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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
achondroplasia
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "achondroplasia" in MCE Product Catalog:
Cat. No.: HY-P3503
CAS No.: 1480724-61-5
Synonyms: BMN 111
Cat. No.: HY-159642
CAS No.: 2800223-30-5
Synonyms: TYRA-300
Research Areas:
Dabogratinib (TYRA-300) is an orally active, selective FGFR3 inhibitor with an IC50 of 11 nM. Dabogratinib exhibits antitumor activity against urothelial carcinoma and solid tumors. Dabogratinib downregulates the FGFR3 and ERK1/2 signaling pathways, and induces tumor growth inhibition and regression in FGFR3-altered xenograft models. Dabogratinib promotes chondrocyte proliferation and differentiation, drives endochondral bone formation and overall body growth, partially restores long bone proportions, and improves craniofacial and spinal morphology. Dabogratinib can be used for the research of metastatic urothelial carcinoma, achondroplasia and hypochondroplasia .
Cat. No.: HY-P99823
CAS No.: 2226238-09-9
Synonyms: TA-46; sFGFR3
Cat. No.: HY-176547
CAS No.: 3069945-78-1
Target:
Research Areas:
FGFR2/3-IN-3 is a dual-target FGFR2/3 inhibitor with IC50s of 2.7 nM (TEL-FGFR2) and 3.9 nM (TEL-FGFR3), respectively. FGFR2/3-IN-3 has effective activity against both wild-type and mutant FGFR3. FGFR2/3-IN-3 has low CYP3A4 inhibitory effect and hERG toxicity. FGFR2/3-IN-3 improves the imbalance between chondrocyte proliferation and differentiation and promotes bone growth by inhibiting the signaling pathway mediated by mutant FGFR3. FGFR2/3-IN-3 shows a growth-promoting effect in a dwarfism mouse model and has the potential to study bone development disorder-related diseases such as achondroplasia (ACH) .
Cat. No.: HY-122833
CAS No.: 2833703-74-3
Target:
Research Areas:
FGFR3-IN-10 is a FGFR3 inhibitor with an IC50 of <350 nM. FGFR3-IN-10 is applicable to research related to cancer, systemic sclerosis, fibrosis, achondroplasia, thanatophoric dysplasia, and Muenke syndrome .
Cat. No.: HY-P706050
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: FGFR3; Mutant Fibroblast Growth Factor Receptor 3; Prev. ACH; Fibroblast Growth Factor Receptor 3-S; JTK4; Fibroblast Growth Factor Receptor; CD333; Receptor Protein-Tyrosine Kinase; CEK2; Hydroxyaryl-Protein Kinase; FGFR-3; Tyrosine Kinase JTK4; Fibroblast Growth Factor Receptor 3 Isoform C; CD333 Antigen; Fibroblast Growth Factor Receptor 3 Isoform B; HSFGFR3EX; Fibroblast Growth Factor Receptor 3; achondroplasia, Thanatophoric Dwarfism
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706051
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: FGFR3; Mutant Fibroblast Growth Factor Receptor 3; Prev. ACH; Fibroblast Growth Factor Receptor 3-S; JTK4; Fibroblast Growth Factor Receptor; CD333; Receptor Protein-Tyrosine Kinase; CEK2; Hydroxyaryl-Protein Kinase; FGFR-3; Tyrosine Kinase JTK4; Fibroblast Growth Factor Receptor 3 Isoform C; CD333 Antigen; Fibroblast Growth Factor Receptor 3 Isoform B; HSFGFR3EX; Fibroblast Growth Factor Receptor 3; achondroplasia, Thanatophoric Dwarfism
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706052
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: FGFR3; Mutant Fibroblast Growth Factor Receptor 3; Prev. ACH; Fibroblast Growth Factor Receptor 3-S; JTK4; Fibroblast Growth Factor Receptor; CD333; Receptor Protein-Tyrosine Kinase; CEK2; Hydroxyaryl-Protein Kinase; FGFR-3; Tyrosine Kinase JTK4; Fibroblast Growth Factor Receptor 3 Isoform C; CD333 Antigen; Fibroblast Growth Factor Receptor 3 Isoform B; HSFGFR3EX; Fibroblast Growth Factor Receptor 3; achondroplasia, Thanatophoric Dwarfism
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706053
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: FGFR3; Mutant Fibroblast Growth Factor Receptor 3; Prev. ACH; Fibroblast Growth Factor Receptor 3-S; JTK4; Fibroblast Growth Factor Receptor; CD333; Receptor Protein-Tyrosine Kinase; CEK2; Hydroxyaryl-Protein Kinase; FGFR-3; Tyrosine Kinase JTK4; Fibroblast Growth Factor Receptor 3 Isoform C; CD333 Antigen; Fibroblast Growth Factor Receptor 3 Isoform B; HSFGFR3EX; Fibroblast Growth Factor Receptor 3; achondroplasia, Thanatophoric Dwarfism
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
