845959-55-9
Chemical Structure
Mitoquinol
- CAS No.: 845959-55-9
- Formula:C38H49O7PS
- Molecular Weight:680.83
IUPAC Name: (10-(2,5-dihydroxy-3,4-dimethoxy-6-methylphenyl)decyl)triphenylphosphonium methanesulfonate
InChIKey: WPMXVYGZUOSRAN-UHFFFAOYSA-N
SMILES: CC1=C(CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(O)=C(OC)C(OC)=C1O.CS(=O)([O-])=O
Biological Activity: Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mitoquinol | 98.00% | Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs. | ||||||||||||||||||||
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Mitoquinol-d15 | Mitoquinol-d15 is deuterium labeled Mitoquinol (HY-124410). Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs. | |||||||||||||||||||||
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References
- [1]. Fink BD,et al. Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells. J Pharmacol Exp Ther. 2012 Sep;342(3):709-19. [Content Brief]
- [2]. Mayorga EJ, et al. Therapeutic effects of mitoquinol during an acute heat stress challenge in growing barrows. J Anim Sci. 2024 Jan 3;102:skae161. [Content Brief]
- [3]. Pant BD, et al. Mitoquinol improves phagocytosis and glycolysis in ethanol-exposed macrophages via HIF-1α-PFKP axis. J Immunol. 2025 May 12:vkaf078. [Content Brief]
