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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
frameshift mutation
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "frameshift mutation" in MCE Product Catalog:
Cat. No.: HY-159641
CAS No.: 3034880-93-5
Synonyms: BAY-3605349
Target:
Research Areas:
VVD-130037 (BAY-3605349) is a covalent molecular glue and allosteric NRF2 degrader. VVD-130037 covalently binds to KEAP1 and allosterically enhances the affinity of KEAP1-CUL3, promotes the formation of the active KEAP1-CUL3 E3 ligase complex, and thereby enhances the ubiquitination and degradation of NRF2. VVD-130037 exhibits KEAP1 target-binding activity both in in vitro systems and mouse models, and it can be used in research related to NRF2-dependent cancers, solid tumors harboring KEAP1 nonsense mutations and frameshift mutations, as well as advanced solid tumors .
Target:
Research Areas:
Quindoxin is an antibacterial and growth promoter, commonly used in the livestock industry. Quindoxin exhibits clear dose-dependent mutagenic activity against Salmonella typhimurium TA98 and TA100 strains. Quindoxin can cause DNA damage and has potential genotoxicity and carcinogenic risks .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
