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antimitotic agent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) ADC Payload (2) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (6) Autophagy (4) c-Myc (1) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (6) Environmental Pollutants (1) Fungal (2) HIV (1) Microtubule/Tubulin (19) Mitosis (5) NF-κB (2) Reference Standards (4) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (29) Infection (2) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (2)
Click Chemistry:	ADC Synthesis (1) Azide (1)
Oligonucleotides:	Aptamers (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15575

VcMMAE Maximum Cited Publications 92 Publications Verification MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE; Vedotin	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).

HY-12053A

Vinorelbine ditartrate 20+ Cited Publications KW-2307; Nor-5'-anhydrovinblastine ditartrate	Microtubule/Tubulin Autophagy	Neurological Disease Cancer
Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC₅₀ of 1.25 nM.

HY-P990673

Vandortuzumab DSTP-3086S Antibody; RG-7450 Antibody	ADC Antibody Transmembrane Glycoprotein Mitosis	Cancer
Vandortuzumab (DSTP-3086S Antibody; RG-7450 Antibody) is a humanized anti-STEAP1 IgG1 antibody and antimitotic agent that can be conjugated with MMAE (HY-15162) to form the antibody-drug conjugate (ADC) Vandortuzumab vedotin. Vandortuzumab vedotin specifically binds to STEAP1 and drives internalization of the complex, releasing the MMAE (HY-15162) payload intracellularly. After binding to tubulin, MMAE inhibits cell division and induces cell death. Vandortuzumab exhibits antitumor activity in preclinical xenograft models of prostate cancer and can be used for research related to metastatic castration-resistant prostate cancer (mCRPC) .

HY-14621

Zingerone 5+ Cited Publications Vanillylacetone; Gingerone	Environmental Pollutants NF-κB	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties . Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways . Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells . Zingerone can cross the blood-brain barrier (BBB) .

HY-126681

SC-VC-PAB-MMAE 2 Publications Verification NHS-VC-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
SC-VC-PAB-MMAE (NHS-VC-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker SC-VC-PAB .

HY-W190943

Azido-PEG4-Val-Cit-PAB-MMAE 1 Publications Verification	Drug-Linker Conjugates for ADC	Cancer
Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH . Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-15575S

VcMMAE-d8 MC-Val-Cit-PAB-MMAE-d₈; mc-vc-PAB-MMAE-d₈	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) .

HY-12053

Vinorelbine KW-2307 base	Microtubule/Tubulin Autophagy	Cancer
Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC₅₀ of 1.25 nM.

HY-100566

SuO-Val-Cit-PAB-MMAE 3 Publications Verification	Drug-Linker Conjugates for ADC	Cancer
SuO-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the peptide SuO-Val-Cit-PAB .

HY-148870

Maytansinoid B	ADC Payload	Cancer
Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoid B can be used to conjugates with antibodies to form antibody-drug conjugates (ADCs). Maytansinoids are known as antimitotic agents, binding to tubulin and inhibiting microtubule assembly. Maytansinoids induces G2/M arrest in the cell cycle to induce apoptosis .

HY-P99705

Lifastuzumab vedotin RG-7599; DNIB-0600A; NaPi2b-ADC	Antibody-Drug Conjugates (ADCs)	Cancer
Lifastuzumab vedotin (RG-7599; DNIB0600A) is an antibody-drug conjugate (ADC) that comprises a humanized IgG1 anti-NaPi2b monoclonal antibody (MNIB2126A) and a potent antimitotic agent, monomethyl auristatin E (MMAE), which inhibits cell division by blocking the polymerization of tubulin. Lifastuzumab vedotin has the potential for non-small cell lung cancer (NSCLC) and platinum-resistant ovarian cancer (PROC) research .

HY-147006

Zovodotin MT-VC-ZD02044	Mitosis	Cancer
MT-VC-ZD02044 is a cytotoxic and anti-mitotic agent .

HY-103257

CHM-1 NSC656158	Microtubule/Tubulin	Cancer
CHM-1, a microtubule-destabilizing agent, inhibits tubulin polymerization. CHM-1 is a potent and selective antimitotic antitumor activity against human hepatocellular carcinoma. CHM-1 induces growth inhibition and apoptosis via G₂-M phase arrest in human hepatocellular carcinoma cells by activation of Cdc2 kinase activity .

