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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
human dopamine neurons
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "human dopamine neurons" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-N2411
CAS No.: 60314-89-8
Target:
Cat. No.: HY-10431G
CAS No.: 301836-41-9
Cat. No.: HY-15147G
CAS No.: 284028-89-3
Cat. No.: HY-W049881
CAS No.: 2521-07-5
Target:
Research Areas:
9-Methyl-β-carboline is a monoamine oxidase inhibitor and dopaminergic modulator, with an IC50 of 1 μM against human MAO-A and an IC50 of 15.5 μM against human MAO-B. 9-Methyl-β-carboline possesses cognitive enhancement potential and can cross the blood-brain barrier. 9-Methyl-β-carboline increases dopamine levels by inhibiting monoamine oxidase activity and microglial proliferation. 9-Methyl-β-carboline activates PKA/PKC and mitochondrial respiratory chain complex I, promotes neurotrophic factor expression and reduces α-synuclein (α-synuclein) levels, thereby reversing neurotoxin-induced dopaminergic neuron damage. 9-Methyl-β-carboline also regulates the PI3K pathway and exerts an anti-proliferative effect on astrocytes. 9-Methyl-β-carboline is widely used in Parkinson's disease-related studies .
Cat. No.: HY-W125425
CAS No.: 2758-98-7
Synonyms: Methyl piperazine-2-carboxylate; METTL3 activator-1 free base
Research Areas:
CHMA1004 (Methyl piperazine-2-carboxylate; METTL3 activator-1 free base) is a METTL3/METTL14/WTAP methyltransferase complex activator . CHMA1004 exhibits neuroprotective and anxiolytic potential by enhancing m 6A methylation modification of RNA. CHMA1004 promotes HIV replication in an infection context. CHMA1004 can be used in studies related to anxiety disorders and HIV-1 infection .
Cat. No.: HY-138967
CAS No.: 2095489-35-1
Research Areas:
BRF110 is an orally active, blood-brain barrier-penetrant Nurr1-RXRα heterodimer activator with an EC50 of 0.9 μM in human systems. BRF110 increases the mRNA level of BDNF, upregulates the transcription of TH, AADC and GCH1 to elevate striatal dopamine levels. BRF110 exhibits neuroprotective activity against MPP +-induced cytotoxicity. BRF110 prevents dopaminergic neuron death, protects nerve cells from toxic damage, and improves motor coordination in mouse models. BRF110 can be used in research related to Parkinson's disease .
Cat. No.: HY-174589
Target:
Research Areas:
Human LMX1A mRNA encodes the human LIM homeobox transcription factor 1 alpha (LMX1A) protein, a homeodomain and LIM-domain containing protein. LMX1A is a transcription factor that acts as a positive regulator of insulin gene transcription. It also plays a role in the development of dopamine producing neurons during embryogenesis.
Cat. No.: HY-E70910
Target:
Research Areas:
Dopamine β-monooxygenase, Human (EC 1.14.17.1) is a copper-containing monooxygenase that converts dopamine into norepinephrine in noradrenergic neurons, adrenergic neurons, and adrenacentrocytes.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
