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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
glutamatergic
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "glutamatergic" in MCE Product Catalog:
13
2
2 Cited Publications
Synonyms: 5'-GMP; 5'-guanosine monophosphate
Category:
Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
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2
2 Cited Publications
Cat. No.: HY-W010970
CAS No.: 5550-12-9
Synonyms: 5'-GMP disodium salt; 5'-guanosine monophosphate disodium salt
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2
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Cyclothiazide is a positive allosteric modulator of ionotropic AMPA-type glutamate receptors. Cyclothiazide inhibits GABAA receptors. Cyclothiazide is frequently used to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. Cyclothiazide can potentiate responses to kainate in hippocampal neurons. Cyclothiazide has effects on glutamatergic neurotransmission. Cyclothiazide also induces epileptiform EEG activity accompanying behavioral seizures .
Cat. No.: HY-17030
CAS No.: 77337-73-6
Synonyms: Calcium N-acetylhomotaurinate
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Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.
Cat. No.: HY-W402682
CAS No.: 1695562-36-7
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SXC2023 is a glutamatergic reagent and cystine-glutamate antiporter (System xc −) activator. SXC2023 can affect SLC7A11. SXC2023 is applicable to the research of colorectal cancer and trichotillomania .
Synonyms: 5'-GMP (Standard); 5'-guanosine monophosphate (Standard)
5'-Guanylic acid is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid also causes neuronal cell death at high concentrations .
Synonyms: (S)-3,4-Dicarboxyphenylglycine
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(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8a receptor agonist with an EC50 of 31 nM for human mGlu8a. (S)-3,4-DCPG inhibits Forskolin (HY-15371)-stimulated cAMP formation by activating mGlu8, and modulates presynaptic glutamatergic transmission and synaptic plasticity. (S)-3,4-DCPG can be used in research on inflammatory pain, neuropathic pain, autism spectrum disorder, and glutamatergic synaptic plasticity .
Cat. No.: HY-W110888
CAS No.: 3051-11-4
Cat. No.: HY-19411
CAS No.: 446031-79-4
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SSR180711 hydrochloride is an orally active, selective and reversible α7 acetylcholine nicotinic receptor (n-AChRs) partial agonist. SSR180711 hydrochloride can act on rat α7 n-AChR (Ki=22 nM; IC50=30 nM) and human α7 n-AChR (Ki=14 nM; IC50=18 nM). SSR180711 hydrochloride increases glutamatergic neurotransmission, ACh release and long-term potentiation (LTP) in the hippocampus .
Category:
Natural Products Immune System Disorder Neurological Disease Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields
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Cat. No.: HY-167822
CAS No.: 1531600-36-8
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Caramboxin is a phenylalanine-like α-amino acid neurotoxin found in star fruit (Averrhoa carambola) with glutamatergic ionotropic action. Caramboxin activates NMDA, AMPA, and kainate receptors while inhibiting GABA binding to synaptic membranes, shifting the CNS toward an excitatory state and exerting neurotoxic effects linked to star fruit ingestion. Caramboxin can be used for research on neurotoxicity and as a reference standard for toxicological studies .
Cat. No.: HY-168977
CAS No.: 903884-71-9
Synonyms: RL-007; FSV7-007
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Inidascamine is the modulator for cholinergic, glutamatergic, and GABAB receptor, and can be used for researchs of schizophrenia .
Cat. No.: HY-W747992
CAS No.: 2181-75-1
Cat. No.: HY-123272
CAS No.: 528859-04-3
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E6801 is a 5-HT6 receptor agonist that improves recognition memory by jointly modulating cholinergic and glutamatergic neurotransmission. E6801 can be used in studies of dementia, depression, obesity, epilepsy, etc .
Cat. No.: HY-133195
CAS No.: 13669-70-0
Synonyms: Fenazoxine
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Nefopam (Fenazoxine) is an orally active, non-opioid and non-steroidal centrally acting analgesic agent. Nefopam blocks voltage-sensitive sodium channels (IC50=27 μM) and modulates glutamatergic transmission in rodents. Nefopam can be used in studies of neuropathic pain, anticonvulsant, as well as the prevention of postoperative shivering and hiccups .
Cat. No.: HY-153172
CAS No.: 2274723-90-7
Synonyms: Phenylbenzothiazole-PEG4-OH; SPG302
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Tazbentetol (Phenylbenzothiazole-PEG4-OH) is a synaptogenic compound. Tazbentetol partially preserves inner retinal neurotransmission function and maintains retinal function. Tazbentetol increases dendritic spine glutamatergic synapses via cytoskeleton signaling pathways, enhances synaptic density both in vitro and in vivo, and restores glutamatergic synapses. Tazbentetol improves the progression of motor symptoms and enhances memory. Tazbentetol can be used in the research of glaucoma, diabetic retinopathy and amyotrophic lateral sclerosis .
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Aminophylline (Standard) is the analytical standard of Aminophylline (HY-B0140). This product is intended for research and analytical applications. Aminophylline is a competitive phosphodiesterase 3/4 (PDE3/4) inhibitor. Aminophylline also acts as an adenosine receptor antagonist. Aminophylline elevates intracellular cAMP levels via competitive inhibition of PDE3 and PDE4, antagonizes adenosine A1 receptor (ADORA1), regulates intracellular calcium signaling and synaptic vesicle cycling, upregulates the PPAR signaling pathway, and downregulates glutamatergic synaptic pathways simultaneously. Aminophylline can be used in research related to major depressive disorder, epilepsy, asthma, and chronic obstructive pulmonary disease (COPD) .
Cat. No.: HY-45609R
CAS No.: 150465-29-5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