HY-P1126

Dolastatin 15 DLS 15	Microtubule/Tubulin ADC Payload Apoptosis	Cancer
Dolastatin 15 (DLS 15), a depsipeptide derived from Dolabella auricularia, is a potent *antimitotic* agent structurally related to the antitubulin agent Dolastatin 10. Dolastatin 15 induces cell cycle arrest and apoptosis in multiple myeloma cells. Dolastatin 15 can be used as an ADC cytotoxin .

HY-N10958

Wikstrol A	Fungal HIV Microtubule/Tubulin	Infection
Wikstrol A is a potent antifungal, antimitotic and anti-HIV-1 Agent. Wikstrol A induces morphological deformation of P. oryzae mycelia with an MMDC value of 70.1 µM. Wikstrol A shows activity against microtubule polymerization with an IC₅₀ value of 131 µM. Wikstrol A shows anti-HIV-1 activity with an IC₅₀ value of 67.8 µM .

HY-12053AS

Vinorelbine-d3 ditartrate 2 Publications Verification KW-2307-d3 ditartrate; Nor-5'-anhydrovinblastine-d3 ditartrate	Microtubule/Tubulin Autophagy	Cancer
Vinorelbine-d₃ (ditartrate) is the deuterium labeled Vinorelbine ditartrate. Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

HY-101741

A-259745 A-289099	Microtubule/Tubulin Apoptosis	Cancer
A-259745 is an orally active antimitotic agent that binds to the colchicine-binding site of tubulin. A-259745 exhibits potent in vitro cytotoxic activity against both multi-drug-resistant and non-multi-drug-resistant cancer cell lines, with ED₅₀ values of 0.018 μM against HCT-15 and 0.028 μM against NCI-H460 cell lines. A-259745 inhibits tubulin polymerization, disrupts the dynamic equilibrium of the mitotic spindle, arrests dividing cells in metaphase, and subsequently induces apoptosis. A-259745 shows dose-dependent antitumor efficacy in murine tumor models. A-259745 can be used for the study of cancer .

HY-113722

DAT1	Microtubule/Tubulin	Cancer
DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization .

HY-177274

Antimitotic agent-2	Mitosis	Inflammation/Immunology
Antimitotic agent-2 (Compound 1) is an antimitotic agent. Antimitotic agent-2 inhibits the proliferation of human epidermal cells. Antimitotic agent-2 can be used in hyperproliferative skin disorders .

HY-125124

Chamaejasmenin D	Fungal	Infection
Chamaejasmenin D is an antimitotic and antifungal agent .

HY-W470415

Alfalone	Microtubule/Tubulin	Cancer
Alfalone (compound 9ia) is an antimitotic agent. Alfalone causes cleavage arrest and initiates the formation of tuberculate eggs .

HY-12053AR

Vinorelbine ditartrate (Standard) KW-2307 (Standard); Nor-5'-anhydrovinblastine ditartrate (Standard)	Reference Standards Microtubule/Tubulin Autophagy	Cancer
Vinorelbine (ditartrate) (Standard) is the analytical standard of Vinorelbine (ditartrate). This product is intended for research and analytical applications. Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC₅₀ of 1.25 nM.

HY-N6997

Ceratamine A	Microtubule/Tubulin	Cancer
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines .

HY-160702

DMBA-SIL-Mal-MMAE	Drug-Linker Conjugates for ADC	Cancer
DMBA-SIL-Mal-MMAE is a cytotoxin-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked DMBA-SIL-Mal .

HY-103711R

Estramustine (Standard)	Microtubule/Tubulin Reference Standards Apoptosis Mitosis	Cancer
Estramustine (Standard) is the analytical standard of Estramustine. This product is intended for research and analytical applications. Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts .

HY-14389

LP-261	Microtubule/Tubulin	Cancer
LP-261 is a potent and orally active **anti-mitotic agent** and shows an inhibition of in vitro tubulin polymerization with an EC₅₀ of 3.2 μM . LP-261 inhibits growth of a human non-small-cell lung tumor (NCI-H522) in vivo and can be used for cancer research .

