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Pathways Recommended:	Apoptosis

Results for "

early apoptosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (53) 11β-HSD (1) Akt (4) AMPK (1) Androgen Receptor (1) Autophagy (6) Bacterial (6) Bcl-2 Family (3) Biochemical Assay Reagents (1) c-Met/HGFR (1) c-Myc (2) Caspase (9) CDK (1) CMV (2) Complement System (1) CXCR (1) Cytochrome P450 (4) DNA/RNA Synthesis (4) Drug Intermediate (2) Drug Metabolite (3) EBV (1) EGFR (7) Endogenous Metabolite (3) Environmental Pollutants (1) ERK (4) FABP (1) FAK (2) Ferroptosis (1) Fluorescent Dye (6) Fungal (9) GLUT (1) HDAC (1) Histone Methyltransferase (1) HIV (2) HSP (1) HSV (3) IAP (1) IFNAR (1) Influenza Virus (3) Interleukin Related (5) Isotope-Labeled Compounds (3) JNK (3) MDM-2/p53 (2) MEK (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (5) MMP (2) Monoamine Oxidase (1) mTOR (2) N-myristoyltransferase (1) NF-κB (1) NOD-like Receptor (NLR) (2) p38 MAPK (2) PAK (1) Parasite (2) PARP (1) PD-1/PD-L1 (3) PERK (2) Photosensitizer (1) PI3K (6) Pim (1) PTEN (2) Pyroptosis (2) Pyruvate Kinase (1) Raf (2) Ras (1) Reactive Oxygen Species (ROS) (6) Reference Standards (11) SOD (2) SOS1 (1) STAT (1) Succinate Dehydrogenase (3) Thymidylate Synthase (1) TNF Receptor (5) Topoisomerase (4) Trk Receptor (1) TrxR (1) VEGFR (7) Virus Protease (1) Wee1 (1) YAP (2)
By Research Areas:	Cancer (51) Cardiovascular Disease (4) Endocrinology (1) Infection (17) Inflammation/Immunology (9) Metabolic Disease (5) Neurological Disease (10)
Oligonucleotides:	Aptamers (1)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Apoptosis Early 2 Factor (E2F) ASK1 SNIPERs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0146

Verteporfin Maximum Cited Publications 266 Publications Verification CL 318952	YAP Apoptosis Autophagy Photosensitizer	Cancer
Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell *apoptosis* . Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation .

HY-128868A

FITC-Dextran (MW 4000) Maximum Cited Publications 90 Publications Verification	Fluorescent Dye	Others
FITC-Dextran (MW 4000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of *apoptosis*. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .

HY-128868

FITC-Dextran (MW 10000) Maximum Cited Publications 90 Publications Verification	Fluorescent Dye	Others
FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of *apoptosis*. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .

HY-128868D

FITC-Dextran (MW 40000) 10+ Cited Publications	Fluorescent Dye	Others
FITC-Dextran (MW 40000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 40000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of *apoptosis*. FITC-Dextran (MW 40000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .

HY-128868B

FITC-Dextran (MW 3000-5000) 2 Publications Verification	Biochemical Assay Reagents	Others
FITC-Dextran (MW 3000-5000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 3000-5000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of *apoptosis*. FITC-Dextran (MW 3000-5000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption . Storage: protect from light.

HY-147308

Zelenirstat 2 Publications Verification PCLX-001	N-myristoyltransferase	Cancer
Zelenirstat is an orally acitve, small-molecule, dual N-myristoyltransferase (NMT) inhibitor, with IC₅₀s of 5 nM (NMT1) and 8 nM (NMT2), respectively. Zelenirstat can induce cell *apoptosis, has anti-cancer activity, inhibits early* B cell receptor (BCR) signaling, and can be used to study malignant lymphoma .

HY-119976

Boscalid 1 Publications Verification	Environmental Pollutants Apoptosis Fungal Mitochondrial Metabolism Succinate Dehydrogenase	Infection
Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces *apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS* accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .

HY-N1435

Oroxin B 5 Publications Verification	Apoptosis PI3K PTEN Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Oroxin B (OB) is a BBB-permeable flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early *apoptosis* rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT. Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells .

HY-147080

Avacincaptad pegol sodium ARC1905	Complement System	Others
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system .

