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diacylglycerol

" in MedChemExpress (MCE) Product Catalog:

190

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12

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31

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107613
    R 59-022
    2 Publications Verification

    DKGI-I; diacylglycerol kinase inhibitor I

    PKC 5-HT Receptor Inflammation/Immunology
    R 59-022 (DKGI-I) is a DGK inhibitor (IC50: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils .
    R 59-022
  • HY-108355
    R59949
    1 Publications Verification

    PKC Cancer
    R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol .
    R59949
  • HY-153343
    Veludacigib
    3 Publications Verification

    BAY 2965501

    DGK Cancer
    BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer .
    Veludacigib
  • HY-143212

    1-Stearoyl-2-docosahexaenoyl-sn-glycerol

    Ras p38 MAPK ERK PKC Metabolic Disease Inflammation/Immunology Cancer
    18:0-22:6 DG (1-Stearoyl-2-docosahexaenoyl-sn-glycerol) is a diacylglycerol (DG) that can interact with RasGRP (Ras guanine nucleotide-releasing protein) (Ki = 8.37 μM) and modulate the activation of MAP kinases (such as ERK1/ERK2), which play a crucial role in cellular signaling processes. 18:0-22:6 DG can also activate protein kinase C (PKC) isozyme. 18:0-22:6 DG can be used for research of cancer, immunology and metabolic disease .
    18:0-22:6 DG
  • HY-131897
    1-Stearoyl-2-arachidonoyl-sn-glycerol
    1 Publications Verification

    PKC TRP Channel Endogenous Metabolite Neurological Disease
    1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity .
    1-Stearoyl-2-arachidonoyl-sn-glycerol
  • HY-134200

    Endogenous Metabolite Others
    1-Palmitoyl-2-oleoyl-sn-glycerol is a diacylglycerol hormogonium inducer that can be isolated from the coralloid roots of Cycas revoluta. 1-Palmitoyl-2-oleoyl-sn-glycerol promotes the differentiation of filamentous Nostoc cell aggregates into motile hormogonia, and further induces the formation of dense bundle-like structures. 1-Palmitoyl-2-oleoyl-sn-glycerol is not only commonly used as a diacylglycerol standard, but also can effectively identify and separate glycerophosphate-containing phospholipid enantiomers after acetylation. 1-Palmitoyl-2-oleoyl-sn-glycerol is also used to study cyanobacterial developmental mechanisms and lipid analysis .
    1-Palmitoyl-2-oleoyl-sn-glycerol
  • HY-18540
    KT109
    1 Publications Verification

    MAGL DAGL Metabolic Disease Inflammation/Immunology
    KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC50 of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC50=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-Arachidonoylglycerol (HY-W011051), Arachidonic acid (HY-109590) and eicosanoids in mouse peritoneal macrophages .
    KT109
  • HY-149874
    BMS-502
    1 Publications Verification

    DGK Inflammation/Immunology Cancer
    BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research .
    BMS-502
  • HY-107416

    U-57908

    DAGL Acyltransferase mAChR COX Phospholipase Neurological Disease Metabolic Disease
    RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC50 of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC50 of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC) .
    RHC 80267
  • HY-50861
    AZD3988
    1 Publications Verification

    Acyltransferase Metabolic Disease
    AZD3988 is an orally active diacylglycerol acyl transferase-1 (DGAT-1) inhibitor. AZD3988 has excellent DGAT-1 (human) potency with an IC50 value of 0. 6 nM. AZD3988 can be used for the research of metabolic diseases such as diabetes, obesity .
    AZD3988
  • HY-12425
    DGAT1-IN-1
    2 Publications Verification

    Acyltransferase Metabolic Disease
    DGAT1-IN-1 is a diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor with a human IC50 of <10 nM and a mouse IC50 of <50 nM. DGAT1-IN-1 is applicable to the research of obesity-related diseases, type 2 diabetes and diabetes-related diseases .
    DGAT1-IN-1
  • HY-128468

    Liposome PKC Parasite Others
    1,2-Dimyristoyl-sn-glycerol is a saturated diacylglycerol and a weak second messenger for the activation of PKC .
    1,2-Dimyristoyl-sn-glycerol
  • HY-124314

