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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
active uptake transporters
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "active uptake transporters" in MCE Product Catalog:
4
4
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2 Cited Publications
Cat. No.: HY-B1080A
CAS No.: 27591-97-5
Target:
Research Areas:
Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Tilorone is an orally active antiviral agent and interferon inducer that also has potential antineoplastic, immunomodulatory, and metabolic modulating effects. Tilorone induces an abnormally delayed interferon response and primarily stimulates interferon production in lymphoid tissue. Thus, Tilorone exerts antiviral effects and can be used as a chemotherapeutic agent. Tilorone has the potential to inhibit type 2 diabetes by increasing glucose uptake in vivo and in skeletal muscle cells by enhancing Akt2/AS160 signaling and glucose transporter levels .
Cat. No.: HY-B0396
CAS No.: 161715-24-8
Synonyms: L084
Target:
Research Areas:
Tebipenem pivoxil (L084 hydrobromide) is an orally active carbapenem Antibiotic. Tebipenem pivoxil acts as a substrate of OATP1A2 with high affinity for this transporter (Km = 41.1 μM) . Tebipenem pivoxil achieves intestinal absorption via carrier-mediated uptake and simple diffusion. Tebipenem pivoxil inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, multidrug-resistant bacteria, and pathogens producing extended-spectrum β-lactamases. Tebipenem pivoxil eliminates intestinal infection pathogens and reduces mortality in septic mice. Tebipenem pivoxil can be used in research related to bacterial pneumonia, severe gastrointestinal infections, bacterial sepsis, complicated urinary tract infections, and acute pyelonephritis .
Cat. No.: HY-124030
CAS No.: 70030-11-4
Target:
Research Areas:
3-Hydroxyphenazepam is an active metabolite of Cinazepam. Cinazepam is a GABAA receptor agonist. 3-Hydroxyphenazepam can inhibit synaptosomal transporter-mediated [ 3H]GABA uptake .
Cat. No.: HY-W008385
CAS No.: 156-86-5
Synonyms: L-Homoarginine
Cat. No.: HY-W012340S
CAS No.: 2483830-23-3
Synonyms: L-Homoarginine-13C7,15N4 hydrochloride
H-HomoArg-OH- 13C7, 15N4 hydrochloride (L-Homoarginine- 13C7, 15N4 hydrochloride) is the 15N, 13C-labeled H-HomoArg-OH (hydrochloride) (HY-W012340). H-HomoArg-OH hydrochloride (L-Homoarginine hydrochloride) is an orally active endogenous non-protein amino acid. H-HomoArg-OH hydrochloride acts as a weak alternative substrate for NOS and interferes with NO production, selectively inhibits tissue-nonspecific alkaline phosphatase (TNAP), and suppresses the uptake of arginine by y +-type transporters (system y +). H-HomoArg-OH hydrochloride increases tissue hArg concentrations in vivo, regulates amino acid homeostasis, and improves renal function and pathological features of diabetic nephropathy. H-HomoArg-OH hydrochloride can be used in studies related to diabetes and cardiomyopathy .
Cat. No.: HY-B0590B
CAS No.: 1026016-83-0
Synonyms: (+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine
Target:
Research Areas:
(+)-Tetrabenazine ((+)-TBZ) is the enantiomer of Tetrabenazine (HY-B0590) and is also a Vesicular Monoamine Transporter 2 (VMAT2) inhibitor with a rat Ki of 4.61 nM. (+)-Tetrabenazine inhibits monoamine uptake into granular vesicles of presynaptic neurons. (+)-Tetrabenazine is 3 times more active than (-)-Tetrabenazine. (+)-Tetrabenazine can be used for the research of Huntington's disease and hyperkinetic movement disorders (including chorea) .
Cat. No.: HY-W012340
CAS No.: 1483-01-8
Synonyms: L-Homoarginine hydrochloride
Synonyms: TD-9855 hydrochloride
Target:
Research Areas:
Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC50 values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma .
Cat. No.: HY-W008385R
CAS No.: 156-86-5
Synonyms: L-Homoarginine (Standard)
Cat. No.: HY-W008385S
CAS No.: 1332075-41-8
Synonyms: L-Homoarginine-d4
Research Areas:
H-HoArg-OH-d4 (L-Homoarginine-d4) is the d4-labeled H-HoArg-OH (HY-W008385). H-HoArg-OH (L-Homoarginine) is an orally active endogenous non-protein amino acid. H-HoArg-OH acts as a weak alternative substrate for NOS and interferes with NO production, selectively inhibits tissue-nonspecific alkaline phosphatase (TNAP), and suppresses the uptake of arginine by y +-type transporters (system y +). H-HoArg-OH increases tissue hArg concentrations in vivo, regulates amino acid homeostasis, and improves renal function and pathological features of diabetic nephropathy. H-HoArg-OH can be used in studies related to diabetes and cardiomyopathy .
Cat. No.: HY-B0396A
CAS No.: 211558-19-9
Synonyms: L084 hydrochloride
Target:
Research Areas:
Tebipenem pivoxil hydrochloride (L084 hydrochloride) is an orally active carbapenem Antibiotic. Tebipenem pivoxil hydrochloride acts as a substrate of OATP1A2 with high affinity for this transporter (Km = 41.1 μM) . Tebipenem pivoxil hydrochloride achieves intestinal absorption via carrier-mediated uptake and simple diffusion. Tebipenem pivoxil hydrochloride inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, multidrug-resistant bacteria, and pathogens producing extended-spectrum β-lactamases. Tebipenem pivoxil hydrochloride eliminates intestinal infection pathogens and reduces mortality in septic mice. Tebipenem pivoxil hydrochloride can be used in research related to bacterial pneumonia, severe gastrointestinal infections, bacterial sepsis, complicated urinary tract infections, and acute pyelonephritis .
Cat. No.: HY-W008385AS
Synonyms: L-Homoarginine-d4 dihydrochloride
H-HoArg-OH-d4 dihydrochloride (L-Homoarginine-d4 dihydrochloride) is the d4-labeled H-HoArg-OH dihydrochloride. H-HoArg-OH dihydrochloride (L-Homoarginine dihydrochloride) is an orally active endogenous non-protein amino acid. H-HoArg-OH dihydrochloride acts as a weak alternative substrate for NOS and interferes with NO production, selectively inhibits tissue-nonspecific alkaline phosphatase (TNAP), and suppresses the uptake of arginine by y +-type transporters (system y +). H-HoArg-OH dihydrochloride increases tissue hArg concentrations in vivo, regulates amino acid homeostasis, and improves renal function and pathological features of diabetic nephropathy. H-HoArg-OH dihydrochloride can be used in studies related to diabetes and cardiomyopathy .
Cat. No.: HY-173344
Target:
Research Areas:
DB-10 is a pro-agent of 3-nbutylphthalide (NBP) (HY-B0647). DB-10 has significantly high uptake ability via pyrilamine cationic transporters in the temperature and energy dependent manner in cells. DB-10 improves the survival rate of cells. DB-10 could rapidly convert into active original agent and increase the accumulation in the brain in vivo. DB-10 can be used for ischemic stroke study .
Cat. No.: HY-107128R
CAS No.: 1227056-87-2
Synonyms: TD-9855 hydrochloride (Standard)
Research Areas:
Ampreloxetine hydrochloride (Standard) (TD-9855 hydrochloride (Standard)) is the analytical standard of Ampreloxetine (hydrochloride) (HY-107128). This product is intended for research and analytical applications. Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC50 values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma .
Cat. No.: HY-W012340R
CAS No.: 1483-01-8
Cat. No.: HY-B0396R
CAS No.: 161715-24-8
Synonyms: L084 (Standard)
Target:
Research Areas:
Tebipenem pivoxil (Standard) (L084 (Standard)) is the analytical standard of Tebipenem pivoxil (HY-B0396). This product is intended for research and analytical applications. Tebipenem pivoxil (L084 hydrobromide) is an orally active carbapenem Antibiotic. Tebipenem pivoxil acts as a substrate of OATP1A2 with high affinity for this transporter (Km = 41.1 μM) . Tebipenem pivoxil achieves intestinal absorption via carrier-mediated uptake and simple diffusion. Tebipenem pivoxil inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, multidrug-resistant bacteria, and pathogens producing extended-spectrum β-lactamases. Tebipenem pivoxil eliminates intestinal infection pathogens and reduces mortality in septic mice. Tebipenem pivoxil can be used in research related to bacterial pneumonia, severe gastrointestinal infections, bacterial sepsis, complicated urinary tract infections, and acute pyelonephritis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