HY-128868G

FITC-Dextran (MW 150000) 4 Publications Verification	Fluorescent Dye	Others
FITC-Dextran (MW 150000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=491 nm; Em=518 nm). FITC-Dextran (MW 150000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of *apoptosis*. FITC-Dextran (MW 150000) can be used in perfusion studies in animals or in fluorescence microlymphography, to study processes that affect the permeability of the blood brain barrier (BBB) . FITC-Dextran (MW 150000) can be used as fluorescent probe to study cell permeability .

HY-N6033

Ferruginol (+)-Ferruginol	EBV HSV Apoptosis	Infection Cardiovascular Disease Neurological Disease Cancer
Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of *Epstein-Barr virus early* antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis**. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities .

HY-138253

2′,2′-Difluorodeoxyuridine dFdU; 2',2'-Difluoro-2'-deoxyuridine	Drug Metabolite Apoptosis	Cancer
2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces *apoptosis* in cancer cells .

HY-P2310

Defensin HNP-1 human	Bacterial Parasite Apoptosis HIV HSV CMV TNF Receptor NOD-like Receptor (NLR) DNA/RNA Synthesis Influenza Virus	Cardiovascular Disease Infection
Defensin HNP-1 human is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human possesses immunomodulatory functions and can delay the *apoptosis* of neutrophils. Defensin HNP-1 human inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human has antileishmanial activity. Defensin HNP-1 human is involved in endothelial cell dysfunction during the early development of atherosclerosis .

HY-N0763

Angelicin Maximum Cited Publications 11 Publications Verification Isopsoralen	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase	Infection Inflammation/Immunology Cancer
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.

HY-115445

LCS-1 3 Publications Verification	Apoptosis SOD	Cancer
LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor. LCS-1 inhibits SOD1 activity with an IC₅₀ value of 1.07 μM. LCS-1 induces the early- and late-stage *apoptosis* of multiple myeloma (MM.1S) cells .

HY-N6746

Citrinin NSC 186	Bacterial Fungal Endogenous Metabolite Apoptosis	Infection Neurological Disease Cancer
Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-DY1016

FITC-Dextran (MW 10000) (solution)	Fluorescent Dye	Others
FITC-Dextran (MW 10000) (solution) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of *apoptosis*. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption . Solvent and Concentration: Sterile water: 2 mM

HY-101448

TMI-1 1 Publications Verification WAY-171318	MMP Apoptosis Interleukin Related TNF Receptor Caspase	Infection Neurological Disease Inflammation/Immunology Cancer
TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC₅₀ of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces *apoptosis* through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions .

HY-17587

4-Methylbenzylidene camphor 2 Publications Verification 4-MBC; Enzacamene	Apoptosis PI3K Akt ERK	Metabolic Disease
4-Methylbenzylidene camphor (4-MBC) is an endocrine disrupter that produces estrogen-like effects. 4-Methylbenzylidene camphor decreases the proliferation of human trophoblast cells and induces *apoptosis. 4-Methylbenzylidene camphor activates PI3K/AKT* and ERK1/2 signaling pathways and elevates intracellular ROS production. 4-Methylbenzylidene camphor is a ultraviolet (UV) filter and may hamper normal placental formation during early pregnancy .

HY-P2310A

Defensin HNP-1 human TFA	Bacterial Parasite Apoptosis HIV HSV CMV TNF Receptor Interleukin Related NOD-like Receptor (NLR) DNA/RNA Synthesis Influenza Virus	Cardiovascular Disease Infection
Defensin HNP-1 human TFA is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human TFA possesses immunomodulatory functions and can delay the *apoptosis* of neutrophils. Defensin HNP-1 human TFA inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human TFA has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human TFA has antileishmanial activity. Defensin HNP-1 human TFA is involved in endothelial cell dysfunction during the early development of atherosclerosis .

HY-N2445

Flavokawain C 4 Publications Verification	Apoptosis Akt JNK PERK Caspase PARP MDM-2/p53 IAP Reactive Oxygen Species (ROS) SOD FABP Autophagy AMPK mTOR GLUT EGFR PI3K HSP VEGFR FAK	Cancer
Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces *apoptosis. Flavokawain C downregulates FABP4, induces autophagy* in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer .

HY-101446

HIOC	Trk Receptor ERK Apoptosis	Neurological Disease
HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell *apoptosis. HIOC attenuates early* brain injury after SAH (subarachnoid hemorrhage). HIOC shows protective activity in an animal model for light-induced retinal degeneration .

