Search Result

Results for "

alpha-tubulin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Apoptosis (27) Autophagy (2) Bcl-2 Family (4) Biochemical Assay Reagents (1) c-Myc (1) Carbonic Anhydrase (1) Casein Kinase (1) Caspase (8) Collagen (1) COX (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) EGFR (1) Endogenous Metabolite (2) Fatty Acid Synthase (FASN) (1) Fungal (1) HDAC (35) Histone Acetyltransferase (2) Histone Methyltransferase (2) HSP (2) Interleukin Related (2) JNK (1) Keap1-Nrf2 (1) Microtubule/Tubulin (32) Mitochondrial Metabolism (1) Parasite (1) PARP (1) PD-1/PD-L1 (2) PI3K (2) PPAR (1) PROTACs (2) Proteasome (1) Reactive Oxygen Species (ROS) (2) Sirtuin (5) Tau Protein (1) Topoisomerase (1) VEGFR (1)
By Research Areas:	Cancer (49) Cardiovascular Disease (3) Endocrinology (2) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (5)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Peptides

Natural
Products

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155956

GM-90257 1 Publications Verification	Microtubule/Tubulin Apoptosis Bcl-2 Family JNK PARP	Cancer
GM-90257 is a microtubule acetylation inhibitor. GM-90257 binds directly to *α-tubulin. GM-90257 prevents the recruitment of α-tubulin* acetyltransferase 1 (αTAT1) to the K40 residue in α-tubulin. GM-90257 causes Apoptosis, downregulates BCl-2, and activates JNK and PARP. GM-90257 has anticancer activity against breast cancer .

HY-13265

AR-42 4 Publications Verification HDAC-42; OSU-HDAC42	HDAC Autophagy Apoptosis	Cancer
AR-42 (HDAC-42; OSU-HDAC42) is a potent, orally bioavailable pan-HDAC inhibitor (IC₅₀=16 nM). AR-42 induces growth inhibition, cell-cycle arrest, apoptosis, and activation of caspases-3/7. AR-42 promotes hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21. AR-42 shows cytotoxicity against various human cancer cell lines .

HY-116446

Pironetin	Microtubule/Tubulin	Cancer
Pironetin is an α/β unsaturated lactone isolated from Streptomyces species. Pironetin binds to *α-tubulin* and is a potent inhibitor of microtubule polymerization, and has cell cycle arrest and antitumor activity .

HY-132242

DL-Sulforaphane N-acetyl-L-cysteine SFN-NAC	HDAC Apoptosis Drug Metabolite	Cancer
DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is an orally active HDAC inhibitor and metabolite of sulforaphane (HY-13755) with longer half-life and better blood-brain barrier permeability. DL-Sulforaphane N-acetyl-L-cysteine activates autophagy-mediated downregulation of α-tubulin expression through the ERK pathway and can be used in cancer research .

HY-152134

HDAC6 degrader-3	HDAC PROTACs	Cancer
HDAC6 degrader-3 is a potent and selective HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with a DC₅₀ value of 19.4 nM. HDAC6 degrader-3 has IC₅₀s of 4.54 nM and 0.647 μM for HDAC6 and HDAC1, respectively. HDAC6 degrader-3 causes strong hyperacetylation of α-tubulin .

HY-116568

Prothioconazole JAU-6476	Fungal Cytochrome P450 Microtubule/Tubulin Mitochondrial Metabolism DNA/RNA Synthesis Apoptosis Fatty Acid Synthase (FASN)	Infection Metabolic Disease Endocrinology
Prothioconazole is an orally active broad-spectrum fungicide. Prothioconazole weakly inhibits CaCYP51 activity in Candida albicans, with an apparent IC₅₀ of approximately 120 μM. Prothioconazole disrupts Microtubule stability by reducing the acetylation level of α-tubulin. Prothioconazole induces Mitochondrial dysfunction, oxidative stress, DNA damage, and Apoptosis. Prothioconazole accumulates ¹⁴-methylated sterols and depletes ergosterol in cells, culture media, plants, and animals. Prothioconazole interferes with pyruvate metabolism and glycolysis/gluconeogenesis processes in mouse liver, downregulates Fasn mRNA expression, and induces hepatotoxicity and renal metabolic disorders. Prothioconazole reduces the fertility of female mice. Prothioconazole inhibits body weight gain and increases liver/kidney indices in mice. Prothioconazole can be used in studies related to candidiasis .