    MAGL DAGL Metabolic Disease
    LEI-106 is a dual ABHD6 and DAGL-α inhibitor, with a Ki of 0.8 μM for ABHD6, and an IC50 of 18 nM and a Ki of 0.7 μM for DAGL-α. LEI-106 blocks the synthesis of 2-arachidonoylglycerol, reduces the level of endothelial cell-derived 2-arachidonoylglycerol, without altering the levels of cannabinoids and diacylglycerol. LEI-106 is applicable to research related to diet-induced obesity and metabolic syndrome .
    LEI-106
  • HY-153793

    DGKζ-IN-1

    DGK IFNAR Interleukin Related ERK Cancer
    Alcudacigib (ASP1570; DGKζ-IN-1) is an orally active diacylglycerol kinase ζ (DGKζ) inhibitor, with an IC50 of 4.7 nM against human DGKζ and an IC50 of 3.0 nM against mouse DGKζ. Alcudacigib selectively inhibits the kinase activity of DGKζ and induces proteasome-dependent degradation of DGKζ protein. Alcudacigib enhances the anti-tumor functions of T cells and NK cells. Alcudacigib can be used for the research of advanced/metastatic solid tumors .
    Alcudacigib
  • HY-W011311

    Drug Metabolite Others Cancer
    Eicosapentaenoic acid methyl ester is a degradant of a monogalactosyl diacylglycerol (an anticancer compound by inducing apoptosis) .
    Eicosapentaenoic acid methyl ester
  • HY-100960

    Ethylene glycol dicaprylate; Ethylene glycol dioctanoate; Ethylenedioctanoate

    DGK Cardiovascular Disease
    Dioctanoylglycol (Ethylene glycol dicaprylate), a diacylglycerol analog, is a diacylglycerol kinase (DGK) inhibitor (Ki of 58 μM) .
    Dioctanoylglycol
  • HY-18551

    DAGL Inflammation/Immunology
    DAGLβ-IN-1 is an inhibitor of diacylglycerol lipase-β (DAGLβ), serves as a versatile intermediate for the design of DAGL-tailored activity-based probes .
    DAGLβ-IN-1
  • HY-128465

    Endogenous Metabolite Others
    1,2-Dilauroyl-sn-glycerol is a saturated diacylglycerol and may play a role in second messenger signal transduction .
    1,2-Dilauroyl-sn-glycerol
  • HY-107613A
    R 59-022 hydrochloride
    2 Publications Verification

    DKGI-I hydrochloride; diacylglycerol kinase inhibitor I hydrochloride

    PKC 5-HT Receptor Infection Inflammation/Immunology Cancer
    R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC50: 2.8 µM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils .
    R 59-022 hydrochloride
  • HY-130791

    Drug Derivative Others
    Dioctanoin is a type of diacylglycerol .
    Dioctanoin
  • HY-N15895

    CDP-DAG ammonium; Dihexadecanoyl ammonium; Cytidine diacylglycerol ammonium

    Biochemical Assay Reagents Others
    16:0 CDP DG ammonium is a liponucleotide.
    16:0 CDP DG ammonium
  • HY-125319

    Acyltransferase Metabolic Disease
    Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity .
    Amidepsine A
  • HY-23199

    Acyltransferase Metabolic Disease
    H2-003 is a diacylglycerol acyltransferase DGAT2 inhibitor with an IC50 value of 7.4 μM against human targets. H2-003 reduces triacylglycerol biosynthesis and inhibits lipid droplet formation. H2-003 can be used in studies related to hepatic steatosis and insulin resistance .
    H2-003
  • HY-117168

    Endogenous Metabolite Metabolic Disease
    1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol (DAG) with linoleic acid (HY-N0729) (18:2) side chains attached at both the sn-1 and sn-2 positions . 1,2-Dilinoleoyl-sn-glycerol can be prepared from L-dilinoleoylphosphatidylcholine via hydrolysis with phospholipase C .
    1,2-Dilinoleoyl-sn-glycerol
  • HY-118442

    Tetradecasphing-4-enine

    PKC Cancer
    Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .
    Sphingosine (d14:1)
  • HY-158800