HY-163523

PYRIB-SO 2	Microtubule/Tubulin	Cancer
PYRIB-SO 2 is a potent antimitotic agent. PYRIB-SO 2 shows antiproliferative activity and induces cell cycle arrest at G2/M phase. PYRIB-SO 2 reduces and disruptes microtubule structures. PYRIB-SO 2 binds to the colchicine-binding site (C-BS) of α, β-tubulin .

HY-161814

Apoptosis inducer 20	Apoptosis	Metabolic Disease
Apoptosis inducer 20 (12) causes G2/M cell cycle arrest and induction of apoptosis via caspase 3/7 activation, which occurred during M arrest. Apoptosis inducer 20 is a novel indolic benzenesulfonamide with anti-proliferative effect against a broad panel of cancer cell lines, which is proming for research of new anti-mitotic agents .

HY-14621R

Zingerone (Standard) Vanillylacetone (Standard); Gingerone (Standard)	Reference Standards NF-κB	Metabolic Disease Inflammation/Immunology Cancer
Zingerone (Standard) is the analytical standard of Zingerone. This product is intended for research and analytical applications. Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties . Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways . Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells .

HY-179525

DL78	c-Myc Microtubule/Tubulin Apoptosis	Cancer
DL78 is an effective anti-mitotic agent. DL78 induces mitotic arrest, mitotic catastrophe and apoptosis in cancer cells by disrupting the interaction between Myc and α-tubulin. DL78 exhibits broad anti-cancer activity, especially against cancer cells with chromosomal instability and excessive expression of MYC. DL78 significantly reduces tumor burden in the OV81.2 xenograft model. DL78 can be used for the study of ovarian cancer .

HY-156088

SSE1806	Apoptosis Microtubule/Tubulin Mitosis	Cancer
SSE1806 is a derivative of podophyllotoxin (a natural antimitotic agent) and a microtubule/tubulin inhibitor with significant anticancer and antiproliferative activities. The GI50 of SSE1806 on cancer cell growth ranges from 1.29-21.15 μM. SSE1806 causes mitotic abnormalities and G2/M phase arrest, increases p53 expression, and inhibits colon cancer organoid growth. SSE1806 is able to overcome multidrug resistance in cell lines overexpressing MDR-1 .

HY-182392

NFYi5	DNA/RNA Synthesis	Inflammation/Immunology
NFYi5 is a nuclear transcription factor-Y (NF-Y) inhibitor. NFYi5 disrupts the binding of NF-Y to DNA, accelerates the ubiquitin-independent degradation of the NF-YA subunit, and reduces the transcriptional activity of NF-Y. As an antimitotic agent, NFYi5 decreases the mRNA levels of NF-Y target genes without affecting the expression of housekeeping genes, and inhibits cell proliferation. NFYi5 can be used in the research of tissue fibrosis .

HY-103257R

CHM-1 (Standard) NSC656158 (Standard)	Reference Standards Microtubule/Tubulin	Cancer
CHM-1 (Standard) is the analytical standard of CHM-1 (HY-103257). This product is intended for research and analytical applications. CHM-1, a microtubule-destabilizing agent, inhibits tubulin polymerization. CHM-1 is a potent and selective antimitotic antitumor activity against human hepatocellular carcinoma. CHM-1 induces growth inhibition and apoptosis via G2-M phase arrest in human hepatocellular carcinoma cells by activation of Cdc2 kinase activity .

Cat. No.	Product Name	Target	Research Area

HY-P1126

Dolastatin 15 DLS 15	Microtubule/Tubulin ADC Payload Apoptosis	Cancer
Dolastatin 15 (DLS 15), a depsipeptide derived from Dolabella auricularia, is a potent *antimitotic* agent structurally related to the antitubulin agent Dolastatin 10. Dolastatin 15 induces cell cycle arrest and apoptosis in multiple myeloma cells. Dolastatin 15 can be used as an ADC cytotoxin .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990673