HY-148542

EpoY SD-142	Endogenous Metabolite	Cardiovascular Disease Cancer
EpoY (SD-142) acts as an irreversible inhibitor of the brain's primary tubulin tyrosine carboxypeptidase (TCP), a complex formed by vasohibin-1 (VASH1) and the small vasohibin binding protein (SVBP). By inhibiting TCP with an IC₅₀ value of approximately 500 nM, EpoY effectively decreases levels of detyrosinated alpha-tubulin, which is crucial for microtubule dynamics and neuronal differentiation. This inhibition leads to significant differentiation defects and has been linked to underlying issues associated with cancer and cardiomyopathies.

HY-171140

PROTAC HDAC6 degrader 3	PROTACs HDAC	Cancer
PROTAC HDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader for HDAC6 with an IC₅₀ of 686 nM and a DC₅₀ of 171 nM. PROTAC HDAC6 degrader 3 promotes the acetylation of α-tubulin . (Pink: ligand for target protein (HY-171141); Blue: ligand for E3 ligase VHL (HY-150803))

HY-176540

Microtubule stabilizer-1	Microtubule/Tubulin	Neurological Disease
Microtubule stabilizer-1 (compound 69) is a brain-penetrant microtubule (MT) stabilizer. Microtubule stabilizer-1 increases acetylated α-tubulin (AcTub) levels and prevents the characteristic loss of neuronal MTs that is observed after incubation with Okadaic acid (HY-N6785). Microtubule stabilizer-1 can be used for the study of Alzheimer’s disease (AD) and related neurodegenerative tauopathies .

HY-112806

ST8155AA1	Drug-Linker Conjugates for ADC HDAC EGFR Microtubule/Tubulin	Cancer
ST8155AA1 is a part of antibody agent conjugates (ADCs) charged with HDAC inhibitor. ST8155AA1 induces *α-tubulin, histone H3/H4 acetylation via direct enzymatic inhibition. ST8155AA1 recognizes and binds EGFR*, undergoes internalization into EGFR-expressing tumor cells. ST8155AA1 inhibits cancer cell proliferation and exerts activity in mouse tumor models. ST8155AA1 can be used for the research of non-small cell lung cancer .

HY-155727

Sirt1/2-IN-2	Sirtuin Apoptosis	Cancer
Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC₅₀s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines .

HY-179019

HDAC-IN-94	HDAC Microtubule/Tubulin Apoptosis Caspase	Neurological Disease Cancer
HDAC-IN-94 is a potent, selective HDAC6 inhibitor (IC₅₀ = 4.5 nM). HDAC-IN-94 shows >1000-fold selectivity over HDAC8 and shows minimal activity against other isoforms (HDAC1-3/10). HDAC-IN-94 induces *α-tubulin* hyperacetylation, apoptosis, and G2/M cell cycle arrest, exhibiting potent anti-tumor efficacy with low cytotoxicity. HDAC-IN-94 can be used for neuroblastoma and glioblastoma research .

HY-176561

IOR-160	Casein Kinase HDAC	Cancer
IOR-160 is a dual inhibitor of casein kinase 2 (CK2) and HDACs. IOR-160 exhibits high selectivity for CK2 (IC₅₀ = 1.7 nM) and broad inhibitory activity against HDAC (HDAC 1, 2, 3, and 6 with IC₅₀s of 3.3 nM, 24.0 nM, 3.9 nM, and 13.0 nM, respectively, with low activity for HDAC8). IOR-160 modulates key cellular signaling pathways by inhibiting AKT phosphorylation and increasing acetylated α-tubulin. IOR-160 inhibits tumor growth and reduces tumor burden through dual CK2/HDAC inhibition. IOR-160 is indicated for use in triple-negative breast cancer research .

HY-178333

HDAC6-IN-66	HDAC	Cancer
HDAC6-IN-66 is a potent and selective histone deacetylase (HDAC) 6 inhibitor with an IC₅₀ of 1.8 nM. HDAC6-IN-66 induces α-tubulin acetylation over histone H3. HDAC6-IN-66 can be used for the research of cancer .

HY-146013

Sirt1/2-IN-1	Sirtuin Microtubule/Tubulin	Cancer
Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC₅₀ values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC₅₀ of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity .

HY-178110

HDAC6-IN-65	HDAC Microtubule/Tubulin Histone Methyltransferase	Cancer
HDAC6-IN-65 is a selective HDAC6 inhibitor (IC₅₀ = 0.9 nM) and also exhibits a certain suppressive effect on HDAC3 (IC₅₀ = 39.4 nM). HDAC6-IN-65 can induce the accumulation of **α-tubulin (ac-tubulin) and acetylated histone H3 (ac-histone H3**, a class I HDAC inhibition marker) in Neuro-2a cells. HDAC6-IN-65 can be used for the study of melanoma .

HY-178351

HDAC6-IN-67	HDAC Microtubule/Tubulin Apoptosis Caspase Bcl-2 Family	Cancer
HDAC6-IN-67 is a selective HDAC6 inhibitor (IC50 = 17.15 nM) that exhibits 19-fold selectivity over HDAC1. HDAC6-IN-67 selectively inhibits HDAC6 by interacting with Ser531 and His614. HDAC6-IN-67 induces apoptosis by inducing the cleavage of caspases 9, 8, 3, and PARP, upregulating Bax expression, and downregulating Bcl-2 expression. HDAC6-IN-67 effectively induces the acetylation of *α-tubulin*, without affecting histone H3 acetylation in MCF-7/ADR cells. HDAC6-IN-67 can be used for the study of breast cancer .

HY-173039

α-Tubulin polymerization-IN-1	Microtubule/Tubulin Keap1-Nrf2 Reactive Oxygen Species (ROS) Apoptosis	Cancer
α-Tubulin polymerization-IN-1 (Compound 8l) is an inhibitor for α-Tubulin polymerization. α-Tubulin polymerization-IN-1 modulates the NRF2/KEAP-1 signaling pathway, induces ROS generation in PC-3 cell, thereby inducing apoptosis in PC-3. α-Tubulin polymerization-IN-1 inhibits the proliferation of PC-3 cell with a GI₅₀ of 0.17 µM, arrests the cell cycle at G2/M phase. α-Tubulin polymerization-IN-1 exhibits antitumor efficacy in mouse model .

HY-D1710

*Anti-α-Tubulin* Antibody, AF555 conjugate**	Microtubule/Tubulin	Others
Anti-α-Tubulin Antibody, AF555 conjugate is a conjugate of mouse anti-α-tubulin monoclonal antibody and the red fluorescent dye Alexa Fluor 555. Anti-α-Tubulin Antibody, AF555 conjugate can be used for the detection of *tubulin* (Ex/Em: 554/567 nm) .

HY-174396

PI3Kδ/HDAC6-IN-1	PI3K HDAC Bcl-2 Family Caspase Reactive Oxygen Species (ROS) Apoptosis Histone Methyltransferase Microtubule/Tubulin	Cancer
PI3Kδ/HDAC6-IN-1 (Compound 22E) is an orally active and dual inhibitor of PI3Kδ and HDAC6 with IC₅₀ values of 2.4 nM and 6.2 nM, respectively. PI3Kδ/HDAC6-IN-1 exhibits potent antiproliferative effects on non-Hodgkin lymphoma (NHL) cells and possesses in vivo antitumor activity without significant toxicity. PI3Kδ/HDAC6-IN-1 arrests the cell cycle at the G0/G1 phase and induces apoptosis. PI3Kδ/HDAC6-IN-1 blocks the PI3K/AKT/mTOR signaling pathway and increases the acetylation levels of α-tubulin and histone H3 .

HY-152089

SB26019	Microtubule/Tubulin	Neurological Disease Inflammation/Immunology
SB26019 is a potent anti-neuroinflammatory agent. SB26019 regulates NF-κB activation by inducing monomeric *α-tubulin* formation. SB26019-induced α-tubulin monomer inhibits p65 translocation .

HY-124946

C1A	HDAC Sirtuin Apoptosis	Cancer
C1A is a class I/II HDACs and sirtuin inhibitor with an IC₅₀ of 479 nM for HDAC6. C1A induces sustained acetylation of HDAC6 substrates, α-tubulin and HSP90. C1A shows srtong anticancer effcts, and induces apoptosis in cancer cells .

HY-158308

HDAC6-IN-41	HDAC	Cancer
HDAC6-IN-41 (Compound E24) is a selective inhibitor for histone deacetylase 6 (HDAC6), with IC₅₀ of 14 and 422 nM, for HDAC6 and HDAC8, respectively. HDAC6-IN-41 upregulates the acetylation of α-tubulin and histone site SMC3 .

