20 Results for "

cardioprotective compound

" in MedChemExpress (MCE) Product Catalog:
Products (20)

20 Results for "cardioprotective compound" in MCE Product Catalog:

38
38 Publications Verification
Cat. No.: HY-N0055
CAS No.: 327-97-9
Synonyms: 3-O-Caffeoylquinic acid; Heriguard; NSC-407296
Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound .
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16
16 Cited Publications
Cat. No.: HY-N0527
CAS No.: 14937-32-7
Synonyms: Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose
Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloylglucose inhibits UBE2T-mediated p53 ubiquitination, upregulates p53, downregulates RRM1/RRM2 in pancreatic cancer organoids. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .
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9
9 Cited Publications
Cat. No.: HY-N0213
CAS No.: 18059-10-4
Synonyms: Verticinone; Raddeanine
Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .
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1
1 Cited Publications
Cat. No.: HY-N0559
CAS No.: 52659-56-0
Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a Kd value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis .
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1
1 Cited Publications
Cat. No.: HY-136203
CAS No.: 861446-16-4
Purity:  98.40%
Research Areas:  

Inflammation/Immunology Cancer

Resveratrol analog 1 is an analog of Resveratrol (HY-16561), compound 48. Resveratrol is a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.
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Cat. No.: HY-N0055R
CAS No.: 327-97-9
Synonyms: 3-O-Caffeoylquinic acid (Standard); Heriguard (Standard); NSC-407296 (Standard)
Chlorogenic acid (Standard) is the analytical standard of Chlorogenic acid. This product is intended for research and analytical applications. Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound .
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Cat. No.: HY-W001538
CAS No.: 3262-64-4
Synonyms: SPRC
Target:  

STAT MDM-2/p53

Research Areas:  

Inflammation/Immunology

S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H2S-releasing compound. S-Propargylcysteine reduces Ca 2+ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties .
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Cat. No.: HY-164853
CAS No.: 2228847-12-7
Kanglexin is an orally active and novel anthraquinone compound. Kanglexin inhibits NLRP3 inflammatory body activation and cell pyroptosis, and has a cardioprotective effect. Kanglexin promotes angiogenesis through FGFR1/ERK signaling pathway and accelerates diabetic wound healing. In addition, Kanglexin has the effect of lipid-lowering and inhibiting the dedifferentiation of vascular smooth muscle cells, and can be used in the study of hyperlipidemia, fatty liver and atherosclerosis .
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Cat. No.: HY-N0055S
Synonyms: 3-O-Caffeoylquinic acid-13C3; Heriguard-13C3; NSC-407296-13C3
Chlorogenic acid- 13C3 (Heriguard- 13C3; NSC-407296- 13C3) is 13C- and 15N-labeled Chlorogenic acid (HY-N0055). Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb.. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension .
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Cat. No.: HY-N0527R
CAS No.: 14937-32-7
Synonyms: Penta-O-galloyl-β-D-glucose (Standard); 1,2,3,4,6-Pentagalloyl glucose (Standard)
Pentagalloylglucose (Standard) is the analytical standard of Pentagalloylglucose. This product is intended for research and analytical applications. Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloylglucose inhibits UBE2T-mediated p53 ubiquitination, upregulates p53, downregulates RRM1/RRM2 in pancreatic cancer organoids. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .
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Cat. No.: HY-157448
CAS No.: 3028977-01-4
Target:  

Apoptosis

Research Areas:  

Cancer

CBR1-IN-6 (compound 1a) is a CBR1 inhibitor with chemosensitizing and cardioprotective activities .
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Cat. No.: HY-153020
CAS No.: 794582-71-1
Purity:  ≥98.0%
Research Areas:  

Cardiovascular Disease

HIF-PHD-IN-3 (compound 4) is a potent hiPSC-CM cardioprotective scaffold. HIF-PHD-IN-3 can induce upregulation of heme oxygenase-1 .
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Cat. No.: HY-N8754
CAS No.: 52811-31-1
(7S)-Dalbergiphenol is a cytotoxic compound that can be isolated from Brazilian red propoli. (7S)-Dalbergiphenol inhibits cancer cell viability. Brazilian red propoli has cardioprotective activity .
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Cat. No.: HY-163363
CAS No.: 2779507-62-7
Target:  

Adrenergic Receptor

Research Areas:  

Cancer

β-AR antagonist 2 (compound 43) is an antagonist of β-AR (IC50: 0.17 μM). β-AR-IN-1 inhibits the growth of mouse A549 xenograft tumors and shows cardioprotective efficacy against DOX-induced HF in C57 mice .
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Cat. No.: HY-N0213R
CAS No.: 18059-10-4
Synonyms: Verticinone (Standard); Raddeanine (Standard)
Peiminine (Standard) is the analytical standard of Peiminine. This product is intended for research and analytical applications. Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .
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Cat. No.: HY-159169
CAS No.: 3040383-48-7
Research Areas:  

Inflammation/Immunology

5-LOX/sEH-IN-1 (Compound 8o) is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC50 values of 3.05 μM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 (IC50=10.50 μM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects .
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Cat. No.: HY-116960
CAS No.: 113243-75-7
FR 76830 is a bradycardic agent with cardiomyocyte protective effects. FR 76830 attenuates the decrease in myocardial pH during the early stage of ischemia. FR 76830 improves ATP levels during the late stage of ischemia. FR 76830 reduces heart rate in a dose-dependent manner without decreasing the rate-pressure product of the myocardium. FR 76830 exerts cardioprotective effects during ischemia and reperfusion. FR 76830 can be used for the research of myocardial ischemia-reperfusion injury .
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Cat. No.: HY-N0559R
CAS No.: 52659-56-0
Kirenol (Standard) is the analytical standard of Kirenol (HY-N0559). This product is intended for research and analytical applications. Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a Kd value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis.
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Cat. No.: HY-N18732
CAS No.: 93456-04-3
Category:  

Extract

Target:  

Others

Terminalia arjuna extract is a natural compound derived from the Terminalia arjuna tree, rich in bioactive components such as triterpenoids, flavonoids, tannins, and polyphenols. Terminalia arjuna extract has cardioprotective effects, helping to strengthen the myocardium, lower cholesterol levels, stabilize blood pressure, and prevent thrombosis.
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Cat. No.: HY-N0345
CAS No.: 87480-46-4
Liriope muscari baily saponins C is one of major active compounds of L. muscari (Decne.) Baily. Liriope muscari baily saponins C possesses strong anti-inflammatory, immunopharmacological and cardioprotective activities. Liriope muscari baily saponins C has been studied as a candidate agent for cancer metastasis .
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