Vandortuzumab DSTP-3086S Antibody; RG-7450 Antibody	ADC Antibody Transmembrane Glycoprotein Mitosis	Cancer
Vandortuzumab (DSTP-3086S Antibody; RG-7450 Antibody) is a humanized anti-STEAP1 IgG1 antibody and antimitotic agent that can be conjugated with MMAE (HY-15162) to form the antibody-drug conjugate (ADC) Vandortuzumab vedotin. Vandortuzumab vedotin specifically binds to STEAP1 and drives internalization of the complex, releasing the MMAE (HY-15162) payload intracellularly. After binding to tubulin, MMAE inhibits cell division and induces cell death. Vandortuzumab exhibits antitumor activity in preclinical xenograft models of prostate cancer and can be used for research related to metastatic castration-resistant prostate cancer (mCRPC) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12053A

Vinorelbine ditartrate 20+ Cited Publications KW-2307; Nor-5'-anhydrovinblastine ditartrate	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Source Classification Cancer	Microtubule/Tubulin Autophagy
Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC₅₀ of 1.25 nM.

HY-14621

Zingerone 5+ Cited Publications Vanillylacetone; Gingerone	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Phenols Metabolic Disease Plants Inflammation/Immunology Disease Research Fields Source Classification Zingiberaceae	Environmental Pollutants NF-κB
Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties . Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways . Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells . Zingerone can cross the blood-brain barrier (BBB) .

HY-N10958

Wikstrol A	Flavonols Flavonoids Microorganisms Source Classification	Fungal HIV Microtubule/Tubulin
Wikstrol A is a potent antifungal, antimitotic and anti-HIV-1 Agent. Wikstrol A induces morphological deformation of P. oryzae mycelia with an MMDC value of 70.1 µM. Wikstrol A shows activity against microtubule polymerization with an IC₅₀ value of 131 µM. Wikstrol A shows anti-HIV-1 activity with an IC₅₀ value of 67.8 µM .

HY-125124

Chamaejasmenin D	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Biflavones Source Classification	Fungal
Chamaejasmenin D is an antimitotic and antifungal agent .

HY-12053AR

Vinorelbine ditartrate (Standard) KW-2307 (Standard); Nor-5'-anhydrovinblastine ditartrate (Standard)	Apocynaceae Alkaloids Structural Classification Plants Alkaloid Dimers Catharanthus roseus (L.) G. Don Source Classification	Reference Standards Microtubule/Tubulin Autophagy
Vinorelbine (ditartrate) (Standard) is the analytical standard of Vinorelbine (ditartrate). This product is intended for research and analytical applications. Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC₅₀ of 1.25 nM.

HY-N6997

Ceratamine A	Alkaloids Animals Classification of Application Fields Other Alkaloids Marine natural products Sponge Disease Research Fields Source Classification Cancer	Microtubule/Tubulin
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines .

HY-14621R

Zingerone (Standard) Vanillylacetone (Standard); Gingerone (Standard)	Zingiber officinale Roscoe Structural Classification Monophenols Microorganisms Ketones, Aldehydes, Acids Phenols Plants Source Classification Zingiberaceae	Reference Standards NF-κB
Zingerone (Standard) is the analytical standard of Zingerone. This product is intended for research and analytical applications. Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties . Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways . Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells .

Cat. No.	Product Name	Chemical Structure

HY-15575S

VcMMAE-d8
VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) .

HY-12053AS

Vinorelbine-d3 ditartrate 2 Publications Verification
Vinorelbine-d₃ (ditartrate) is the deuterium labeled Vinorelbine ditartrate. Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

Cat. No.	Product Name		Classification

HY-W190943

Azido-PEG4-Val-Cit-PAB-MMAE 1 Publications Verification		Azide ADC Synthesis
Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH . Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-177571

Sgc8c-M Sgc8c-VcMMAE		Aptamers
Sgc8c-M is a PTK7-targeted aptamer-drug conjugate (ApDC). Sgc8c-M is composed of the classic PTK7-specific aptamer Sgc8c, a cathepsin B (CTSB)-cleavable valine-citrulline (VC)-based linker, and the potent antimitotic agent Monomethyl auristatin E (MMAE) (HY-15162) as the payload. Sgc8c-M inhibits the growth of PTK7-overexpressing cancer cells. Sgc8c-M can be used for the study of PTK7-expressing advanced solid tumors .

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antimitotic agent

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Natural
Products