HY-169922

HDAC-IN-82	HDAC Parasite Caspase	Cancer
HDAC-IN-82 (Compound 18b) is a histone deacetylase (HDAC) inhibitor with selective antiplasmodial and anticancer activity. HDAC-IN-82 shows potent antiproliferative activity and caspase 3/7 activation in cancer cells. HDAC-IN-82 causes hyperacetylation of histone H3 and α-tubulin .

HY-151953

Antitubulin agent 1	Microtubule/Tubulin	Cancer
Antitubulin agents-1 is an antitubulin agent that induces disruption of the microtubules (Microtubule/Tubulin) and increases *α-tubulin* acetylation. Antitubulin agents-1 has anticancer effects . Antitubulin agent 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-157323

HDAC6-IN-28	HDAC Apoptosis	Cancer
HDAC6-IN-28 (compound 10C) is a potent inhibitor of HDAC6 with an IC₅₀ of 261 nM. HDAC6-IN-28 significantly induces apoptosis and S-phase arrest in B16-F10 cells. HDAC6-IN-28 efficiently increases the expression of acetylated-α-tubulin in vitro and in vivo .

HY-118295

Pyrimidine-indole hybrid	Endogenous Metabolite	Cancer
Pyrimidine-indole hybrid is a compound that inhibits ciliogenesis and has the activity of antagonizing the Hedgehog signaling pathway by destabilizing microtubules. Pyrimidine-indole hybrid exerts its biological effects by inhibiting ciliogenesis and deconstructing the stable form of α-tubulin. Pyrimidine-indole hybrid has shown its unique mechanism of action in in vitro cell experiments and zebrafish embryo models, interfering with microtubule dynamics .

HY-179525

DL78	c-Myc Microtubule/Tubulin Apoptosis	Cancer
DL78 is an effective anti-mitotic agent. DL78 induces mitotic arrest, mitotic catastrophe and apoptosis in cancer cells by disrupting the interaction between Myc and *α-tubulin*. DL78 exhibits broad anti-cancer activity, especially against cancer cells with chromosomal instability and excessive expression of MYC. DL78 significantly reduces tumor burden in the OV81.2 xenograft model. DL78 can be used for the study of ovarian cancer .

HY-163894

HDAC6-IN-48	Apoptosis HDAC	Cancer
HDAC6-IN-48 (compound 5i) is a potent and selective HDAC6 inhibitor with IC₅₀ values of 5.16, 396.72, 638.08 nM for HDAC6, HDAC3, HDAC1, respectively. HDAC6-IN-48 induces apoptosis and cell cycle arrest at G0/G1 phase. HDAC6-IN-48 increases the protein expression of acetylated α-tubulin .

HY-133147

HDAC3/6-IN-2	HDAC Apoptosis	Cancer
HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC₅₀ values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin .

HY-W749442

7a-Hydroxyfrullanolide	Microtubule/Tubulin	Cancer
7a-Hydroxyfrullanolide has anticancer properties. 7a-Hydroxyfrullanolide reduces polymerization of α-, β-tubulin. 7a-Hydroxyfrullanolide preferrs to bind to β-tubulin over α-tubulin. 7a-Hydroxyfrullanolide also triggers DNA damage response arrests cells in the G2/M-phase. 7a-Hydroxyfrullanolide is an eudesmanolide sesquiterpene lactone (SL) and can be isolated from the flowering plants of the Asteraceae family .

HY-159936

CS4	HDAC PPAR Apoptosis	Cancer
CS4 is a selective HDAC inhibitor with the IC₅₀ values of 38 nM, 12 nM, 5.8 μM, 19 μM and 61 μM against of HDAC1, HDAC6, HDAC8, HDAC4 and HDAC11, respectively. CS4 promotes *α-tubulin* and histone 3 acetylation. CS4 activates PPARγ and blocks glycolysis. CS4 induces cell cycle arrest at G2 phase and apoptosis, and shows anticancer effect both in vivo and in vitro .

HY-151153

HDAC1-IN-5	HDAC Microtubule/Tubulin Caspase Apoptosis	Cancer
HDAC1-IN-5 is a potent HDAC1 inhibitor with IC₅₀ values of 15 nM and 20 nM for HDAC1 and HDAC6, respectively. HDAC1-IN-5 can enhance the acetylation of histone H3 and *α-tubulin, as well as promote the activation of caspase 3* in cancer cells, thereby inducing apoptosis. HDAC1-IN-5 induces chromatin damage by binding with DNA. HDAC1-IN-5 has strong inhibitory activity against tumor growth in xenograft mice .