    Biochemical Assay Reagents Others
    1-NBD-decanoyl-2-decanoyl-sn-glycerol is a diacylglycerol (DAG) derivative, which is labeled with a fluorescent group NBD. 1-NBD-decanoyl-2-decanoyl-sn-glycerol is the substrate for diacylglycerol kinase (DGK), and can be used for quantitative detection of the DGF enzyme kinetics in vitro, and the changes in DAG and PA during cell signaling .
    1-NBD-decanoyl-2-decanoyl-sn-glycerol
  • HY-113400

    Cytidine diphosphate

    Endogenous Metabolite Others
    Cytidine 5'-diphosphate (Cytidine diphosphate) is a nucleoside diphosphate that acts as a carrier for phosphorylcholine, diacylglycerol, and other molecules during phospholipid synthesis .
    Cytidine 5'-diphosphate
  • HY-W051298

    Stearic diglyceride

    Biochemical Assay Reagents Metabolic Disease
    Distearin is a diacylglycerol containing stearic acid at two positions. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils .
    Distearin
  • HY-112851

    Acyltransferase Metabolic Disease
    Diacylglycerol acyltransferase inhibitor-1 is a diacylglycerol acyltransferase (DGAT1) inhibitor.
    Diacylglycerol acyltransferase inhibitor-1
  • HY-177601

    DGK Cancer
    DGK-IN-11 (Compound 1) is a diacylglycerol kinase (DGK) inhibitor. DGK-IN-11 exhibits inhibitory activity against DGKα and DGKγ. DGK-IN-11 regulates intracellular diacylglycerol levels and enhances T cell activation, cytokine production, and proliferation. DGK-IN-11 can be used for the study of cancer .
    DGK-IN-11
  • HY-N7399

    Environmental Pollutants Others
    Dipalmitin is an active product that can be extracted from root tuber of Typhonium giganteum Engl. Dipalmitin is a diacylglycerol that contains the saturated 16-carbon fatty acid Palmitic acid (HY-N0830) at two positions .
    Dipalmitin
  • HY-N9530

    Acyltransferase Angiotensin Receptor Bacterial Infection Cardiovascular Disease Metabolic Disease
    1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC50s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL .
    1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
  • HY-W583685

    Biochemical Assay Reagents Others
    1-Oleoyl-3-palmitoylglycerol is an isomerization byproduct in the preparation of diacylglycerol .
    1-Oleoyl-3-palmitoylglycerol
  • HY-169030

    Biochemical Assay Reagents Metabolic Disease
    Diarachidonin is a diacylglycerol that contains the ω-6 polyunsaturated 20-carbon fatty acid Arachidic acid (HY-W004260).
    Diarachidonin
  • HY-W008940

    Cytidine diphosphate disodium

    Endogenous Metabolite Metabolic Disease
    Cytidine 5'-diphosphate (Cytidine) disodium salt is a nucleoside diphosphate that acts as a carrier for phosphorylcholine, diacylglycerol, and other molecules during phospholipid synthesis .
    Cytidine 5'-diphosphate disodium salt
  • HY-W710399

    DG(16:0/0:0/18:0); 1-Palmitin-3-Stearin

    Endogenous Metabolite Metabolic Disease
    1-Palmitoyl-3-stearoyl-rac-glycerol is a diacylglycerol that contains palmitic acid (HY-N0830) at the sn-1 position and stearic acid (HY-B2219) at the sn-3 position. It has been found in palm-based diacylglycerols produced from palm stearin, palm mid fraction, palm oil, and palm olein, as well as in wheat bran and brewer’s spent grain extracts.
    2-Hydroxy-3-(palmitoyloxy)propyl stearate
  • HY-145624

    ION-769357

    Acyltransferase Metabolic Disease
    Obeversen is an antisense oligonucleotide that inhibits the synthesis of diacylglycerol acyltransferase 2 (DGAT-2). Obeversen can be used in the research of nonalcoholic fatty liver disease .
    Obeversen
  • HY-115769

    PKC Endocrinology
    1,2-Didecanoylglycerol, a synthetic diacylglycerol, is metabolized by platelets to 1,2-didecanoylphosphatidic acid (PA10) and activates protein kinase C (PKC) .
    1,2-Didecanoylglycerol
  • HY-168785

