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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
conjugated estrogens
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "conjugated estrogens" in MCE Product Catalog:
1
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Cross-linked dextran G 25 is a cross-linked dextran gel chromatography medium that possesses multiple separation activities, including molecular sieve effects, weak anion exchange, and aromatic adsorption. Cross-linked dextran G 25 weakly exchanges cations through immobilized terminal carboxyl groups and repels anions at low ionic strength. Cross-linked dextran G 25 is used for the fractionation of low molecular weight solutes, including peptides, amino acids, nucleotide sugar derivatives, and aromatic compounds .
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1 Cited Publications
Cat. No.: HY-N7755
CAS No.: 14982-12-8
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Estradiol 3-glucuronide sodium is an estrogen metabolite, which is a glucuronide conjugate formed by the catalysis of uridine diphosphate glucuronosyltransferase in tissues such as the liver from Estradiol (HY-B0141). Estradiol 3-glucuronide sodium is a potent substrate of Mrp2, with an S50 of 55.7 μM. Estradiol 3-glucuronide sodium achieves hepatobiliary transport in hepatocytes through basolateral uptake via OATP1B1, OATP1B3 and OATP2B1, as well as apical efflux via MRP2 and BCRP .
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1 Cited Publications
Cat. No.: HY-W585842
CAS No.: 15270-30-1
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Estradiol 3-glucuronide is an estrogen metabolite, which is a glucuronide conjugate formed from Estradiol (HY-B0141) via catalysis by uridine diphosphate glucuronosyltransferases in tissues such as the liver. Estradiol 3-glucuronide is a potent substrate of Mrp2, with an S50 value of 55.7 μM. Estradiol 3-glucuronide achieves hepatobiliary transport in hepatocytes through basolateral uptake via OATP1B1, OATP1B3 and OATP2B1, as well as apical efflux via MRP2 and BCRP .
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MC-Val-Cit-PAB-PROTAC ERα Degrader-1 (compound LP2) consists an ADC linker and a PROTAC, whcih can be conjugated to an antibody to form PACs. MC-Val-Cit-PAB-PROTAC ERα Degrader-1 conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab) .
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Fulvestrant 3-β-D-Glucuronide, a metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer .
Synonyms: VH032-C5-NH2 dihydrochloride
Research Areas:
(S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader .
Cat. No.: HY-129619
CAS No.: 2222354-91-6
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SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation .
Cat. No.: HY-148140A
CAS No.: 9041-35-4
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Cross-linked dextran G 25, coarse is a cross-linked dextran gel chromatography coarse (average particle size D50 = 200-250 μm) that possesses multiple separation activities, including molecular sieve effects, weak anion exchange, and aromatic adsorption. Cross-linked dextran G 25, coarse weakly exchanges cations through immobilized terminal carboxyl groups and repels anions at low ionic strength. Cross-linked dextran G 25, coarse is used for the fractionation of low molecular weight solutes, including peptides, amino acids, nucleotide sugar derivatives, and aromatic compounds .
Cat. No.: HY-148140B
CAS No.: 9041-35-4
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Cross-linked dextran G 25, medium is a cross-linked dextran gel chromatography medium (average particle size D50 = 120-140 μm) that possesses multiple separation activities, including molecular sieve effects, weak anion exchange, and aromatic adsorption. Cross-linked dextran G 25, medium weakly exchanges cations through immobilized terminal carboxyl groups and repels anions at low ionic strength. Cross-linked dextran G 25, medium is used for the fractionation of low molecular weight solutes, including peptides, amino acids, nucleotide sugar derivatives, and aromatic compounds .
Cat. No.: HY-148140C
CAS No.: 9041-35-4
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Cross-linked dextran G 25, fine is a cross-linked dextran gel chromatography fine (average particle size D50 = 70-90 μm) that possesses multiple separation activities, including molecular sieve effects, weak anion exchange, and aromatic adsorption. Cross-linked dextran G 25, fine weakly exchanges cations through immobilized terminal carboxyl groups and repels anions at low ionic strength. Cross-linked dextran G 25, fine is used for the fractionation of low molecular weight solutes, including peptides, amino acids, nucleotide sugar derivatives, and aromatic compounds .
Cat. No.: HY-128527
CAS No.: 2158322-29-1
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PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab) .
Cat. No.: HY-128528
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PROTAC ER Degrader-2 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab) .
Cat. No.: HY-172067
CAS No.: 3026011-20-8
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ER ligand-9 is a conjugate of an estrogen receptor (Estrogen Receptor/ERR) and a linker, which can be used to synthesize PROTAC ERD-1233 (HY-169367) .
Cat. No.: HY-130499
Purity: 98.78%
Research Areas:
ERRα Ligand-Linker Conjugates 1 incorporates a ligand for estrogen-related receptor alpha (ERRα), and a PROTAC linker, which recruit E3 ligases MDM2. ERRα Ligand-Linker Conjugates 1 can be used in the synthesis of a series of PROTACs, such as PROTAC ERRalpha Degrader-1 (HY-128838). PROTAC ERRalpha Degrader-1 is an ERRα degrader .
Cat. No.: HY-136186
CAS No.: 2306389-04-6
Synonyms: VH032-C7-amine
Research Areas:
(S,R,S)-AHPC-C7-amine (VH032-C7-amine) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader .
Cat. No.: HY-136186B
CAS No.: 2502189-41-3
Synonyms: VH032-C7-amine hydrochloride
Research Areas:
(S,R,S)-AHPC-C7-amine (VH032-C7-amine) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader .
Cat. No.: HY-136187
CAS No.: 2170695-19-7
Synonyms: VH032-C5-NH2
Research Areas:
(S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader .
Cat. No.: HY-170332
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PROTAC ER Degrader-15 (Compound 40) is an orally active degrader of the estrogen receptor (ER) with anticancer activity，which can be used in breast cancer research (Pink: Target Protein Ligand (HY-170334); Black: Linker (HY-30756); Blue: E3 Ligase Ligand (HY-138793); E3 Ligase Ligand-Linker Conjugate (HY-169979)) .
Cat. No.: HY-136186A
CAS No.: 2415256-17-4
Synonyms: VH032-C7-amine dihydrochloride
Research Areas:
(S,R,S)-AHPC-C7-amine dihydrochloride is the dihydrochloride form of (S,R,S)-AHPC-C7-amine (HY-136186). (S,R,S)-AHPC-C7-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker. (S,R,S)-AHPC-C7-amine can be used for estrogen-related receptor α (ERRα) PROTAC degrader .
Cat. No.: HY-144314
CAS No.: 2906869-08-5
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PSDalpha is a photoactivatable PS-Degron targeting estrogen receptor α (ERα/ESR1), with a Ki of 72.8 nM for ERα. PSDalpha consists of an ERα-targeting estradiol moiety conjugated via an alkyne bond to triphenylamine-benzothiadiazole (TB), an aggregation-induced emission (AIE) photosensitizer. Upon visible light irradiation, PSDalpha generates singlet oxygen ( 1O2) and induces controllable ERα degradation. PSDalpha also induces G1 phase arrest and apoptosis. PSDalpha can be used in studies related to ERα-positive breast cancer and light-controlled targeted protein degradation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