HY-155728

Sirt1/2-IN-3	Sirtuin Apoptosis	Cancer
Sirt1/2-IN-3 (compound PS9) is a dual inhibitor of SIRT1/2 with IC₅₀s of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respsectivley. Sirt1/2-IN-3 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-3 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines .

HY-P11770

α-Tubulin (residues 440–451)	Microtubule/Tubulin	Others
α-Tubulin (residues 440-451) (α-Tubulin Tail) is a Microtubule growth inhibitor. α-Tubulin (residues 440-451) transiently interacts with the longitudinal polymerization interface of *α-tubulin, regulating the apparent association and dissociation rates of tubulin* at the microtubule growing end. α-Tubulin (residues 440-451) inhibits microtubule growth .

HY-E71253

α-Tubulin N-acetyltransferase	Biochemical Assay Reagents	Others
α-Tubulin N-acetyltransferase (EC 2.3.1.108) acetylates mammalian brain α-tubulin.

HY-117688

WJ35435	HDAC Topoisomerase Apoptosis	Cancer
WJ35435 is a dual-targeted anticancer hybrid that induces anti-HDAC (in particular HDAC1 and HDAC6) and anti-topoisomerase I activities that causes DNA damage associated with a low DNA repair capability and induces cell cycle arrest at G1- and G2-phase to apoptosis. WJ35435 induces histone H3 acetylation and phosphorylation, α-tubulin acetylation and γ-H2AX formation to achieve anti-HDAC effect. WJ35435 is promising for research of cancer .

HY-163691

Antitumor agent-163	Carbonic Anhydrase	Cancer
Antitumor agent-163 (Compound 3) is a photosensitizer used in Molecular-Targeted Photodynamic Therapy (MT-PDT) targeting carbonic anhydrase IX (CAIX). Antitumor agent-163 inactivates CAIX protein via singlet oxygen under 540 nm wavelength light, without affecting internal standard proteins such as α-tubulin, β-actin, and proliferating cell nuclear antigen (PCNA). Antitumor agent-163 induces cell membrane damage, inhibits cell viability (IC₅₀ is 0.2 and 0.05 μM for A549 and U87MG). Antitumor agent-163 exhibits antitumor efficacy in mouse model .

HY-156091

PI3Kα/HDAC6-IN-1	PI3K HDAC	Cancer
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual PI3Kα/HDAC6 inhibitor with IC₅₀ of 2.9 and 26 nM, respectively. PI3Kα/HDAC6-IN-1 also inhibits AKT(Ser473) phosphorylation and induces the accumulation of acetylated α-tubulin without affecting acetylated histones H3 and H4. PI3Kα/HDAC6-IN-1 efficiently inhibits L-363 cell line (IC₅₀=0.17 μM) and has good anti-cancer activity .

HY-13614

E7974	Microtubule/Tubulin Apoptosis Caspase	Cardiovascular Disease Cancer
E7974 is a selective inhibitor of α-tubulin (α-tubulin) with an IC₅₀ of 3.9 μM. E7974 disrupts mitotic spindle formation, induces G₂-M phase cell cycle arrest, initiates apoptosis, activates caspase-3, and induces poly (ADP-ribose) polymerase cleavage. E7974 reduces the area of choroidal neovascularization in mouse models, and exerts anti-angiogenic effects when loaded in modified micelles. E7974 can be used in research related to cancer and choroidal neovascularization .

HY-123699

NCT-10b	HDAC Microtubule/Tubulin	Cancer
NCT-10b is a selective HDAC6 inhibitor. NCT-10b mediates preferential α-tubulin acetylation without major histone H4 acetylation.NCT-10b can be used for the research of multiple myeloma .

HY-182649

NN-429	HDAC Apoptosis Microtubule/Tubulin	Cancer
NN-429 is a selective HDAC6 inhibitor. NN-429 induces apoptosis, increases the acetylation level of *α-tubulin*, and exhibits cytotoxicity against cancer cells. NN-429 is applicable to research related to acute myeloid leukemia, multiple myeloma and lymphoma .

