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glucose amylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GLUT (2) Amylases (12) Biochemical Assay Reagents (3) Dipeptidyl Peptidase (2) Endogenous Metabolite (4) Environmental Pollutants (1) Glycosidase (6) NF-κB (2) Phosphatase (2) PPAR (1) Reference Standards (2)
By Research Areas:	Cancer (2) Endocrinology (1) Inflammation/Immunology (4) Metabolic Disease (20)

Inhibitors & Agonists

Natural
Products

Targets Recommended: GLUT Glucose-6-Phosphate Isomerase (GPI) SGLT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1425

Tiliroside 3 Publications Verification	Others	Metabolic Disease
Tiliroside, a glycosidic flavonoid, possesses anti-diabetic activities. Tiliroside is a noncompetitive inhibitor of *α-amylase* with a K_i value of 84.2 μM. Tiliroside inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract .

HY-B2193

α-Amylase 2 Publications Verification	Environmental Pollutants Amylases	Others
α-Amylase is a hydrolase enzyme that catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose.

HY-N0668

Rubusoside 2 Publications Verification	GLUT Amylases NF-κB	Metabolic Disease Inflammation/Immunology Cancer
Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits NF-κB and α-amylase (α-amylase) .

HY-P2968

Bacterial α-Amylase	Amylases	Others
Bacterial α-Amylase catalyses the hydrolysis of internal α-1,4-glycosidic linkages in starch in low molecular weight products, such glucose, maltose and maltotriose units. Bacterial α-Amylase is often used in biochemical studies .

HY-B2193A

α-Amylase, Human Saliva 1,4-alpha-D-Glucan-glucanohydrolase, ptyalin	Biochemical Assay Reagents	Metabolic Disease Inflammation/Immunology
α-Amylase, Human Saliva (1,4-alpha-D-Glucan-glucanohydrolase) is a hydrolase enzyme that can be isolated from human saliva. α-Amylase, Human Saliva catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose. α-Amylase, Human Saliva can be used in life science research .

HY-B2193C

α-Amylase, Porcine Pancreatic 1,4-alpha-D-Glucan-glucanohydrolase, amy2, PPA, PA	Biochemical Assay Reagents	Others
α-Amylase, Porcine Pancreatic (1,4-alpha-D-Glucan-glucanohydrolase) is a hydrolase enzyme that can be isolated from porcine pancreatic. α-Amylase, Porcine Pancreatic catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose. α-Amylase, Porcine Pancreatic can be used in life science research .

HY-B2193B

α-Amylase, Human Pancreas amylase, a-amylase, 1,4-a-D-glucan glucanohydrolase, glycogenase	Biochemical Assay Reagents	Others
α-Amylase, Human Pancreas (Amylase) is a hydrolase enzyme that can be isolated from human pancreas. α-Amylase, Human Pancreas catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose. α-Amylase, Human Pancreas can be used in life science research .

HY-N8326

Maltononaose	Others	Others
Maltononaose is a linear oligosaccharide consisting of 9 glucose units linked by alpha-1, 4-glucoside bonds. Maltononaose is used as a substrate to study the subsites affinity of glucoamylase. Maltononaose can be used to determine the activity of amylase and to optimize the process of starch hydrolysis .

HY-178363

α-Amylase-IN-13	Amylases	Metabolic Disease Endocrinology
α-Amylase-IN-13 is an orally active, selective, brain-penetrant *α-amylase* inhibitor (IC₅₀ = 0.71 μM). α-Amylase-IN-13 inhibits α-amylase through a mixed type of inhibition mechanism. α-Amylase-IN-13 leads to a significant reduction in blood glucose level in diabetic rats. α-Amylase-IN-13 causes significant histopathological improvements in the kidney, liver, and pancreas. α-Amylase-IN-13 can be used for the study of diabetic complications .

HY-N0668R

Rubusoside (Standard)	GLUT Amylases NF-κB Reference Standards	Metabolic Disease Inflammation/Immunology Cancer
Rubusoside (Standard) is the analytical standard of Rubusoside. This product is intended for research and analytical applications. Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits *NF-κB and α-amylase* (α-amylase) .**

HY-168495

α-Amylase-IN-12	Amylases Glycosidase	Metabolic Disease
α-Amylase-IN-12 (Compound 5e) is an *α-amylase* inhibitor (IC₅₀: 0.15 mM) with a mixed inhibition. α-Amylase-IN-12 has an IC₅₀ of 9.40 mM against α-glucosidase. α-Amylase-IN-12 promotes glucose uptake in yeast cells and exhibits significant antiglycation activity at high concentrations. α-Amylase-IN-12 can be used for the research of diabetes .