HY-138253R

2′,2′-Difluorodeoxyuridine (Standard) dFdU (Standard); 2',2'-Difluoro-2'-deoxyuridine (Standard)	Drug Metabolite Reference Standards Apoptosis	Cancer
2′,2′-Difluorodeoxyuridine (Standard) is the analytical standard of 2′,2′-Difluorodeoxyuridine. This product is intended for research and analytical applications. 2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces *apoptosis* in cancer cells.

HY-138253S

2′,2′-Difluorodeoxyuridine-13C,15N2 dFdU-¹³C,¹⁵N₂; 2',2'-Difluoro-2'-deoxyuridine-¹³C,¹⁵N₂	Isotope-Labeled Compounds Drug Metabolite Apoptosis	Others
2′,2′-Difluorodeoxyuridine- ¹³C, ¹⁵N₂ (dFdU- ¹³C, ¹⁵N₂) is a ¹³C- and ¹⁵N-labeled compound. 2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces *apoptosis* in cancer cells .

HY-W017424

2-Aminobenzothiazole	Drug Intermediate Caspase Apoptosis	Neurological Disease Cancer
2-Aminobenzothiazole acts as a caspase 3/7 activator, an anticancer cytotoxic agent, and also exhibits neurotoxicity. 2-Aminobenzothiazole drives the apoptotic pathway by activating caspase 3/7, induces mitochondrial inner membrane depolarization, and triggers both early and late apoptosis via a caspase-dependent pathway. In zebrafish models, 2-Aminobenzothiazole induces oxidative damage in brain tissues and inhibits genes related to GABA and 5-HT synthesis pathways. Long-term exposure to 2-Aminobenzothiazole impairs motor ability, social behavior, anxiety-like state and cognitive function. 2-Aminobenzothiazole can be used in studies of human laryngeal carcinoma and related neurotoxicity .

HY-114520

TT01001	Monoamine Oxidase Mitochondrial Metabolism Apoptosis Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease
TT01001 is a selective and orally active mitoNEET agonist and a monoamine oxidase B (MAO-B) inhibitor (IC₅₀ = 8.84 μM). TT01001 does not activate PPARγ but interacts with MitoNEET. TT01001 attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction. TT01001 improves type II diabetes and ameliorates mitochondrial function of mice. TT01001 can used for the studies of type II diabetes and neurological disorders .

HY-W743654

Capsorubin	Apoptosis	Cancer
Capsorubin is a carotenoid found in peppers with multiple biological activities. Capsorubin (167 μM) inhibits lipid peroxidation induced by 2,2'-azobis(2,4-dimethylvaleronitrile) (AMVN) in vitro. Capsorubin (1 μM) reduces UVB-induced DNA strand breaks and apoptosis in human dermal fibroblasts. Capsorubin also inhibits Epstein-Barr virus early antigen (EBV-EA) activation induced by phorbol 12-myristate 13-acetate in Raji cells, a marker of tumorigenesis.

HY-P4846

Ac-Pro-Gly-Pro-OH 2 Publications Verification	CXCR Apoptosis IFNAR TNF Receptor Interleukin Related	Infection Inflammation/Immunology
Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and acts as a CXCR2 agonist . Ac-Pro-Gly-Pro-OH exerts bactericidal activity by generating hydrogen peroxide, inhibits pulmonary inflammation, and reduces immune cell apoptosis (apoptosis). Ac-Pro-Gly-Pro-OH promotes the production of IFN-γ and inhibits the production of TNF-α and IL-6 in leukocytes. Ac-Pro-Gly-Pro-OH increases the survival rate of mice in sepsis models, enhances the bactericidal activity of neutrophils, acts as a neutrophil chemoattractant, induces neutrophil polarization, and regulates inflammatory and repair processes. Ac-Pro-Gly-Pro-OH induces chronic inflammation and tissue remodeling through sustained action. Ac-Pro-Gly-Pro-OH is released via alkaline hydrolysis of corneal proteins in alkali-injured eyes, thereby driving the early infiltration of neutrophils into the cornea. Ac-Pro-Gly-Pro-OH is applicable to research related to sepsis, chronic obstructive pulmonary disease, cystic fibrosis, bronchiolitis obliterans syndrome, severe asthma, idiopathic pulmonary fibrosis, and corneal ulcer .