    Drug Derivative Others
    1,3-Dilinoelaidoyl glycerol is a diacylglycerol. 1,3-Dilinoelaidoyl glycerol contains Linoleic acid (HY-N0729) at sn-1 and sn-3 positions.
    1,3-Dilinoelaidoyl glycerol
  • HY-162854

    Acyltransferase Metabolic Disease
    Diacylglycerol acyltransferase inhibitor-2 (Example 8) is an inhibitor of Diacylglycerol Acyl Transferase 2 (DGAT2) with an IC50 value of 3.7 nM .
    Diacylglycerol acyltransferase inhibitor-2
  • HY-126599

    Luteoleersin

    DGK Cancer
    Cochlioquinone A is a ATP-competive diacylglycerol kinase inhibitor (Ki: 3.1 μM). Cochlioquinone A can be isolated from Drechslera sacchari .
    Cochlioquinone A
  • HY-N15782

    TRP Channel Neurological Disease
    18:0-PhoDAG is a photoswitchable diacylglycerol (DAG) that allows rapid photoactivation of these DAG-sensitive TRP channels .
    18:0-PhoDAG
  • HY-W336094

    1,3-Dilinolein

    Biochemical Assay Reagents Metabolic Disease
    1,3-Glyceryl dilinoleate (Compound 8, 1,3-Dilinolein) is an unsaturated diacylglycerol with Linoleic acid (HY-N0729) (18:2) side-chains attached at both the C-1 and C-3 positions, which can be used for lipid research .
    1,3-Glyceryl dilinoleate
  • HY-107613R

    DKGI-I (Standard); diacylglycerol kinase inhibitor I (Standard)

    PKC 5-HT Receptor Reference Standards Inflammation/Immunology
    R 59-022 (Standard) is the analytical standard of R 59-022. This product is intended for research and analytical applications. R 59-022 (DKGI-I) is a DGK inhibitor (IC50: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils .
    R 59-022 (Standard)
  • HY-N15340

    PKC Cancer
    1-Oleoyl-2-linoleoyl-sn-glycerol is a diacylglycerol (DG). 1-Oleoyl-2-linoleoyl-sn-glycerol can activate protein kinase C (PKC), thus triggering downstream signaling cascades and promoting tumor growth. 1-Oleoyl-2-linoleoyl-sn-glycerol is promising for research of breast cancer .
    1-Oleoyl-2-linoleoyl-sn-glycerol
  • HY-N15358

    Drug Metabolite Cardiovascular Disease Metabolic Disease
    15:0-18:1 DG is a type of diacylglycerol (DAG). 15:0-18:1 DG can be produced by hydrolysis of triacylglycerol (TAG) in butter fat. 15:0-18:1 DG is promising for research of obesity, cardiovascular diseases, and dietary interventions .
    15:0-18:1 DG
  • HY-105953

    ONO-995

    Prostaglandin Receptor Endocrinology
    Froxiprost (ONO-995) is a PGF2α (HY-12956) analogue. Froxiprost stimulates thymidine uptake, 1,2 diacylglycerol (1,2-DAG) accumulation, and phosphorylcholine formation in osteoblast-like MC3T3-E1 cells .
    Froxiprost
  • HY-165045

    DG(15:0/15:0/0:0); 1,2-Dipentadecanoin

    Endogenous Metabolite Others
    1,2-Dipentadecanoyl-rac-glycerol (DG(15:0/15:0/0:0)) is a compound mentioned in the study of the effects of insulin on 1,2-diacylglycerol in rat hearts. Insulin can increase the content of 1,2-diacylglycerol with a specific fatty acid composition in the heart, which may be related to cardiac contractility.
    1,2-Dipentadecanoyl-rac-glycerol
  • HY-N14793

    Acyltransferase Metabolic Disease
    Amidepsin B is a diacylglycerol acyltransferase (DGAT) inhibitor .
    Amidepsin B
  • HY-N14794

    Acyltransferase Metabolic Disease
    Amidepsin C is a diacylglycerol acyltransferase (DGAT) inhibitor .
    Amidepsin C

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