80-92-2
Chemical Structure
Pregnanediol
Synonym(s): NSC 1612; NSC 47462
- CAS No.: 80-92-2
- Formula:C21H36O2
- Molecular Weight:320.51
IUPAC Name: (3R,5R,8R,9S,10S,13S,14S,17S)-17-((S)-1-hydroxyethyl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-ol
InChIKey: YWYQTGBBEZQBGO-BERLURQNSA-N
SMILES: C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@H](O)CC2)([H])[C@@]4([H])[C@@](C)([C@]([C@@H](O)C)([H])CC4)CC3
Biological Activity: Pregnanediol (NSC 1612) is a Progesterone (HY-N0437) metabolite. Pregnanediol does not affect the transcriptional activity of UGT1A1 enhancer-promoter complex of WT and variant type. pregnanediol inhibits glucuronidation activity of G71R-UGT1A1. Pregnanediol is a cause of breast milk jaundice in carriers of G71R[1][2].
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Pregnanediol | 99.97% | Pregnanediol (NSC 1612) is a Progesterone (HY-N0437) metabolite. Pregnanediol does not affect the transcriptional activity of UGT1A1 enhancer-promoter complex of WT and variant type. pregnanediol inhibits glucuronidation activity of G71R-UGT1A1. Pregnanediol is a cause of breast milk jaundice in carriers of G71R. | ||||||||||||||||||||
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Pregnanediol (Standard) | ≥98% | Pregnanediol (Standard) is the analytical standard of Pregnanediol. This product is intended for research and analytical applications. Pregnanediol is the major metabolite of progesterone and can be excreted via urine. Pregnanediol offers an indirect way to measure progesterone levels in vivo. | ||||||||||||||||||||
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Pregnanediol-d5 | Pregnanediol-d5 is the deuterium labeled Pregnanediol. Pregnanediol is the major metabolite of progesterone and can be excreted via urine. Pregnanediol offers an indirect way to measure progesterone levels in vivo. | |||||||||||||||||||||
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- [1]. Ota Y, et al. Inhibitory effect of 5β-pregnane-3α,20β-diol on transcriptional activity and enzyme activity of human bilirubin UDP-glucuronosyltransferase. Pediatr Res. 2011 Nov;70(5):453-7. [Content Brief]
- [2]. Zhang K, et al. Determination of two progestin metabolites (17α-hydroxypregnanolone and pregnanediol) and different classes of steroids (androgens, estrogens, corticosteroids, progestins) in rivers and wastewaters by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Sci Total Environ. 2018 Jan 1;610-611:1164-1172. [Content Brief]