HY-170796

α-Amylase-IN-11	Amylases	Metabolic Disease
α-Amylase-IN-11 (compound C5f) is an *α-Amylase* inhibitor (IC₅₀=0.56 μM) that can reduce the sugar level in vivo. α-Amylase-IN-11 has a moderate inhibitory effect on α-glucosidase (α-glucosidase), with IC₅₀=11.03 μM. α-Amylase-IN-11 can significantly reduce the glucose concentration in a mouse model and has the potential for use in diabetes research .

HY-155961

Antidiabetic agent 2	Dipeptidyl Peptidase Phosphatase Amylases Glycosidase	Metabolic Disease
Antidiabetic agent 2 (Compound 56) is a glucose-uptake promoter. Antidiabetic agent 2 inhibits DPP-4, PTP-1B, *α-amylase, and α-glucosidase* with IC₅₀s of 0.036, 0.042, 0.241, 0.185 μM. Antidiabetic agent 2 decreases blood glucose levels .

HY-N1425R

Tiliroside (Standard)	Reference Standards Others	Metabolic Disease
Tiliroside (Standard) is the analytical standard of Tiliroside. This product is intended for research and analytical applications. Tiliroside, a glycosidic flavonoid, possesses anti-diabetic activities. Tiliroside is a noncompetitive inhibitor of *α-amylase* with a K_i value of 84.2 μM. Tiliroside inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract .

HY-169404

PPARγ agonist 15	PPAR	Metabolic Disease
PPARγ agonist 15 (Compound 7c) is an agonist for PPARγ. PPARγ agonist 15 inhibits the expression of alpha-amylase (HPA) and alpha-glucosidase (HLAG) with IC₅₀ of 28.35 µM and 26.21 µM. PPARγ agonist 15 enhances glucose uptake in the L6 myotube cell. PPARγ agonist 15 improves glucose homeostasis, insulin sensitivity, and lipid metabolism in rat Streptozotocin (HY-13753)-induced diabetes model .

HY-159491

DPP-4-IN-11	Dipeptidyl Peptidase Glycosidase Amylases	Metabolic Disease
DPP-4-IN-11 (compound 10) is an orally active DPP-4 inhibitor (IC₅₀=2.75 μM) with anti-type 2 diabetes activity. DPP-4-IN-11 exerts its glucose-lowering effect by inhibiting the activities of α-glucosidase (IC₅₀=3.02 μM) and *α-amylase* (IC₅₀=3.3 μM) .

HY-168185

α-glucosidase/PTP1B-IN-1	Glycosidase Phosphatase Amylases	Metabolic Disease
α-glucosidase/PTP1B-IN-1 (compound 8a) is a potent α-glucosidase and PTP1B inhibitor with an IC₅₀ value of 66.3 μM and 47.0 μM, respectively. α-glucosidase/PTP1B-IN-1 exhibits excellent activities against *α-amylase* with an IC₅₀ of 30.62 μM. α-glucosidase/PTP1B-IN-1 can dock into the active pockets of α-glucosidase and PTP1B. α-glucosidase/PTP1B-IN-1 has potential to reduce the postprandial blood glucose and is used for Type 2 diabetes mellitus .

HY-N18049

Decussatin	Amylases	Metabolic Disease
Decussatin is an *α-Amylases* inhibitor isolated from the Tibetan medicinal plant Swertia mussotii. By inhibiting the catalytic activity of *α-Amylases, Decussatin reduces the hydrolysis of complex carbohydrates such as starch and the intestinal absorption of glucose, thereby lowering blood glucose* levels in the body. Decussatin shows no significant in vitro antibacterial or antifungal activity. Decussatin can be used for the research of type 2 diabetes .

HY-B2193H

α-Amylase, Porcine	Endogenous Metabolite	Metabolic Disease
α-Amylase, Porcine (EC 3.2.1.1) is a protein enzyme that hydrolyses alpha bonds of large, alpha-linked polysaccharides, such as starch and glycogen, yielding glucose and maltose.

HY-B2193E

α-Amylase, Bacteroides fragilis	Endogenous Metabolite	Metabolic Disease
α-Amylase, Bacteroides fragilis (EC 3.2.1.1) is a protein enzyme that hydrolyses alpha bonds of large, alpha-linked polysaccharides, such as starch and glycogen, yielding glucose and maltose.

HY-B2193D

α-Amylase, Escherichia coli	Endogenous Metabolite	Metabolic Disease
α-Amylase, Escherichia coli (EC 3.2.1.1) is a protein enzyme that hydrolyses alpha bonds of large, alpha-linked polysaccharides, such as starch and glycogen, yielding glucose and maltose.

HY-N17215

3,4,6-Tri-O-galloyl-D-glucose 3,4,6-Trigalloylglucose	Amylases Glycosidase	Metabolic Disease Inflammation/Immunology
3,4,6-Tri-O-galloyl-D-glucose (3,4,6-Trigalloylglucose) is an *α-amylase* (*porcine α-amylase* IC₅₀ = 334.6 μM; K_i = 307.5 μM) and α-glucosidase (yeast α-glucosidase IC₅₀ = 46.5 μM; K_i** = 39.9 μM) mixed type inhibitor. 3,4,6-Tri-O-galloyl-D-glucose exhibits free radical scavenging ability, ferric-reducing power, and antioxidant activity. 3,4,6-Tri-O-galloyl-D-glucose can be used for the research of diabetes .