HY-155439

FAK-IN-14	FAK	Cancer
FAK-IN-14 (compound 8d) is a focal adhesion kinase(FAK) inhibitor with an IC₅₀ value of 0.2438 nM. FAK-IN-14 induces U87-MG cell early *apoptosis* and arrest the cell at the G2/M phase .

HY-138071

8α-Tigloyloxyhirsutinolide 13-O-acetate 8αTGH	STAT Pyroptosis Apoptosis Reactive Oxygen Species (ROS) c-Myc Bcl-2 Family TrxR	Cancer
8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, *apoptosis* in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo .

HY-DY1018

FITC-Dextran (MW 4000) (solution)	Fluorescent Dye	Others
FITC-Dextran (MW 4000) (solution) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of *apoptosis*. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption . Solvent and Concentration: Sterile water: 2 mM

HY-W743654R

Capsorubin (Standard)	Apoptosis Reference Standards	Cancer
Capsorubin (Standard) is the analytical standard of Capsorubin. This product is intended for research and analytical applications. Capsorubin is a carotenoid found in peppers with multiple biological activities. Capsorubin (167 μM) inhibits lipid peroxidation induced by 2,2'-azobis(2,4-dimethylvaleronitrile) (AMVN) in vitro. Capsorubin (1 μM) reduces UVB-induced DNA strand breaks and apoptosis in human dermal fibroblasts. Capsorubin also inhibits Epstein-Barr virus early antigen (EBV-EA) activation induced by phorbol 12-myristate 13-acetate in Raji cells, a marker of tumorigenesis.

HY-179152

Apoptosis inducer 54	Apoptosis Topoisomerase	Cancer
Apoptosis inducer 54 is an *apoptosis* inducer that interacts with topoisomerase II-DNA. Apoptosis inducer 54 induces cell cycle arrest at the S phase in cancer cells. Apoptosis inducer 54 significantly induces early and late apoptosis in A549 cells. Topoisomerase I-IN-20 can be used for the research of lung cancer and colon cancer .

HY-B0146R

Verteporfin (Standard) CL 318952 (Standard)	Reference Standards YAP Apoptosis Autophagy	Cancer
Verteporfin (Standard) is the analytical standard of Verteporfin. This product is intended for research and analytical applications. Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell *apoptosis* . Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation .

HY-162360

EGFR-IN-109	Apoptosis EGFR Caspase Bcl-2 Family	Cancer
EGFR-IN-109 (compound 4) is an EGFR inhibitor, with the IC₅₀ values of 25.8 and 182.3 nM for EGFR ^WT and EGFR ^T790M, respectively. EGFR-IN-109 arrests the cancer cells’ growth at the G2/M phase and induces both early and late apoptosis. EGFR-IN-109 can be used in cancer research .

HY-N1435R

Oroxin B (Standard)	Reference Standards Apoptosis PI3K PTEN Autophagy	Metabolic Disease Inflammation/Immunology Cancer
Oroxin B (Standard) is the analytical standard of Oroxin B. This product is intended for research and analytical applications. Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT . Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells .

HY-170577

PKM2-IN-8	Pyruvate Kinase Apoptosis	Cancer
PKM2-IN-8 (Compound 9b) is a pyruvate kinase M2 (PKM2) inhibitor (IC₅₀ = 0.31 μM). PKM2-IN-8 has potent antiproliferative activity against U87MG glioma cells. PKM2-IN-8 can induce early *apoptosis* and reduce lactate levels. PKM2-IN-8 can be used for the research of glioblastoma .

HY-178150

WEE1-IN-14	Wee1	Cancer
WEE1-IN-14 (Compound 14) is a selective WEE1 inhibitor (IC₅₀: 0.5 nM in L-RB-FEP calculations, 1.0 nM in ADP-Glo kinase assay). Inhibition of Wee1 in cancer cells disrupts the G2-M checkpoint, removes the regulatory controls on the cell cycle, and leads to early onset of mitotic failure followed by apoptosis of tumor cells. Therefore, WEE1-IN-14 is a useful tool for studying cancer biology .

HY-174908

SJL2-1	Histone Methyltransferase 11β-HSD Androgen Receptor	Cancer
SJL2-1 is a PRMT5 inhibitor, with an IC₅₀ of 1.56 μM. SJL2-1 suppresses proliferation, migration, and invasion in prostate cancer cells. SJL2-1 promotes apoptosis and blocks the cell cycle at the G0/G1 phase. SJL2-1 can target the binding of PRMT5 in cells and inhibit the methylation and expression of the androgen receptor. SJL2-1 can be used for the study of early androgen-sensitive prostate cancer and advanced castration-resistant prostate cancer (CRPC) .

