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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
capping domain
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "capping domain" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: 6-Methyladenosine (Standard); N-Methyladenosine (Standard)
Cat. No.: HY-177555
CAS No.: 2417851-90-0
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Research Areas:
AV5116 is a cap-dependent endonuclease inhibitor (CENI) that binds to the active site of the cap-dependent endonuclease (CEN) located in the N-terminal domain of the polymerase acidic. AV5116 exhibits potent inhibitory activity against influenza viruses (influenza A, B, and C viruses). AV5116 can be used for the study of influenza virus infections .
Cat. No.: HY-149263
CAS No.: 1422051-33-9
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HAA-09 is an orally active and potent anti-influenza agent, targeting the influenza PB2_cap binding domain. HAA-09 displays potent anti-influenza A virus activity, with an EC50 of 0.03 μM. HAA-09 shows polymerase inhibition, with an IC50 of 0.06±0.004 μM. HAA-09 blocks virus replication without causing obvious cytotoxicity .
Cat. No.: HY-134016B
CAS No.: 332153-24-9
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Ribavirin 5'-triphosphate ammonium is an inhibitor of the dengue virus NS5 2'-O-methyltransferase NS5 domain (NS5MTaseDV) (IC50 = 101 μM; Kd = 55 μM). Ribavirin 5'-triphosphate ammonium blocks RNA cap methylation by competitively binding to the GTP-binding site of NS5MTaseDV, thereby inhibiting the viral mRNA 2'-O-methyltransferase activity. Ribavirin 5'-triphosphate ammonium can be used for research on dengue fever .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
