA/protein expression of SOD, CAT and HO-1. Haplopine inhibits the glucuronidation reaction catalyzed by *UGT1A7* through competitive hydrophobic binding. Haplopine exerts photoactivated restriction endonuclease inhibitory effects by binding to DNA. Haplopine exhibits photoactivated activity against methicillin-resistant Staphylococcus aureus. Haplopine alleviates symptoms of atopic dermatitis. Haplopine can be used in research related to atopic dermatitis and methicillin-resistant Staphylococcus aureus infections .

HY-N2574R

Gitogenin (Standard)	Tribulus terrester Linn. Structural Classification Zygophyllaceae Plants Steroids Source Classification	Reference Standards Glycosidase
Gitogenin (Standard) is the analytical standard of Gitogenin. This product is intended for research and analytical applications. Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC₅₀ values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms .

HY-N0859R

Schisanhenol (Standard) Schizanhenol (Standard); Gomisin-K3 (Standard)	Structural Classification Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Source Classification	UGT Reference Standards Cholinesterase (ChE) Tau Protein SOD Sirtuin
Schisanhenol (Standard) (Schizanhenol (Standard)) is the analytical standard of Schisanhenol (HY-N0859). This product is intended for research and analytical applications. Schisanhenol, a lignan, is an orally active antioxidant. Schisanhenol reduces AChE activity, increases SIRT1 and PGC-1α expression, and decreases phosphorylated Tau (Ser 396) levels. Schisanhenol increases SOD and glutathione peroxidase activity, decreases malondialdehyde (MDA) content, and inhibits UGT2B7 activitY. Schisanhenol attenuates ox-LDL-induced apoptosis, intracellular reactive oxygen species generation, and cytotoxicity in endothelial cells. Schisanhenol inhibits LDL oxidation, brain mitochondrial and membrane peroxidative damage, and brain mitochondrial swelling and disintegration. Schisanhenol can be used for the research of Alzheimer’s disease, atherosclerosis, brain ischemia, and age-related brain deterioration.

HY-W777236

N-Acetyl serotonin β-D-glucuronide	Structural Classification Natural Products Selaginellaceae Plants Selaginella tamariscina (P. Beauv.) Spring Source Classification	Drug Metabolite
N-Acetyl serotonin β-D-glucuronide is a glucuronidated metabolite of N-acetylserotonin (HY-107854) and a probe metabolite for *UGT1A6* activity assays.N-Acetyl serotonin β-D-glucuronide forms from N-acetyl serotonin via glucuronidation catalyzed by a UGT enzyme .

HY-N19800

Anhydroicaritin-3,7-di-O-glucuronide	Structural Classification Flavonols Flavonoids Endogenous metabolite Source Classification	Drug Metabolite
Anhydroicaritin-3,7-di-O-glucuronide is a diglucuronide metabolite of icaritin. Anhydroicaritin-3,7-di-O-glucuronide is also a conjugated metabolite derived from prenylated flavonoids of the genus Epimedium in rats. In an in vitro microsomal system, Anhydroicaritin-3,7-di-O-glucuronide is mainly catalyzed by *UGT1A1* and *UGT1A8*. Anhydroicaritin-3,7-di-O-glucuronide is generated via sequential glucuronidation at the 3-OH and 7-OH sites of icaritin, or via further conversion from monoglucuronides of icaritin .

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HY-P702034

	SLC35A2 Protein, Human (sf9, His, MBP, FLAG) SLC35A2; UDP-galactose translocator; Solute carrier family 35 member A2; UDP-galactose transporter; UDP-Gal-Tr; UGT	Human	Sf9 insect cells
	SLC35A2 is a key transmembrane protein that acts as an antiporter to transport uridine diphosphate galactose (UDP-galactose) into the Golgi apparatus. The process involves the exchange of UDP-galactose with UMP and exhibits versatility through exchange with AMP and CMP. SLC35A2 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC35A2 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-137083S

Trifluoperazine N-glucuronide-d3
Trifluoperazine N-glucuronide-d₃ is deuterium labeled Trifluoperazine N-Glucuronide. Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation .

HY-N0168S

Hesperetin-d3
Hesperetin-d₃ is the deuterium labeled Hesperetin . Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis .

HY-137522S

Zidovudine O-β-D-glucuronide-d3 sodium

Zidovudine O-β-D-glucuronide-d₃ sodium (3'-Azido-3'-deoxythymidine β-D-glucuronide-d₃ sodium) is a deuterium labeled Zidovudine O-β-D-glucuronide sodium (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

HY-135582S

Raloxifene 4'-glucuronide-d4

Raloxifene 4'-glucuronide-d₄ is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-135582S1

Raloxifene 4'-glucuronide-d4 lithium

Raloxifene 4'-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 4'-glucuronide. Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-135581S1

Raloxifene 6-glucuronide-d4 lithium

Raloxifene 6-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC₅₀ of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

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HY-P89950

	UGT1A6 Antibody (YA9294)	WB, ICC/IF, IF-Tissue, IP, ELISA	human
	UGT1A6 Antibody (YA9294) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to UGT1A6.