549 Results for "

helper 2/3

" in MedChemExpress (MCE) Product Catalog:
Products (549)

549 Results for "helper 2/3" in MCE Product Catalog:

28
Tezacaftor
Tezacaftor
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28 Publications Verification
Cat. No.: HY-15448
CAS No.: 1152311-62-0
Purity:  99.85%
Synonyms: VX-661
Target:  

CFTR

Research Areas:  

Cancer

Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation [2] .
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22
Uric acid
Uric acid
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22 Cited Publications
Cat. No.: HY-B2130
CAS No.: 69-93-2
Category:  

Endocrine diseases Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Inflammation/Immunology Cancer

Target:  

Endogenous Metabolite Reactive Oxygen Species (ROS)

Uric acid is an orally active oxygen free radical scavenger that helps maintain stable blood pressure and combat oxidative stress. Uric acid can scavenge ROS, such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation. Uric acid can be used as a modeling agent in research on hyperuricemia-induced hypertension models [2] .
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22
Uric acid sodium
Uric acid sodium
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22 Cited Publications
Cat. No.: HY-B2130A
CAS No.: 1198-77-2
Synonyms: Monosodium urate
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Reactive Oxygen Species (ROS)

Uric acid sodium is an orally active oxygen free radical scavenger that helps maintain stable blood pressure and combat oxidative stress. Uric acid sodium can scavenge ROS, such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation. Uric acid sodium can be used as a modeling agent in research on hyperuricemia-induced hypertension models [2] .
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20
Dexrazoxane hydrochloride
Dexrazoxane hydrochloride
0 Images
20 Cited Publications
Cat. No.: HY-76201
CAS No.: 149003-01-0
Synonyms: ICRF-187 hydrochloride; ADR-529 hydrochloride; NSC-169780 hydrochloride
Target:  

Apoptosis Ferroptosis

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer

Dexrazoxane hydrochloride (ICRF-187 hydrochloride) is a heart protectant that can help preserve ovarian function and fertility. Dexrazoxane hydrochloride has antioxidant and anti-inflammatory properties, can cross the blood-brain barrier, improves motor function disorders, and offers neuroprotective effects, making it useful in the study of neurodegenerative diseases [2] .
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20
C12-200
C12-200
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20 Cited Publications
Cat. No.: HY-145405
CAS No.: 1220890-25-4
Purity:  99.91%
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B [2] .
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19
DOTAP chloride
DOTAP chloride
0 Images
19 Cited Publications
Cat. No.: HY-112754A
CAS No.: 132172-61-3
Purity:  99.91%
Synonyms: 1,2-Dioleoyl-3-trimethylammonium-propane chloride
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .
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12
DOPE
DOPE
0 Images
12 Cited Publications
Cat. No.: HY-112005
CAS No.: 4004-05-1
Purity:  98.80%
Synonyms: Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
DOPE (Dioleoylphosphatidylethanolamine) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA .
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12
Oil Red O
Oil Red O
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12 Cited Publications
Cat. No.: HY-D1168
CAS No.: 1320-06-5
Oil Red O is a fat-soluble diazol dye, with a maximum absorption at 518 nm. Oil Red O stains neutral lipids and cholesteryl esters but not biological membranes. Oil Red O can be used for detecting and quantifying hepatic steatosis in mouse liver biopsies. Oil Red O staining efficiently helps to visualize the radical changes that occur in tissues as metabolic disease occurs and progresses .
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10
D-(+)-Trehalose
D-(+)-Trehalose
0 Images
10 Cited Publications
Cat. No.: HY-N1132
CAS No.: 99-20-7
Synonyms: D-Trehalose; α,α-Trehalose
Category:  

Polysaccharides Other Diseases Endogenous metabolite Disease Research Fields Saccharides

Target:  

Endogenous Metabolite

D-(+)-Trehalose (α,α-Trehalose) is an orally active disaccharide, showing anti-desiccant and cryopreservative activities. D-(+)-Trehalose acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon. D-(+)-Trehalose can be used as a food ingredient and pharmaceutical excipient [2] .
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6
LL-37, human
LL-37, human
0 Images
6 Cited Publications
Cat. No.: HY-P1222
CAS No.: 154947-66-7
Target:  

Bacterial

Research Areas:  

Infection

LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing [2] .
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6
LL-37, human acetate
LL-37, human acetate
0 Images
6 Cited Publications
Cat. No.: HY-P1222B
Target:  

Bacterial

Research Areas:  

Infection Inflammation/Immunology

LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing [2] .
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6
LL-37, human TFA
LL-37, human TFA
0 Images
6 Cited Publications
Cat. No.: HY-P1222A
Target:  

Bacterial

Research Areas:  

Infection

LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human TFA could help protect the cornea from infection and modulates wound healing [2] .
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6
Betaine
Betaine
0 Images
6 Cited Publications
Cat. No.: HY-B0710
CAS No.: 107-43-7
Synonyms: Trimethylglycine; carboxy-N,N,N-trimethylmethanaminium
Category:  