HY-179098

Multi-target kinase-IN-8	Raf c-Met/HGFR Pim EGFR VEGFR Apoptosis	Cancer
Multi-target kinase-IN-8 (3d) is an anti-cancer agent. Multi-target kinase-IN-8 exhibits inhibitory activity against various protein kinases (B-Raf V600E (IC₅₀ = 0.078 µg/mL), c-Met (IC₅₀ = 0.405 µg/mL), Pim-1 (IC₅₀ = 1.053 µg/mL), EGFR WT (IC₅₀ = 0.177 µg/mL), VEGFR-2 (IC₅₀ = 0.275 µg/mL)). Multi-target kinase-IN-8 can induce cell cycle arrest and promote early and late *apoptosis*. Multi-target kinase-IN-8 is commonly used in cancer research .

HY-162826

Apoptosis inducer 27	Apoptosis	Cancer
Apoptosis inducer 27 (compound 1c) is a potent inhibitor of MDA-MB-231 breast cancer (IC₅₀: 12.8 μM) and can induce early apoptosis in breast cancer cells. Apoptosis inducer 27 can bind to DNA molecules, Bax and Bcl-2 proteins, and induce DNA damage .

HY-172961

EGFR-IN-162	EGFR	Cancer
EGFR-IN-162 (compound 20) is a potent EGFR inhibitor. EGFR-IN-162 increases early and late *apoptosis* and necrosis. EGFR-IN-162 is promising for research of breast cancer .

HY-161332

Antitumor agent-143	Ferroptosis Pyroptosis Apoptosis Reactive Oxygen Species (ROS)	Cancer
Antitumor agent-143 (compound 2c) is an antitumor agent that blocks cell proliferation of A549 cells during the S phase and induces an early *apoptosis. Antitumor agent-143 induces cell death via ferroptosis, apoptosis* by a ROS-mediated mitochondrial dysfunction pathway and GSDMD-mediated pyroptosis .

HY-157546

VEGFR-2-IN-40	VEGFR Interleukin Related Caspase	Inflammation/Immunology Cancer
VEGFR-2-IN-40 is a VEGFR-2 inhibitor. VEGFR-2-IN-40 boosts early and late *apoptosis. VEGFR-2-IN-40 decreases the levels immunomodulatory proteins TNF-α* and IL-6 while showing a four-fold rise in an apoptotic marker caspase-3 .

HY-151969

VEGFR-2-IN-30	VEGFR	Cancer
VEGFR-2-IN-30 is a VEGFR-2 inhibitor (IC₅₀: 66 nM). VEGFR-2-IN-30 also inhibits PDGFR, EGFR and FGFR1 with IC₅₀s of 180, 98, 82 nM respectively. VEGFR-2-IN-30 arrests cancer cell at S-phase and induces early and late apoptosis .

HY-176066A

c-Myc inhibitor 16 iodide	c-Myc Apoptosis	Cancer
c-Myc inhibitor 16 iodide (Compound W11) is a selective c-Myc G-quadruplex (c-Myc G4) inhibitor. c-Myc inhibitor 16 iodide inhibits the transcription and translation of the c-Myc gene, disrupts the tumor cell cycle, arrests cell growth in the G0/G1 phase and activates the mitochondrial apoptosis pathway to induce early *apoptosis* of cancer cells. c-Myc inhibitor 16 iodide is promising for research of breast cancer .

HY-172172

TS-IN-6	Thymidylate Synthase Apoptosis	Cancer
TS-IN-6 (Compound 10) is a thymidylate synthase (TS) inhibitor with an IC₅₀ value of 0.54 μM, demonstrating significant antiproliferative activity. TS-IN-6 induces G1 phase cell cycle arrest and *apoptosis* (marked by substantial increases in both early and late apoptotic rates) and shows potential for research on cancers such as colon, breast, and liver cancers .

HY-153685

NISC-6	Topoisomerase Akt Apoptosis	Cancer
NISC-6 is a novel dual Topo-IIα/Akt inhibitor. NISC-6 has inhibitory activity against various cells, such as UACC903 (IC₅₀ = 2.5 µM) and CHL-1 (IC₅₀ = 0.8 µM) cells. NISC-6 dose dependently induces early and late *apoptosis*. NISC-6 can be used for research on melanoma .

