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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
49 Results for "
heat stress
" in MedChemExpress (MCE) Product Catalog:
Products (49)
49 Results for "heat stress" in MCE Product Catalog:
43
Target:
12
12 Cited Publications
Target:
Research Areas:
IXA4 is a highly selective, non-toxic IRE1/XBP1s activator. IXA4 activates IRE1/XBP1s signaling without globally activating the unfolded protein response (UPR) or other stress-responsive signaling pathways (e.g., the heat shock response or oxidative stress response). IXA4 reduces secretion of APP through IRE1 activation .
7
7 Cited Publications
Synonyms: Trimethylglycine; carboxy-N,N,N-trimethylmethanaminium
3
3 Cited Publications
Research Areas:
Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs .
1
1 Cited Publications
Cat. No.: HY-N6924
CAS No.: 80930-74-1
Category:
Infection Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Panax japonicas C. A. Mey. Metabolic Disease Plants Disease Research Fields Araliaceae Saccharides
Target:
1
1 Cited Publications
Cat. No.: HY-P703226
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSP90B1; HEL35; Prev. TRA1; heat Shock Protein 90kDa Beta Family Member 1; Endoplasmin; stress-Inducible Tumor Rejection Antigen Gp96; GRP94; Endothelial Cell (HBMEC) Glycoprotein; heat Shock Protein 90 KDa Beta Member 1; Epididymis Luminal Protein 35; GP
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P70933
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPB8; Alpha-Crystallin C Chain; heat Shock Protein Family B (Small) Member 8; Protein Kinase H11; E2IG1; HSPB8-N1; HSP22; HSPB8-N2; CMT2L; DHMN2; H11; HMN2A; Small stress Protein-Like Protein HSP22; HMND2; heat Shock Protein Family B Member 8; MFM13; Hea
Species:
Human
Source:
E. coli
Cat. No.: HY-W012382
CAS No.: 537-55-3
Category:
Human Gut Microbiota Metabolites Monophenols Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endocrine diseases Phenols Endogenous metabolite Disease Research Fields
Target:
Synonyms: Olomoucin
Research Areas:
Butyrolactone I is an orally active and ATP-competitive inhibitor of CDK1. Butyrolactone I inhibits NF-κB, cdc2 kinase, Bax, ROS production, modulates the PERK/CHOP. Butyrolactone I mitigates heat-stress-induced Apoptosis. Butyrolactone I shows anti-inflammatory and intestinal protective activity. Butyrolactone I has antitumor effects against non-small cell lung, small cell lung, prostate cancer and leukemia. Butyrolactone I can be used in NASH research .
Cat. No.: HY-W015466
CAS No.: 96-81-1
Target:
PROTACs CDK AAK1 Cyclin G-associated Kinase (GAK) Salt-inducible Kinase (SIK) LIM Kinase (LIMK) Wee1 SnRK
Research Areas:
RSS0680 is a small noncoding RNA (sRNA) targeting the mRNA ribosome binding site (RBS) and a PROTAC. RSS0680 competitively binds to RBS through the conserved CCUCCUCCC anti-Shine-Dalgarno (aSD) sequence and inhibits the translation initiation of target genes. RSS0680 can interact with the DUF1127 protein CcaF1, regulate its own stability and participate in bacterial oxidative stress defense, enhancing the host's resistance to heat shock and oxidative damage by affecting pathways such as C1 metabolism and pyruvate dehydrogenase complex. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used to study diseases or disorders mediated by aberrant kinase activity and regulatory mechanisms of noncoding RNAs in α-proteobacteria[1][2].
Synonyms: Trimethylglycine (Standard); carboxy-N,N,N-trimethylmethanaminium (Standard)
Cat. No.: HY-N0293R
CAS No.: 23180-57-6
Synonyms: Peoniflorin (Standard)
Target:
Cat. No.: HY-W012382S
Cat. No.: HY-141564
CAS No.: 2837939-81-6
Target:
Research Areas:
RyR1-IN-1 (Compound 1) is a RyR1 inhibitor with an IC50 of 12 nM. RyR1-IN-1 blocks Ca²⁺ release and inhibits muscle tetany caused by caffeine and heat stress. RyR1-IN-1 can completely prevent the increase in body temperature and death caused by isoflurane and heat stress. RyR1-IN-1 can be used for the study of heat stroke .
Cat. No.: HY-B0710S
CAS No.: 309762-22-9
Synonyms: Trimethylglycine-13C3; Carboxy-N,N,N-trimethylmethanaminium-13C3
CCT245232 is a potent inhibitor of heat shock factor 1 (HSF1). HSF1 is the master regulator of the heat shock response, in which multiple genes are induced in response to temperature increase and other stresses. CCT245232 has the potential for the research of proliferative diseases, such as cancer (extracted from patent WO2015049535A1) .
Cat. No.: HY-P3130
CAS No.: 348626-74-4
Target:
Research Areas:
Cat. No.: HY-W012382R
CAS No.: 537-55-3
Cat. No.: HY-118487A
CAS No.: 940061-39-2
Target:
Research Areas:
OB-24 free base is a compound that potently and selectively inhibits heme oxygenase 1 (HO-1) and has the potential to inhibit advanced prostate cancer. OB-24 significantly reduces protein carbonylation and the formation of reactive oxygen species by selectively inhibiting HO-1 activity in prostate cancer cells. OB-24 significantly inhibited cell proliferation in vitro and inhibited tumor growth and lymph node and lung metastasis in vivo. OB-24 exhibits powerful synergy when used in combination with Taxol .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