HY-121009

CCT077791	Histone Acetyltransferase Microtubule/Tubulin	Cancer
CCT077791 is a PCAF (IC₅₀: 7.3 μM (FlashPlate); 2.2 μM (Filter assay)) and p300 histone acetyltransferase inhibitor. CCT077791 reduces total acetylation of histones H3 and H4, levels of specific acetylated lysine marks, and acetylation of *α-tubulin*. CCT077791 can be used in the research of colorectal cancer .

HY-180934

AMC-3-030	HDAC Proteasome Microtubule/Tubulin	Cancer
AMC-3-030 is a selective and potent dual inhibitor targeting HDAC6 and chymotrypsin-like proteasome with IC₅₀ values of 884 and 4.17 nM. AMC-3-030 has a proliferation inhibitory effect. AMC-3-030 can reduce *α-tubulin* and β-actin levels. AMC-3-030 can be used for research of multiple myeloma .

HY-182904

GV-001	HDAC Collagen Interleukin Related Microtubule/Tubulin	Endocrinology
GV-001 is a selective and orally active HDAC6 inhibitor with an IC₅₀ of 1.18 nM against HDAC6. GV-001 selectively enhances *α-tubulin* acetylation, reduces sIL-6 and Collagen I levels, suppresses renal cyst growth, and upregulates PC1 expression. GV-001 can be used for the study of autosomal dominant polycystic kidney disease (ADPKD) .

HY-181639

HDAC6-IN-75	HDAC Apoptosis	Cancer
HDAC6-IN-75 is a selective HDAC6 inhibitor with an IC₅₀ of 0.17 nM against HDAC6. HDAC6-IN-75 induces the accumulation of acetylated *α-tubulin* in glioma cells. HDAC6-IN-75 triggers cell cycle changes, increases the SubG1 cell population, and promotes apoptosis in glioma cells and glioblastoma stem cells. HDAC6-IN-75 is applicable for glioma-related research .

HY-180214

HDAC6-IN-69	HDAC	Cardiovascular Disease Neurological Disease
HDAC6-IN-69 is a brain-penetrant and highly selective HDAC6 inhibitor with an IC₅₀ of 4.0 nM. HDAC6-IN-69 shows >176-fold against other HDAC isoforms. HDAC6-IN-69 engages the target in neuronal cells by dose-dependently upregulating acetylated α-tubulin in virto. HDAC6-IN-69 has neuroprotective effect and can be used for ischemic stroke research .

HY-153514

HDAC-IN-54	HDAC Microtubule/Tubulin Apoptosis	Cancer
HDAC-IN-54 is a HDAC inhibitor with an IC₅₀ of 25 nM against human HDAC1, 66 nM against HDAC2, 6.5 nM against HDAC3, and 281 nM against HDAC6. HDAC-IN-54 induces acetylation of *α-tubulin* and histone H3. HDAC-IN-54 acts synergistically with cisplatin to induce cancer cell apoptosis. HDAC-IN-54 can be used in research related to head and neck cancer, ovarian cancer, and tongue squamous cell carcinoma .

HY-182412

NH4-6	Sirtuin	Cancer
NH4-6 is a SIRT2 inhibitor with an IC₅₀ of 0.032 μM against SIRT2 and an IC₅₀ of 3 μM against SIRT1. NH4-6 inhibits the deacetylase activity of SIRT1. As a cytotoxic agent, NH4-6 reduces cancer cell viability, suppresses anchorage-independent growth of cancer cells, induces acetylation of *α-tubulin, and promotes acetylation of p53*. NH4-6 can be used in the research of breast cancer .

HY-182747

HDAC6-IN-79	HDAC Autophagy Apoptosis	Cancer
HDAC6-IN-79 is a HDAC6 inhibitor with an IC₅₀ of 98.40 nM, and it also exhibits inhibitory activity against other HDAC subtypes (HDAC1: 639.0 nM, HDAC2: 798.9 nM, HDAC8: 865.7 nM, HDAC4: 1187 nM). HDAC6-IN-79 induces acetylation of α-tubulin and histone H3, reduces the viability of cancer cells, activates the autophagy pathway and induces apoptosis. HDAC6-IN-79 can be used for research related to urothelial carcinoma (bladder cancer) .