HY-161153

Microtubule inhibitor 9	Apoptosis	Cancer
Microtubule inhibitor 9 (Compound O-7) is a 2-Aryl-1H-benzo [d] imidazole derivative with in vitro anticancer activity. Microtubule inhibitor 9 can induce cell cycle arrest at the G2/M phase and early *apoptosis*. Microtubule inhibitor 9 inhibits cancer cell migration by inhibiting wound healing and colony formation .

HY-173164

EGFR/BRAFV600E-IN-4	EGFR Raf Apoptosis	Cancer
EGFR/BRAFV600E-IN-4 (Compound 10f) is a dual EGFR and BRAF ^V600E inhibitor with IC₅₀ values of 61 nM and 43 nM, respectively. EGFR/BRAFV600E-IN-4 arrests cell cycle, induces *apoptosis* in both early and late stages and inhibits cancer cells growth in vitro, and has a broad anticancer activity .

Cat. No.	Product Name	Type

HY-128868A

FITC-Dextran (MW 4000)

Maximum Cited Publications

90 Publications Verification

Fluorescent Dyes

FITC-Dextran (MW 4000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .

HY-128868

FITC-Dextran (MW 10000)

Maximum Cited Publications

90 Publications Verification

Fluorescent Dyes

FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .

HY-128868D

FITC-Dextran (MW 40000)

10+ Cited Publications

Fluorescent Dyes

FITC-Dextran (MW 40000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 40000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 40000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .

HY-128868B

FITC-Dextran (MW 3000-5000)

2 Publications Verification

Fluorescent Dyes

FITC-Dextran (MW 3000-5000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 3000-5000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 3000-5000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption . Storage: protect from light.

HY-128868G

FITC-Dextran (MW 150000)

4 Publications Verification

Fluorescent Dyes

FITC-Dextran (MW 150000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=491 nm; Em=518 nm). FITC-Dextran (MW 150000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 150000) can be used in perfusion studies in animals or in fluorescence microlymphography, to study processes that affect the permeability of the blood brain barrier (BBB) . FITC-Dextran (MW 150000) can be used as fluorescent probe to study cell permeability .

HY-DY1016

FITC-Dextran (MW 10000) (solution)

Fluorescent Dyes

FITC-Dextran (MW 10000) (solution) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .
Solvent and Concentration: Sterile water: 2 mM

HY-DY1018

FITC-Dextran (MW 4000) (solution)

Fluorescent Dyes

FITC-Dextran (MW 4000) (solution) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .
Solvent and Concentration: Sterile water: 2 mM

Cat. No.	Product Name	Type

HY-119976

Boscalid

1 Publications Verification

Biochemical Assay Reagents

Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .

HY-119976R

Boscalid (Standard)

Biochemical Assay Reagents

Boscalid (Standard) is the analytical standard of Boscalid. This product is intended for research and analytical applications. Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .

Cat. No.	Product Name	Target	Research Area

HY-P2310

Defensin HNP-1 human	Bacterial Parasite Apoptosis HIV HSV CMV TNF Receptor NOD-like Receptor (NLR) DNA/RNA Synthesis Influenza Virus	Cardiovascular Disease Infection
Defensin HNP-1 human is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human possesses immunomodulatory functions and can delay the *apoptosis* of neutrophils. Defensin HNP-1 human inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human has antileishmanial activity. Defensin HNP-1 human is involved in endothelial cell dysfunction during the early development of atherosclerosis .

HY-P2310A

Defensin HNP-1 human TFA	Bacterial Parasite Apoptosis HIV HSV CMV TNF Receptor Interleukin Related NOD-like Receptor (NLR) DNA/RNA Synthesis Influenza Virus	Cardiovascular Disease Infection
Defensin HNP-1 human TFA is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human TFA possesses immunomodulatory functions and can delay the *apoptosis* of neutrophils. Defensin HNP-1 human TFA inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human TFA has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human TFA has antileishmanial activity. Defensin HNP-1 human TFA is involved in endothelial cell dysfunction during the early development of atherosclerosis .