Natural Products other families Microorganisms Animals Disease markers Metabolic Disease Plants Endogenous metabolite Disease Research Fields Cancer

Target:  

Environmental Pollutants Endogenous Metabolite

Betaine (Trimethylglycine) is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns [1,2]. Betaine is found ubiquitously in plants, animals, microorganisms, and rich dietary sources including seafood, spinach, and wheat bran. Betaine also acts as an osmolyte, to maintain the avian’s cellular water and ion balance to improve the avian’s capacity against heat stress via preventing dehydration and osmotic inactivation. It helps in maintaining the protective osmolytic activity, especially in heat-stressed birds. Betaine may promote various intestinal microbes against osmotic variations and thus improve microbial fermentation activity .
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5
L-Cystine
L-Cystine
0 Images
5 Cited Publications
Cat. No.: HY-N0394
CAS No.: 56-89-3
Category:  

Human Gut Microbiota Metabolites Other Diseases Amino acids Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Ferroptosis ROS Kinase Keap1-Nrf2 Reactive Oxygen Species (ROS)

L-Cystine is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-cystine reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine is promising for research of cystinuria and kidney stones [2]
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5
L-Cystine dihydrochloride
L-Cystine dihydrochloride
0 Images
5 Cited Publications
Cat. No.: HY-W009203
CAS No.: 30925-07-6
Category:  

Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Apoptosis Keap1-Nrf2 Reactive Oxygen Species (ROS) Ferroptosis

L-Cystine dihydrochloride is the dihydrochloride salt form of L-Cystine (HY-N0394). L-Cystine dihydrochloride elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-cystine dihydrochloride reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine dihydrochloride combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine dihydrochloride is promising for research of cystinuria and kidney stones [2]
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5
Fluorescein-5-maleimide
Fluorescein-5-maleimide
0 Images
5 Cited Publications
Cat. No.: HY-D0098
CAS No.: 75350-46-8
Synonyms: N-(5-Fluoresceinyl)maleimide
Fluorescein-5-maleimide (N-(5-Fluoresceinyl)maleimide) is a fluorescent dye. Fluorescein-5-maleimide can be used to detect the redox state of thiols in eukaryotic cells. Fluorescein-5-maleimide can label peptides and is used to detect negatively charged nanoparticles. Fluorescein-5-maleimide can also label actin to explore its interaction with cardiac myosin-binding protein C (cMyBP-C), which helps in developing small molecule modulators for heart failure. Fluorescein-5-maleimide can screen mutant proteins that contain cysteine residues. The excitation wavelength of Fluorescein-5-maleimide is 494 nm, and the emission wavelength is 519 nm [2] .
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4
Sincalide
Sincalide
0 Images
4 Cited Publications
Cat. No.: HY-P0093
CAS No.: 25126-32-3
Synonyms: Cholecystokinin octapeptide; CCK-8; SQ19844
Target:  

Cholecystokinin Receptor Apoptosis PI3K Akt

Research Areas:  

Infection Cancer

Sincalide (Cholecystokinin octapeptide, CCK-8) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK. Sincalide can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK [2] .
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4
Sincalide ammonium
Sincalide ammonium
0 Images
4 Cited Publications
Cat. No.: HY-P0093A
CAS No.: 70706-98-8
Synonyms: Cholecystokinin octapeptide ammonium; CCK-8 ammonium; SQ19844 ammonium
Target:  

Cholecystokinin Receptor Apoptosis PI3K Akt

Research Areas:  

Infection Cancer

Sincalide ammonium (Cholecystokinin octapeptide ammonium, CCK-8 ammonium) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK. CCK‐8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide ammonium can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK [2] .
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2
Glatiramer acetate
Glatiramer acetate
0 Images
2 Cited Publications
Cat. No.: HY-109520
CAS No.: 147245-92-9
Purity:  ≥98.0%
Target:  

MHC

Research Areas:  

Inflammation/Immunology Cancer

Glatiramer acetate, a synthetic analogue of myelin basic protein and an immunomodulating agent, inhibits Experimental autoimmune encephalomyelitis (EAE), and can be used for the research of multiple sclerosis. Glatiramer acetate exhibits strong and promiscuous binding to MHC molecules and consequent competition with various myelin antigens for their presentation to T cells. A further aspect of its action is potent induction of specific suppressor cells of the T helper 2 (Th2) type that migrate to the brain and lead to in situ bystander suppression [2] .
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2
Eleutheroside E
Eleutheroside E
0 Images
2 Cited Publications
Cat. No.: HY-N0272
CAS No.: 39432-56-9
Category:  

Lignans Acanthopanax senticosus (Rupr. et Maxim.) Harms Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology Araliaceae

Target:  

Apoptosis NF-κB

Eleutheroside E is an important component of ginseng that can be taken orally. Eleutheroside E has anti-inflammatory and antioxidant properties, and it helps reduce apoptosis in heart cells caused by hypoxia-reoxygenation (H/R) damage. Eleutheroside E can improve type 2 diabetes, enhance cognitive function, and has neuroprotective effects [2] .
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