1. Others
  2. Others
  3. Glatiramer acetate

Glatiramer acetate 

Cat. No.: HY-109520
Handling Instructions

Glatiramer acetate, a synthetic analogue of myelin basic protein and an immunomodulating agent, can be used for the research of multiple sclerosis. Glatiramer acetate exhibits strong and promiscuous binding to MHC molecules and consequent competition with various myelin antigens for their presentation to T cells. A further aspect of its action is potent induction of specific suppressor cells of the T helper 2 (Th2) type that migrate to the brain and lead to in situ bystander suppression.

For research use only. We do not sell to patients.

Glatiramer acetate Chemical Structure

Glatiramer acetate Chemical Structure

CAS No. : 147245-92-9

Size Price Stock
5 mg USD 90 Ask For Quote & Lead Time
10 mg USD 160 Ask For Quote & Lead Time
25 mg USD 280 Ask For Quote & Lead Time
50 mg USD 390 Ask For Quote & Lead Time
100 mg USD 580 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Glatiramer acetate, a synthetic analogue of myelin basic protein and an immunomodulating agent, can be used for the research of multiple sclerosis. Glatiramer acetate exhibits strong and promiscuous binding to MHC molecules and consequent competition with various myelin antigens for their presentation to T cells. A further aspect of its action is potent induction of specific suppressor cells of the T helper 2 (Th2) type that migrate to the brain and lead to in situ bystander suppression[1][2][3].

In Vitro

Glatiramer acetate (25-100 mg/kg; S.c; 5 days) increase BDNF levels[3].
In huntington’s disease (HD) mouse model, the N171-82Q transgenic mouse line, which exhibits a more rapidly progressing disease course. Glatiramer acetate (1 mg/mouse; s.c.; 5×week) beginning at 8 weeks of age and continuing until 20 weeks of age, which is near the age of death due to the disease. Glatiramer acetate elicited improves performance on several motor function measures. Glatiramer acetate significantly improves the performance of N171-82Q transgenic mice at 15 weeks of age in the rotarod test measured over the course of 4 days[3].

Formula

(C₉H₁₁NO₃.C₆H₁₄N₂O₂.C₅H₉NO₄.C₃H₇NO₂)x.xC₂H₄O₂

CAS No.

147245-92-9

SMILES

OC(CC[[email protected]](N)C(O)=O)=O.OC([[email protected]@H](N)CC1=CC=C(O)C=C1)=O.OC([[email protected]@H](N)C)=O.NCCCC[[email protected]](N)C(O)=O.O=C(C)O.[x].[x].[x].[x].[x]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GlatiramerOthersimmunomodulatorymultiplesclerosisTcellspolypeptideanalogueautoimmuneencephalomyelitishelper 2/3Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Glatiramer acetate
Cat. No.:
HY-109520
Quantity:
MCE Japan Authorized Agent: