3 Results for "

human bronchial smooth muscle cell

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "human bronchial smooth muscle cell" in MCE Product Catalog:

Xaluritamig
Xaluritamig
0 Images
Cat. No.: HY-P990688
CAS No.: 2559056-68-5
Synonyms: AMG-509

Target:  

CD3

Research Areas:  

Cancer

Xaluritamig (AMG-509) is a bispecific T cell engager and cytolytic agent with a Kd of 27.6 nM for human CD3ε. Xaluritamig binds to CD3ε via an anti-CD3 single-chain variable fragment (scFv) domain, and to STEAP1 via a bispecific anti-STEAP1 antigen-binding fragment (Fab) domain, thereby recruiting and activating T cells and forming a bridge between T cells and STEAP1-expressing cancer cells. Xaluritamig induces T cell-mediated redirected cytotoxicity, tumor cell lysis, cytokine release, CD8 + T cell activation and expansion, as well as tumor stasis or regression. Xaluritamig contains an Fc domain with no effector function, which prolongs serum half-life, exhibits only minimal activity against cells with low STEAP1 expression and normal cells, and shows extremely low target-related off-tumor toxicity in cynomolgus monkeys. Xaluritamig is used in STEAP1×CD3 XmAb 2+1 immunotherapy and in research on metastatic castration-resistant prostate cancer and Ewing sarcoma .
loading...
    loading...
View All Sizes
Litorin
Litorin
0 Images
Cat. No.: HY-103281
CAS No.: 55749-97-8
Purity:  99.51%
Category:  

Alkaloids Animals Metabolic Disease Plants Solanaceae Disease Research Fields Datura metel Linn. Indole Alkaloids

Target:  

Bombesin Receptor

Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo .
loading...
    loading...
View All Sizes
Levalbuterol hemitartrate
Levalbuterol hemitartrate
0 Images
Cat. No.: HY-17457
CAS No.: 661464-94-4
Synonyms: Levosalbutamol hemitartrate
Target:  

Adrenergic Receptor PI3K

Research Areas:  

Inflammation/Immunology

Levalbuterol (Levosalbutamol) hemitartrate is a β2-adrenergic receptor agonist and PI3K inhibitor. Levalbuterol hemitartrate inhibits PI3K activity, reduces NF-κB and Rb protein expression, activates the cAMP/PKA pathway, and stimulates cAMP release. Levalbuterol hemitartrate relaxes airway smooth muscle, reduces intracellular calcium levels, and inhibits spasmogen-induced contractions. Levalbuterol hemitartrate can be used for the research of moderate-to-severe asthma .
loading...
    loading...
View All Sizes
Assay Types