3 Results for "

cell-cycle redistribution

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "cell-cycle redistribution" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-N1073
CAS No.: 51225-30-0
Synonyms: 6-Isopentenylgenistein; Erythrinin B
Wighteone (6-Isopentenylgenistein; Erythrinin B) is a prenylated isoflavone that acts as a HSP90/EGFR L858R/T790M inhibitor and antifungal agent. Wighteone reduces the expression level of HSP90, blocks EGF-induced phosphorylation of EGFR, and thereby inhibits the downstream ERK and AKT signaling pathways. Wighteone induces cell cycle redistribution, inhibits proliferation and triggers apoptosis in cancer cells. Wighteone can be isolated from Erythrina suberosa, and can also be induced to synthesize in Lotus japonicus under specific conditions. Wighteone can be used to study HER2-positive breast cancer, leukemia, non-small cell lung cancer with EGFR L858R/T790M mutation, and fungal infections .
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Cat. No.: HY-189665
Research Areas:  

Cancer

YM17 is an orally active TNIK inhibitor with an IC50 of 181.9 nM and a Kd of 1.18 μM. YM17 induces Apoptosis and cell cycle redistribution. YM17 inhibits tumor growth in hepatocellular carcinoma xenograft models. YM17 can be used for research on hepatocellular carcinoma .
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Cat. No.: HY-181606
Research Areas:  

Neurological Disease Cancer

Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 is a dual MDM2 and α5β1 integrin modulator. Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 acts as an antiproliferative agent, apoptosis inducer and cell cycle regulator, induces reactivation of p53 and upregulation of p21, redistributes glioblastoma cells from the G0/G1 phase to the G2/M phase, and enhances apoptosis. Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 is applicable to the research of glioblastoma .
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