HY-P2770A

β-Amylase, Sweet potato	Endogenous Metabolite	Metabolic Disease
β-Amylase, Sweet potato (EC 3.2.1.2) hydrolyzes the α-(1,4) glucan linkages in polysaccharides of three or more α-(1,4) linked D-glucose units.

HY-105528

MDL-25637	Glycosidase	Metabolic Disease
MDL-25637 is an α-glucosidase inhibitor. MDL-25637 can inhibit the activity of sucrose enzyme, maltase, isomaltase, glucose amylase, and trehalose in the intestinal tract of rats. MDL-25637 can be used in the research of diabetes .

HY-181683

Antidiabetic agent 8		Metabolic Disease
Antidiabetic agent 8 is an orally active multi-target inhibitor, with IC₅₀ values of 9.79, 6.36 and 19.08 μM against α-glucosidase, *α-amylase* and PTP1B, respectively. Antidiabetic agent 8 reduces postprandial blood glucose elevation. Antidiabetic agent 8 can be used in the research of type 2 diabetes .

Tiliroside 3 Publications Verification	Flavonols Flavonoids Classification of Application Fields Platanus occidentalis L. Phenols Polyphenols Metabolic Disease Platanaceae Plants Disease Research Fields Source Classification	Others
Tiliroside, a glycosidic flavonoid, possesses anti-diabetic activities. Tiliroside is a noncompetitive inhibitor of *α-amylase* with a K_i value of 84.2 μM. Tiliroside inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract .

α-Amylase 2 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Environmental Pollutants Amylases
α-Amylase is a hydrolase enzyme that catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose.

Rubusoside 2 Publications Verification	other families Classification of Application Fields Terpenoids Other Diseases Diterpenoids Plants Disease Research Fields Sweeteners Source Classification Food Research	GLUT Amylases NF-κB
Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits NF-κB and α-amylase (α-amylase) .

Maltononaose	Structural Classification Polysaccharides Microorganisms Saccharides Source Classification	Others
Maltononaose is a linear oligosaccharide consisting of 9 glucose units linked by alpha-1, 4-glucoside bonds. Maltononaose is used as a substrate to study the subsites affinity of glucoamylase. Maltononaose can be used to determine the activity of amylase and to optimize the process of starch hydrolysis .

Rubusoside (Standard)	Structural Classification other families Terpenoids Diterpenoids Plants Source Classification	GLUT Amylases NF-κB Reference Standards
Rubusoside (Standard) is the analytical standard of Rubusoside. This product is intended for research and analytical applications. Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits *NF-κB and α-amylase* (α-amylase) .**

Tiliroside (Standard)	Flavonoids Classification of Application Fields Platanus occidentalis L. Phenols Metabolic Disease Platanaceae Plants Disease Research Fields Source Classification	Reference Standards Others
Tiliroside (Standard) is the analytical standard of Tiliroside. This product is intended for research and analytical applications. Tiliroside, a glycosidic flavonoid, possesses anti-diabetic activities. Tiliroside is a noncompetitive inhibitor of *α-amylase* with a K_i value of 84.2 μM. Tiliroside inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract .

Decussatin	Structural Classification Monophenols Gentianaceae Phenols Swertia mussotii Franch. Plants Source Classification	Amylases
Decussatin is an *α-Amylases* inhibitor isolated from the Tibetan medicinal plant Swertia mussotii. By inhibiting the catalytic activity of *α-Amylases, Decussatin reduces the hydrolysis of complex carbohydrates such as starch and the intestinal absorption of glucose, thereby lowering blood glucose* levels in the body. Decussatin shows no significant in vitro antibacterial or antifungal activity. Decussatin can be used for the research of type 2 diabetes .

3,4,6-Tri-O-galloyl-D-glucose 3,4,6-Trigalloylglucose	Structural Classification Natural Products Euphorbia fischeriana Steud. Euphorbiaceae Plants Source Classification	Amylases Glycosidase
3,4,6-Tri-O-galloyl-D-glucose (3,4,6-Trigalloylglucose) is an *α-amylase* (*porcine α-amylase* IC₅₀ = 334.6 μM; K_i = 307.5 μM) and α-glucosidase (yeast α-glucosidase IC₅₀ = 46.5 μM; K_i** = 39.9 μM) mixed type inhibitor. 3,4,6-Tri-O-galloyl-D-glucose exhibits free radical scavenging ability, ferric-reducing power, and antioxidant activity. 3,4,6-Tri-O-galloyl-D-glucose can be used for the research of diabetes .

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glucose amylase

Inhibitors & Agonists

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Natural
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