5-LOX/sEH-IN-1
5-LOX/sEH-IN-1 (Compound 8o) is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC50 values of 3.05 μM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 (IC50=10.50 μM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects.
For research use only. We do not sell to patients.
- CAS No.: 3040383-48-7
- Formula: C18H15N7O
- Molecular Weight:345.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 10.5 μM (COX-2)[1].
IC50: 2.20 nM (sEH)[1].
IC50: 3.05 μM (5-LOX)[1].
Chemical Information
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CAS No. 3040383-48-7
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Molecular Weight 345.36
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Formula C18H15N7O
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SMILES
N#CC1=C(N)N2C(NC1C3=CC=C(OC)C=C3)=NN=C2C4=CC=CN=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-LOX/sEH-IN-1 Related Classifications
HY-159169 Related Classifications
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