2785404-83-1
Chemical Structure
PROTAC HDAC6 degrader 11
- CAS No.: 2785404-83-1
- Formula:C41H41F4N7O11
- Molecular Weight:883.80
IUPAC Name: 7-(4-(7-((3,5-dimethoxyphenyl)(2-(isopropylamino)ethyl)amino)quinoxalin-2-yl)-1H-pyrazol-1-yl)-N-hydroxyheptanamide
InChIKey: YHRIRNOBNMKZIJ-UHFFFAOYSA-N
SMILES: FC(F)(F)C(O)=O.O=C(CCCCCCCNC(COC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)=O)NC4=CC5=C(C=C4)N(C(C)=N5)CC6=C(C=C(C=C6)C(NO)=O)F
Biological Activity: PROTAC HDAC6 degrader 11 is a potent and selective HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with a DC50 value of 19.4 nM. PROTAC HDAC6 degrader 11 has IC50s of 4.54 nM and 0.647 μM for HDAC6 and HDAC1, respectively. PROTAC HDAC6 degrader 11 causes strong hyperacetylation of α-tubulin[1].
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PROTAC HDAC6 degrader 11 | 98.12% | PROTAC HDAC6 degrader 11 is a potent and selective HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with a DC50 value of 19.4 nM. PROTAC HDAC6 degrader 11 has IC50s of 4.54 nM and 0.647 μM for HDAC6 and HDAC1, respectively. PROTAC HDAC6 degrader 11 causes strong hyperacetylation of α-tubulin. | ||||||||||||||||||||
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Keywords
