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UGT8-IN-1 

Cat. No.: HY-131703
Handling Instructions

UGT8-IN-1 is a brain penetrable and orally active inhibitor of ceramide galactosyltransferase enzyme (UGT8). UGT8-IN-1 can be used in the study for lysosomal storage disorders.

For research use only. We do not sell to patients.

UGT8-IN-1 Chemical Structure

UGT8-IN-1 Chemical Structure

CAS No. : 2414349-93-0

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Description

UGT8-IN-1 is a brain penetrable and orally active inhibitor of ceramide galactosyltransferase enzyme (UGT8). UGT8-IN-1 can be used in the study for lysosomal storage disorders[1].

In Vivo

UGT8-IN-1 (compound 19) exhibits the T1/2 of 4.3 h, 1.13 h and 13.6 h by iv (1 mg/kg) administration in rat, mouse and dog, respectively. UGT8-IN-1 (compound 19) shows F% of 40%, 34% and 52% by oral (3 mg/kg) administration in rat, mouse and dog, respectively[1].
UGT8-IN-1 (compound 19, orally twice a day for three days) shows ≥90% inhibition of incorporation of 13C-Gal into GalCer and SFT, at all three doses tested, with the estimated ED50s of <3 mg/kg for inhibition of both SFT and GalCer. UGT8-IN-1 (compound 19) has very high plasma protein and tissue binding (>99%)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

528.47

Formula

C₂₀H₂₂F₆N₄O₄S

CAS No.

2414349-93-0

SMILES

O=C(OC1CCN(C2=CC(C(F)(F)F)=C3C(C(C(NC)=O)=CS3)=N2)CC1)N[[email protected]@H](C)COC(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

UGT8-IN-1OtherslysosomalstoragedisordersceramidegalactosyltransferaseInhibitorinhibitorinhibit

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