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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
cyclic AMP phosphodiesterase
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "cyclic AMP phosphodiesterase" in MCE Product Catalog:
11
Target:
Research Areas:
Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .
Synonyms: 8-CPT-cAMP sodium; 8-(p-Chlorophenylthio)-cAMP sodium
Target:
Research Areas:
8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). 8-CPT-Cyclic AMP sodium is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM. 8-CPT-Cyclic AMP sodium also inhibits PDE III and PDE IV with IC50Cyclic AMP sodium is a very high affinity for Epac and is a potent Epac activator .
Cat. No.: HY-B0392
CAS No.: 85416-73-5
Synonyms: (+)-Rolipram; (S)-Rolipram
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Research Areas:
(S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells .
Research Areas:
Reproterol is a selective β2-adrenoceptor agonist and cAMP phosphodiesterase (PDE) inhibitor. Reproterol inhibits adenylate cyclase-induced phosphodiesterase activity. Reproterol inhibits histamine release from mast cells. Reproterol is applicable to research related to asthma .
Cat. No.: HY-N1289
CAS No.: 864719-17-5
Target:
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
3′,5′-Cyclic nucleotide phosphodiesterase is a hydrolytic enzyme that degrades cyclic 3', 5' -adenosine monophosphate (cyclic AMP). 3′,5′-Cyclic nucleotide phosphodiesterase is promising for research of cardiovascular diseases, inflammation, central nervous system disorders, and metabolic syndrome .
Cat. No.: HY-N8209
CAS No.: 88142-63-6
Category:
Eucommia ulmoides Oliver Lignans Eucommiaceae Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-W011293
CAS No.: 654-62-6
Synonyms: 2,4-Disulfamyl-5-trifluoromethylaniline
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Research Areas:
DTA (2,4-Disulfamyl-5-trifluoromethylaniline) is a cyclic AMP phosphodiesterase inhibitor that binds to erythrocyte carbonic anhydrase .
Cat. No.: HY-112631
CAS No.: 189362-27-4
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OPC-33540 is a highly selective and competitive PDE3 inhibitor with IC50 values of 0.32 nM (PDE3A) and 1.5 nM (PDE3B). OPC-33540 exhibits IC50s against PDE1, PDE2, PDE4, PDE5, and PDE7 of 42.9, 52.3, 100.8, 2.5, and 51.3 μM, respectively. OPC-33540 significantly enhances cAMP accumulation in platelets and effectively inhibits thrombin-induced platelet aggregation. OPC-33540 can be used in antithrombotic studies .
Cat. No.: HY-B0763R
CAS No.: 50847-11-5
Synonyms: KC-404 (Standard); AV-411 (Standard); MN-166 (Standard)
Research Areas:
Ibudilast (Standard) is the analytical standard of Ibudilast. This product is intended for research and analytical applications. Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .
Cat. No.: HY-E71643
Target:
Research Areas:
3',5'-Cyclic-AMP phosphodiesterase (EC 3.1.4.53) requires Mg2+ or Mn2+ for activity. 3',5'-Cyclic-AMP phosphodiesterase specifically hydrolyzes 3',5'-cAMP but does not hydrolyze other nucleoside 3',5'-cyclic phosphates, such as cGMP.
Cat. No.: HY-129665
CAS No.: 41498-37-7
Synonyms: (±)-O,O-Dimethylcoclaurine
Target:
Cat. No.: HY-U00136
CAS No.: 152633-54-0
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Research Areas:
Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively.
Cat. No.: HY-B1056R
CAS No.: 23249-97-0
Synonyms: Propazol (Standard); 2-Benzimidazolepropionic acid (Standard)
DTA (Standard) is the analytical standard of DTA. This product is intended for research and analytical applications. DTA (2,4-Disulfamyl-5-trifluoromethylaniline) is a cyclic AMP phosphodiesterase inhibitor that binds to erythrocyte carbonic anhydrase .
Cat. No.: HY-W011293R
CAS No.: 654-62-6
Synonyms: 2,4-Disulfamyl-5-trifluoromethylaniline (Standard)
Research Areas:
DTA (Standard) is the analytical standard of DTA. This product is intended for research and analytical applications. DTA (2,4-Disulfamyl-5-trifluoromethylaniline) is a cyclic AMP phosphodiesterase inhibitor that binds to erythrocyte carbonic anhydrase .
Cat. No.: HY-B0763S1
CAS No.: 2713301-45-0
Cat. No.: HY-167715
CAS No.: 58712-69-9
Research Areas:
Traxanox is an orally available diuretic that enhances phagocytosis of yeast granules by mouse peritoneal macrophages and rat peritoneal polymorphonuclear leukocytes in vitro.
Traxanox inhibits IgE-mediated histamine release and cyclic AMP phosphodiesterase
activity.Traxanox exhibits anti-inflammatory activity, as it inhibits the anaphylactoid reaction and reduces pleural fluid accumulation in experimental models of inflammation. Traxanox also demonstrates a synergistic effect when combined with hydrocortisone or indomethacin in suppressing adjuvant arthritis in rats.
Cat. No.: HY-B0763S
CAS No.: 102064-45-9
Cat. No.: HY-B0763S2
CAS No.: 1204192-90-4
Synonyms: KC-404-d7-1; AV-411-d7-1; MN-166-d7-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
