Tazbentetol
Based on 1 Customer Validation
Tazbentetol (Phenylbenzothiazole-PEG4-OH) is a synaptogenic compound. Tazbentetol partially preserves inner retinal neurotransmission function and maintains retinal function. Tazbentetol increases dendritic spine glutamatergic synapses via cytoskeleton signaling pathways, enhances synaptic density both in vitro and in vivo, and restores glutamatergic synapses. Tazbentetol improves the progression of motor symptoms and enhances memory. Tazbentetol can be used in the research of glaucoma, diabetic retinopathy and amyotrophic lateral sclerosis.
For research use only. We do not sell to patients.
- Purity: 98.63%
- CAS No.: 2274723-90-7
- Formula: C21H25NO5S
- Molecular Weight:403.49
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Tazbentetol increases glutamatergic dendritic spine synapse density in in vitro neuronal cultures within hours[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Tazbentetol (30 mg/kg; i.p.; daily; 8 weeks) mitigates RGC and synaptic loss and preserves inner retina neurotransmission in a mouse model of diabetic retinal neuropathy, with statistically significant improvements in peripheral RGC counts, pERG amplitude, and synaptophysin signal, without altering blood sugar levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57Bl/6J mice[1]
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Dosage:30 mg/kg
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Administration:i.p.; daily; 8 weeks
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Result:Increased middle retina RGC counts to 3506 cells.
Increased peripheral retina RGC counts to 2837 cells.
Increased pERG amplitude to 17.83 mV.
Increased synaptophysin inner plexiform layer (IPL) signal to 40.9 a.u.
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Animal Model:db/db mice (16-week-old)[1]
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Dosage:30 mg/kg
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Administration:i.p.; daily; 8 weeks
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Result:Increased peripheral retina RGC counts to 2776 cells.
Increased pERG amplitude to 20.7 mV.
Increased synaptophysin inner plexiform layer (IPL) signal to 15.7 a.u.
Left blood sugar levels unchanged at 392.5 mg/dl compared to control.
Chemical Information
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CAS No. 2274723-90-7
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Appearance Solid
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Molecular Weight 403.49
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Formula C21H25NO5S
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Color White to off-white
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SMILES
OCCOCCOCCOCCOC1=CC=C(C2=NC3=C(S2)C=CC=C3)C=C1
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Synonyms
Phenylbenzothiazole-PEG4-OH; SPG302
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (247.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4784 mL | 12.3919 mL | 24.7838 mL | 61.9594 mL |
| 5 mM | 0.4957 mL | 2.4784 mL | 4.9568 mL | 12.3919 mL | |
| 10 mM | 0.2478 mL | 1.2392 mL | 2.4784 mL | 6.1959 mL | |
| 15 mM | 0.1652 mL | 0.8261 mL | 1.6523 mL | 4.1306 mL | |
| 20 mM | 0.1239 mL | 0.6196 mL | 1.2392 mL | 3.0980 mL | |
| 25 mM | 0.0991 mL | 0.4957 mL | 0.9914 mL | 2.4784 mL | |
| 30 mM | 0.0826 mL | 0.4131 mL | 0.8261 mL | 2.0653 mL | |
| 40 mM | 0.0620 mL | 0.3098 mL | 0.6196 mL | 1.5490 mL | |
| 50 mM | 0.0496 mL | 0.2478 mL | 0.4957 mL | 1.2392 mL | |
| 60 mM | 0.0413 mL | 0.2065 mL | 0.4131 mL | 1.0327 mL | |
| 80 mM | 0.0310 mL | 0.1549 mL | 0.3098 mL | 0.7745 mL | |
| 100 mM | 0.0248 mL | 0.1239 mL | 0.2478 mL | 0.6196 mL |
Tazbentetol Related Classifications
HY-153172 Related Classifications
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Keywords
- Tazbentetol
- 2274723-90-7
- Phenylbenzothiazole-PEG4-OH
- SPG302
- SPG302
- SPG 302
- SPG-302
- Drug Intermediate
- mouse model
- retinal ganglion cell
- inner retina neurotransmission
- glaucoma
- amyotrophic lateral sclerosis
- glutamatergic synapses
- retinal function
- neuronal cultures
- diabetic retinal neuropathy
- dendritic spine glutamatergic synapses
- Inhibitor
- inhibitor
- inhibit