2274723-90-7
Chemical Structure
Tazbentetol
Synonym(s): Phenylbenzothiazole-PEG4-OH; SPG302
- CAS No.: 2274723-90-7
- Formula:C21H25NO5S
- Molecular Weight:403.49
IUPAC Name: 2-(2-(2-(2-(4-(benzo[d]thiazol-2-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethan-1-ol
InChIKey: XSAIPEACQNRHOL-UHFFFAOYSA-N
SMILES: OCCOCCOCCOCCOC1=CC=C(C2=NC3=C(S2)C=CC=C3)C=C1
Biological Activity: Tazbentetol (Phenylbenzothiazole-PEG4-OH) is a synaptogenic compound. Tazbentetol partially preserves inner retinal neurotransmission function and maintains retinal function. Tazbentetol increases dendritic spine glutamatergic synapses via cytoskeleton signaling pathways, enhances synaptic density both in vitro and in vivo, and restores glutamatergic synapses. Tazbentetol improves the progression of motor symptoms and enhances memory. Tazbentetol can be used in the research of glaucoma, diabetic retinopathy and amyotrophic lateral sclerosis[1][2].
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Tazbentetol | 98.63% | Tazbentetol (Phenylbenzothiazole-PEG4-OH) is a synaptogenic compound. Tazbentetol partially preserves inner retinal neurotransmission function and maintains retinal function. Tazbentetol increases dendritic spine glutamatergic synapses via cytoskeleton signaling pathways, enhances synaptic density both in vitro and in vivo, and restores glutamatergic synapses. Tazbentetol improves the progression of motor symptoms and enhances memory. Tazbentetol can be used in the research of glaucoma, diabetic retinopathy and amyotrophic lateral sclerosis. | ||||||||||||||||||||
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- [1]. Vanderklish P, et al. Neuroprotective effects of Tazbentetol (SPG302) in mouse models of glaucoma and diabetic retinal neuropathy: preservation of visual function and protection of the inner retina[J]. Investigative Ophthalmology & Visual Science, 2026, 67(7): 4372-4372.
- [2]. Vanderklish P W, et al. Safety, Tolerability and Efficacy of Tazbententol in Healthy Volunteers and ALS Participants: An Adaptive Phase 1/2a Trial[J]. Available at SSRN 6378324.
Keywords