Cat. No.	Product Name	Target	Research Area

HY-P11770

α-Tubulin (residues 440–451)	Microtubule/Tubulin	Others
α-Tubulin (residues 440-451) (α-Tubulin Tail) is a Microtubule growth inhibitor. α-Tubulin (residues 440-451) transiently interacts with the longitudinal polymerization interface of *α-tubulin, regulating the apparent association and dissociation rates of tubulin* at the microtubule growing end. α-Tubulin (residues 440-451) inhibits microtubule growth .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W749442

7a-Hydroxyfrullanolide	Natural Products Sphaeranthus indicus L. Asteraceae Plants Source Classification	Microtubule/Tubulin
7a-Hydroxyfrullanolide has anticancer properties. 7a-Hydroxyfrullanolide reduces polymerization of α-, β-tubulin. 7a-Hydroxyfrullanolide preferrs to bind to β-tubulin over α-tubulin. 7a-Hydroxyfrullanolide also triggers DNA damage response arrests cells in the G2/M-phase. 7a-Hydroxyfrullanolide is an eudesmanolide sesquiterpene lactone (SL) and can be isolated from the flowering plants of the Asteraceae family .

Host:	Mouse (2) Rabbit (7)
Reactivity:	Human (9) Rat (6) Mouse (6) Monkey (2) Hamster (1)
Application:	IHC-P (6) ICC/IF (5) IP (3) IHC-F (1) WB (9) FC (2) ELISA (4)
Isotype:	IgG (6) IgG1 (2) IgG, Kappa (1)
Conjugation:	Non-conjugated (9)
Clonality:	Polyclonal (1) Monoclonal (5) Monoclonal Antibody (1) Recombinant (4)
Modification:	Phosphorylated (1) Acetylated (2) Lactylated (1) Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86200

	alpha Tubulin Antibody (YA5892) alpha tubulin	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	alpha Tubulin Antibody (YA5892) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to alpha Tubulin.

HY-P84435

	alpha Tubulin Antibody (YA4132) ALS22; TUBA1; H2-alpha; alpha-tubulin 1; TBA4A	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Monkey
	alpha Tubulin Antibody (YA4132) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to alpha Tubulin.

HY-P84435A

	alpha Tubulin Antibody (YA4132)(PBS only) ALS22; TUBA1; H2-alpha; alpha-tubulin 1; TBA4A	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Monkey
	alpha Tubulin Antibody (YA4132) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to alpha Tubulin.

HY-P83296

	*Phospho-alpha Tubulin* (Tyr272) Antibody (YA3041)** tubulin alpha-1B chain; alpha-tubulin ubiquitous; tubulin K-alpha-1; tubulin alpha-ubiquitous chain	WB, ICC/IF	Human
	Phospho-alpha Tubulin (Tyr272) Antibody (YA3041) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-alpha Tubulin (Tyr272).

HY-P83296A

	*Phospho-alpha Tubulin* (Tyr272) Antibody (YA3041)(PBS only)** tubulin alpha-1B chain; alpha-tubulin ubiquitous; tubulin K-alpha-1; tubulin alpha-ubiquitous chain	WB, ICC/IF	Human
	Phospho-alpha Tubulin (Tyr272) Antibody (YA3041) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-alpha Tubulin (Tyr272).

HY-P80485

	alpha Tubulin (acetyl K40) Antibody (YA626)	WB	Human
	alpha Tubulin (acetyl K40) Antibody (YA626) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to alpha Tubulin (acetyl K40).

HY-P87733

	*Acetyl-α Tubulin* (Lys40) Antibody (YA7418)**	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Acetyl-α Tubulin (Lys40) Antibody (YA7418) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Acetyl-α Tubulin (Lys40).

HY-P80538

	alpha Tubulin Antibody (YA625) ALS22; TUBA1; H2-alpha	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Hamster
	alpha Tubulin Antibody is a non-conjugated and Rabbit origined IgG monoclonal antibody, targeting to alpha Tubulin. It can be used as a loading control antibody.

HY-P810706

	*L-Lactyl-alpha Tubulin* (Lys40) Antibody** tubulin, alpha 1a, TUBA1	WB, IHC-P	Human, Mouse, Rat

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Cat. No.	Product Name		Classification

HY-151953

Antitubulin agent 1		Alkynes
Antitubulin agents-1 is an antitubulin agent that induces disruption of the microtubules (Microtubule/Tubulin) and increases *α-tubulin* acetylation. Antitubulin agents-1 has anticancer effects . Antitubulin agent 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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alpha-tubulin

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