HY-P4846

Ac-Pro-Gly-Pro-OH 2 Publications Verification	CXCR Apoptosis IFNAR TNF Receptor Interleukin Related	Infection Inflammation/Immunology
Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and acts as a CXCR2 agonist . Ac-Pro-Gly-Pro-OH exerts bactericidal activity by generating hydrogen peroxide, inhibits pulmonary inflammation, and reduces immune cell apoptosis (apoptosis). Ac-Pro-Gly-Pro-OH promotes the production of IFN-γ and inhibits the production of TNF-α and IL-6 in leukocytes. Ac-Pro-Gly-Pro-OH increases the survival rate of mice in sepsis models, enhances the bactericidal activity of neutrophils, acts as a neutrophil chemoattractant, induces neutrophil polarization, and regulates inflammatory and repair processes. Ac-Pro-Gly-Pro-OH induces chronic inflammation and tissue remodeling through sustained action. Ac-Pro-Gly-Pro-OH is released via alkaline hydrolysis of corneal proteins in alkali-injured eyes, thereby driving the early infiltration of neutrophils into the cornea. Ac-Pro-Gly-Pro-OH is applicable to research related to sepsis, chronic obstructive pulmonary disease, cystic fibrosis, bronchiolitis obliterans syndrome, severe asthma, idiopathic pulmonary fibrosis, and corneal ulcer .

Cat. No.	Product Name

HY-K1096

Annexin V-FITC/7-AAD Apoptosis Detection Kit
MCE Annexin V-FITC/7-AAD Apoptosis Detection Kit can be utilized to detect the occurrence of early apoptosis.

HY-K1073

Annexin V-FITC/PI Apoptosis Detection Kit Maximum Cited Publications 66 Publications Verification
MCE Annexin V-FITC/PI Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence (Annexin V-/PI-), early apoptosis cells show green fluorescence(Annexin V+/PI-), late apoptosis cells and necrosis cells show red and green fluorescence (Annexin V+/PI+).

HY-K1080

Annexin V-iFluor 488/PI Apoptosis Detection Kit 1 Publications Verification
MCE Annexin V-iFluor 488/PI Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence (Annexin V-/PI-),, early apoptosis cells show green fluorescence (Annexin V+/PI-), late apoptosis cells and necrosis cells show red and green fluorescence (Annexin V+/PI+).

HY-K1077

Annexin V-mCherry/SYTOX Green Apoptosis Detection Kit 2 Publications Verification
Annexin V-mCherry/SYTOX Green Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence, apoptosis cells show red fluorescence, necrosis cells show red and green fluorescence.

HY-K1076

Annexin V-mCherry Apoptosis Detection Kit
Annexin V-mCherry Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence, apoptosis cells and necrosis cells show red fluorescence.

HY-K1075

Annexin V-PE Apoptosis Detection Kit 1 Publications Verification
MCE Annexin V-PE Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence, apoptosis cells and necrosis cells show red fluorescence.

HY-K1093

VF 647A-Annexin V/PI Apoptosis Detection Kit 1 Publications Verification
MCE VF 647A-Annexin V/PI Apoptosis Detection Kit can be utilized to detect the level of cell apoptosis.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1435

Oroxin B 5 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Phenols Polyphenols Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields Source Classification Cancer	Apoptosis PI3K PTEN Autophagy
Oroxin B (OB) is a BBB-permeable flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early *apoptosis* rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT. Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells .

HY-N6033

Ferruginol (+)-Ferruginol	Cupressaceae Terpenoids Diterpenoids Thuja standishii (Gord.) Carr. Plants	EBV HSV Apoptosis
Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of *Epstein-Barr virus early* antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis**. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities .

HY-N0763

Angelicin Maximum Cited Publications 11 Publications Verification Isopsoralen	Classification of Application Fields Leguminosae Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Source Classification Cancer	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.

HY-N6746

Citrinin NSC 186	Infection Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Bacterial Fungal Endogenous Metabolite Apoptosis
Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-N2445

Flavokawain C 4 Publications Verification	Structural Classification Classification of Application Fields Piperaceae Plants Chalcones Flavonoids other families Phenols Polyphenols Piper methysticum G.Forst. Disease Research Fields Source Classification Cancer	Apoptosis Akt JNK PERK Caspase PARP MDM-2/p53 IAP Reactive Oxygen Species (ROS) SOD FABP Autophagy AMPK mTOR GLUT EGFR PI3K HSP VEGFR FAK
Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces *apoptosis. Flavokawain C downregulates FABP4, induces autophagy* in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer .

HY-138071

8α-Tigloyloxyhirsutinolide 13-O-acetate 8αTGH	Terpenoids Sesquiterpenes Plants Compositae Dalbergia frutescens (Vell.) Britton Source Classification	STAT Pyroptosis Apoptosis Reactive Oxygen Species (ROS) c-Myc Bcl-2 Family TrxR
8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, *apoptosis* in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo .

HY-N1435R

Oroxin B (Standard)	Structural Classification Flavonoids Flavones Phenols Polyphenols Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Source Classification	Reference Standards Apoptosis PI3K PTEN Autophagy
Oroxin B (Standard) is the analytical standard of Oroxin B. This product is intended for research and analytical applications. Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT . Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells .

HY-W005255R

3-(3-Hydroxyphenyl)propionic acid (Standard)	Structural Classification Monophenols Microorganisms Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Citrinin (Standard) is the analytical standard of Citrinin. This product is intended for research and analytical applications. Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-N6746R

Citrinin (Standard) NSC 186 (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Bacterial Fungal Endogenous Metabolite Apoptosis
Citrinin (Standard) is the analytical standard of Citrinin. This product is intended for research and analytical applications. Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-N8321R

5-O-Caffeoylshikimic acid (Standard)	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Phenols Polyphenols Plants Source Classification	Reference Standards Others
Insect repellent M 3535 (Standard) is the analytical standard of Insect repellent M 3535. This product is intended for research and analytical applications. Insect repellent M 3535 (Ethyl butylacetylaminopropionate; IR-3535) is a novel potent anthelmintic that is toxic to zebrafish with a lethal concentration 50 (LC50) of 140 mg/L at 72 hours post fertilization (hpf). Insect repellent M 3535 causes morphological abnormalities and cardiac defects in early embryonic development of zebrafish by potentially inducing the production and accumulation of reactive oxygen species (Reactive Oxygen Species) and activating oxidative stress responses, thereby activating the endogenous apoptosis pathway .

HY-N17440

2-Methoxyjuglone	Quinones Structural Classification Juglandaceae Phenols Plants Naphthalene Quinones Juglans mandshurica Source Classification	Apoptosis Caspase Bcl-2 Family DNA/RNA Synthesis Bacterial Fungal
2-Methoxyjuglone, a naphthoquinone, is an *apoptosis* inducer. 2-Methoxyjuglone activates caspase-9 and caspase-3 via the mitochondrial cytochrome c-dependent intrinsic apoptosis cascade. 2-Methoxyjuglone increases pro-apoptotic Bax levels, decreases anti-apoptotic Bcl-2 levels, and promotes mitochondrial cytochrome c release. 2-Methoxyjuglone induces apoptosis morphological features, early apoptosis, S-phase and G₂/M-phase cell cycle arrest, and DNA double-strand breaks. 2-Methoxyjuglone exerts activity against Gram-positive bacteria, pathogenic fungi, and phytopathogenic fungi. 2-Methoxyjuglone can be used for the research of hepatocellular carcinoma, osteosarcoma, colon adenocarcinoma, breast cancer, fungal infection, bacterial infection .

HY-N18470

Gadusol	Structural Classification Natural Products Animals Source Classification	DNA/RNA Synthesis Apoptosis Reactive Oxygen Species (ROS)
Gadusol is a potent, maternally supplied natural sunscreen. Gadusol is synthesized by the mother during oogenesis and stored in eggs, representing the primary sunscreen mechanism during the early developmental stages of fish. Gadusol directly prevents UVB-induced DNA damage and reduces the generation of ROS thereby avoiding cellular stress and *apoptosis*. Gadusol does not exert antioxidant functions in zebrafish embryos. Gadusol can be used in studies related to topical photoprotective cosmetics .

Cat. No.	Product Name	Chemical Structure

HY-138253S

2′,2′-Difluorodeoxyuridine-13C,15N2

2′,2′-Difluorodeoxyuridine- ¹³C, ¹⁵N₂ (dFdU- ¹³C, ¹⁵N₂) is a ¹³C- and ¹⁵N-labeled compound. 2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces apoptosis in cancer cells .

HY-119976S

Boscalid-d4

Boscalid-d₄ is the deuterium labeled Boscalid. Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis .

HY-N6746S1

Citrinin-13C13

Citrinin- ¹³C₁₃ (NSC 186- ¹³C₁₃) is the ¹³C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

Cat. No.	Product Name		Classification

HY-147080

Avacincaptad pegol sodium ARC1905		Aptamers
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system .

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