2906869-08-5
Chemical Structure
PSDalpha
- CAS No.: 2906869-08-5
- Formula:C44H39N3O2S
- Molecular Weight:673.86
IUPAC Name: 2-(2-(2-(2-(adamantan-1-yl)acetoxy)ethoxy)ethoxy)ethyl (S,2Z,4Z)-6-((3R,3aS,6aR,9aS,10aR,E)-6-formyl-9,10a-dimethyl-7-oxo-1,2,3,3a,4,6a,7,9a,10,10a-decahydrodicyclopenta[a,d][8]annulen-3-yl)hepta-2,4-dienoate
InChIKey: IUXDSWZYLRTQNC-QPSPDFFHSA-N
SMILES: C[C@@]12[C@](CC[C@]2(O)C#CC3=CC=C(C4=CC=C(C=C4)N(C5=CC=CC=C5)C6=CC=CC=C6)C7=NSN=C37)([H])[C@@]8([H])[C@@](CC1)([H])C9=CC=C(O)C=C9CC8
Biological Activity: PSDalpha is a photoactivatable PS-Degron targeting estrogen receptor α (ERα/ESR1), with a Ki of 72.8 nM for ERα. PSDalpha consists of an ERα-targeting estradiol moiety conjugated via an alkyne bond to triphenylamine-benzothiadiazole (TB), an aggregation-induced emission (AIE) photosensitizer. Upon visible light irradiation, PSDalpha generates singlet oxygen (1O2) and induces controllable ERα degradation. PSDalpha also induces G1 phase arrest and apoptosis. PSDalpha can be used in studies related to ERα-positive breast cancer and light-controlled targeted protein degradation[1].
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PSDalpha | PSDalpha is a photoactivatable PS-Degron targeting estrogen receptor α (ERα/ESR1), with a Ki of 72.8 nM for ERα. PSDalpha consists of an ERα-targeting estradiol moiety conjugated via an alkyne bond to triphenylamine-benzothiadiazole (TB), an aggregation-induced emission (AIE) photosensitizer. Upon visible light irradiation, PSDalpha generates singlet oxygen (1O2) and induces controllable ERα degradation. PSDalpha also induces G1 phase arrest and apoptosis. PSDalpha can be used in studies related to ERα-positive breast cancer and light-controlled targeted protein degradation. | |||||||||||||||||||||
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