83 Results for "

amyloid-beta 1-42

" in MedChemExpress (MCE) Product Catalog:
Products (83)

83 Results for "amyloid-beta 1-42" in MCE Product Catalog:

27
β-Amyloid (1-42), human
β-Amyloid (1-42), human
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27 Publications Verification
Cat. No.: HY-P1363A
CAS No.: 107761-42-2
Synonyms: amyloid β-peptide (1-42) (human)
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
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27
β-Amyloid (1-42), human TFA
β-Amyloid (1-42), human TFA
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27 Publications Verification
Cat. No.: HY-P1363
Synonyms: amyloid β-peptide (1-42) (human) TFA
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β-Amyloid (1-42) (Amyloid β-peptide (1-42), human TFA, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human TFA remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human TFA, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
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27
β-Amyloid (1-42), human, HFIP-treated
β-Amyloid (1-42), human, HFIP-treated
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27 Publications Verification
Cat. No.: HY-P1363B
CAS No.: 107761-42-2
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β-Amyloid (1-42), human, HFIP-treated, a 42-amino acid peptide that has been treated with HFIP from β-Amyloid (1-42), human (HY-P1363A), is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human, HFIP-treated remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, HFIP-treated, after being dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4°C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37°C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
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9
β-Amyloid (1-42), (rat/mouse)
β-Amyloid (1-42), (rat/mouse)
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9 Cited Publications
Cat. No.: HY-P1388
CAS No.: 166090-74-0
Synonyms: amyloid β-peptide (1-42) (rat/mouse)
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β-Amyloid (1-42), (rat/mouse) is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.
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9
β-Amyloid (1-42), (rat/mouse) TFA
β-Amyloid (1-42), (rat/mouse) TFA
0 Images
9 Cited Publications
Cat. No.: HY-P1388A
Synonyms: amyloid β-peptide (1-42) (rat/mouse) TFA
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β-Amyloid (1-42), (rat/mouse) TFA is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.
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4
Ethyl ferulate
Ethyl ferulate
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4 Cited Publications
Cat. No.: HY-N0061
CAS No.: 4046-02-0
Category:  

Monophenols Simple Phenylpropanols Phenols Dicerothamnus rhinocerotis Phenylpropanoids Plants Umbelliferae

Target:  

Reactive Oxygen Species (ROS)

Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress . Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity .
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2
Tofersen
Tofersen
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2 Cited Publications
Cat. No.: HY-132580
CAS No.: 2088232-70-4
Purity:  96.53%
Synonyms: BIIB067; ISIS-SOD1Rx; ISIS 333611
Target:  

SOD

Research Areas:  

Neurological Disease

Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
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2
Tofersen sodium
Tofersen sodium
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2 Cited Publications
Cat. No.: HY-132580A
CAS No.: 1898254-60-8
Purity:  97.19%
Synonyms: BIIB067 sodium; ISIS-SOD1Rx sodium; ISIS 333611 sodium
Target:  

SOD

Research Areas:  

Neurological Disease

Tofersen (BIIB067) sodium is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen sodium mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen sodium downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen sodium can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
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1
β-Amyloid (42-1), human
β-Amyloid (42-1), human
0 Images
1 Cited Publications
Cat. No.: HY-P1362
CAS No.: 317366-82-8
Synonyms: amyloid β Peptide (42-1)(human)
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β-Amyloid (42-1), human is the inactive form of Amyloid β Peptide (1-42). Its active form, β-Amyloid (1-42), may play a key role in the pathogenesis of Alzheimer's disease .
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1
5-FAM-β-Amyloid (1-42), human Tris
5-FAM-β-Amyloid (1-42), human Tris
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1 Cited Publications
Cat. No.: HY-P1363F3
Synonyms: 5-FAM-amyloid β-peptide (1-42) (human) Tris
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

5-FAM-β-Amyloid (1-42), human (5-FAM-Amyloid β-peptide (1-42) (human) Tris is a 5-FAM labeled β-Amyloid (1-42), human. β-Amyloid (1-42), human is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome.
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1
Homogentisic acid
Homogentisic acid
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1 Cited Publications
Cat. No.: HY-113283
CAS No.: 451-13-8
Purity:  99.46%
Category:  

Other disease Ketones, Aldehydes, Acids Disease markers Metabolic Disease Phenols Polyphenols Endogenous metabolite Disease Research Fields

Target:  

Amyloid-β Natriuretic Peptide Receptor (NPR) α-synuclein Transthyretin (TTR) Claudin

Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Accumulation of homogentisic acid downregulates tight junction proteins (such as claudin-5, occludin, ZO-1) and impairs blood-brain barrier integrity. Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as Aβ1-42, α-synuclein, SAA, Transthyretin (TTR), atrial natriuretic peptide), but also trigger oxidative stress, damage to the Wnt/β-catenin pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction. At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562). Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer .
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1
FITC-β-Ala-Amyloid β-Protein (1-42) ammonium
FITC-β-Ala-Amyloid β-Protein (1-42) ammonium
0 Images
1 Cited Publications
Cat. No.: HY-P3908
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

FITC-β-Ala-Amyloid β-Protein (1-42) ammonium is a FITC tagged Aβ1-42 peptide. Aβ1-42 plays a key role in the pathogenesis of Alzheimer’s disease .
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1
PQQ-trimethylester
PQQ-trimethylester
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1 Cited Publications
Cat. No.: HY-160831
CAS No.: 74447-88-4
Synonyms: PQQ-TME
Target:  

α-synuclein

Research Areas:  

Neurological Disease

PQQ-trimethylester (PQQ-TME) is a synthetic compound that is a trimethylester derivative of pyrroloquinoline quinone (PQQ). PQQ-trimethylester has twice the blood-brain barrier permeability of PQQ (HY-100196) in vitro. In addition, PQQ-trimethylester shows strong inhibitory activity against α-synuclein, amyloid β1-42 (Aβ1-42) and prion protein fibrillation. PQQ-trimethylester can be used in the study of neurodegenerative diseases .
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FITC-β-Ala-Amyloid β-Protein (1-42)
FITC-β-Ala-Amyloid β-Protein (1-42)
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Cat. No.: HY-P5096
CAS No.: 1802087-77-9
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

FITC-β-Ala-Amyloid β-Protein (1-42) is a FITC tagged Aβ1-42 peptide. Aβ1-42 plays a key role in the pathogenesis of Alzheimer’s disease .
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Biotin-β-Amyloid (1-42), human TFA
Biotin-β-Amyloid (1-42), human TFA
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Cat. No.: HY-P1363F1
Synonyms: Biotin-amyloid β-peptide (1-42) (human) TFA
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Biotin-β-Amyloid (1-42), human TFA (Biotin-Amyloid β-Peptide (1-42) (human) TFA) is the botin labeled β-Amyloid (1-42), human TFA (HY-P1363). β-Amyloid (1-42), human TFA is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease .
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Fustin
Fustin
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Cat. No.: HY-N8376
CAS No.: 20725-03-5
Synonyms: (±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone
Category:  

Flavanonols Flavonoids Phenols Polyphenols Plants Anacardiaceae Toxicodendron vernicifluum (Stokes) F. A. Barkl.

Target:  

Amyloid-β mAChR Cholinesterase (ChE)

Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research .
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Aducanumab (Mouse IgG2a)
Aducanumab (Mouse IgG2a)
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Cat. No.: HY-P990109

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Aducanumab (Mouse IgG2a) is a monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). The variable region of Aducanumab (Mouse IgG2a) is consistent with that of Aducanumab (HY-P9967), while the constant region is of Mouse IGG2a sequence. Aducanumab (Mouse IgG2a) has strong selectivity for Aβ fibrils with EC50s of >1 μM and 0.2 nM for monomeric Aβ1-40 and fibrillar Aβ1-42, respectively. Aducanumab (Mouse IgG2a) can be used for Alzheimer's disease (AD) research .
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β-Amyloid (1-38) TFA
β-Amyloid (1-38) TFA
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Cat. No.: HY-P3688A
Synonyms: Aβ (1-38) TFA; Aβ38 TFA
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β-Amyloid (1-38) (Aβ (1-38)) TFA is a β-Amyloid (Aβ) peptide. β-Amyloid (1-38) TFA interferes with the conversion of Aβ(1-42) to a β-sheet-rich aggregate. β-Amyloid (1-38)TFA reverses the negative impact of Aβ(1-42) on long-term potentiation in acute hippocampal slices and on membrane conductance in primary neurons, and mitigates an Aβ(1-42) phenotype in Caenorhabditis elegans .
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BF 227
BF 227
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Cat. No.: HY-105252A
CAS No.: 845647-80-5
Purity:  98.88%
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.
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β Amyloid (1-42) (scrambled) TFA
β Amyloid (1-42) (scrambled) TFA
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Cat. No.: HY-P4867A
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β Amyloid (1-42) (scrambled) TFA is a negative control of β-Amyloid (1-42), human TFA (HY-P1363) .
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