2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. XAV-939

XAV-939 (GMP) is XAV-939 (HY-15347) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. XAV-939 is a tankyrase inhibitor.

For research use only. We do not sell to patients.

XAV-939

XAV-939 Chemical Structure

CAS No. : 284028-89-3

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XAV-939 Related Antibodies

Top Publications Citing Use of Products

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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  • Purity & Documentation

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Description

XAV-939 (GMP) is XAV-939 (HY-15347) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. XAV-939 is a tankyrase inhibitor[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
12.3 μM
Compound: XAV939
Growth inhibition of human A549 cells after 72 hrs by MTT assay
Growth inhibition of human A549 cells after 72 hrs by MTT assay
[PMID: 29934219]
COLO 320DM GI50
17 μM
Compound: XAV939
Antiproliferative activity against human COLO320DM cells assessed as inhibition of cell growth measured after 4 days by CellTiter-Glo assay
Antiproliferative activity against human COLO320DM cells assessed as inhibition of cell growth measured after 4 days by CellTiter-Glo assay
[PMID: 30883102]
DLD-1 IC50
0.707 μM
Compound: 1, XAV-939
Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assay
Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assay
[PMID: 25299683]
HEK-293T IC50
51 nM
Compound: 2, XAV939
Inhibition of beta-casein-dependent canonical Wnt3 pathway in human HEK293T cells by luciferase reporter gene assay
Inhibition of beta-casein-dependent canonical Wnt3 pathway in human HEK293T cells by luciferase reporter gene assay
[PMID: 22191557]
HEK293 IC50
0.078 μM
Compound: 1, XAV939
Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay
Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay
[PMID: 22260203]
HEK293 IC50
0.078 μM
Compound: 1, XAV939
Inhibition of WNT3A signaling in HEK293 cells by luciferase reporter gene assay in presence of forskolin
Inhibition of WNT3A signaling in HEK293 cells by luciferase reporter gene assay in presence of forskolin
[PMID: 23844574]
HEK293 IC50
0.078 μM
Compound: 1, XAV939
Inhibition of Wnt signaling in human HEK293 cells assessed as inhibition of forskolin-induced cAMP response element activation by STF luciferase reporter gene assay
Inhibition of Wnt signaling in human HEK293 cells assessed as inhibition of forskolin-induced cAMP response element activation by STF luciferase reporter gene assay
[PMID: 23879431]
HEK293 IC50
272 μM
Compound: 3, XAV939
Inhibition of Tankyrase in human HEK293 cells assessed as inhibition of Wnt pathway by Wnt3a-induced STF assay
Inhibition of Tankyrase in human HEK293 cells assessed as inhibition of Wnt pathway by Wnt3a-induced STF assay
[PMID: 23316926]
SW480 EC50
0.371 μM
Compound: 1, XAV939
Stabilization of Axin2 in human SW480 cells after 24 hrs by sandwich ELISA
Stabilization of Axin2 in human SW480 cells after 24 hrs by sandwich ELISA
[PMID: 22260203]
SW480 GI50
> 50 μM
Compound: XAV939
Growth inhibition of human SW480 cells by Cell-titer-fluor reagent based assay
Growth inhibition of human SW480 cells by Cell-titer-fluor reagent based assay
[PMID: 31769984]
Sf21 IC50
0.0053 μM
Compound: 1, XAV939
Inhibition of N-terminal GST-tagged TNKS2 (unknown origin) expressed in baculovirus infected sf21 cells after 60 mins by LC-MS analysis
Inhibition of N-terminal GST-tagged TNKS2 (unknown origin) expressed in baculovirus infected sf21 cells after 60 mins by LC-MS analysis
[PMID: 23879431]
Sf21 IC50
17 nM
Compound: 5; XAV939
Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrate addition measured after 30 mins
Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrate addition measured after 30 mins
[PMID: 27163581]
Sf9 IC50
2.1 nM
Compound: XAV939
Inhibition of human N-terminal GST-tagged TNKS2 (667 to 1166 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate measured after 1 hr by horseradish peroxidase-coupled chemiluminescence assay
Inhibition of human N-terminal GST-tagged TNKS2 (667 to 1166 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate measured after 1 hr by horseradish peroxidase-coupled chemiluminescence assay
[PMID: 31042381]
Sf9 IC50
4.2 nM
Compound: XAV939
Inhibition of human N-terminal GST-tagged TNKS1 (1001 to 1327 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate measured after 1 hr by horseradish peroxidase-coupled chemiluminescence assay
Inhibition of human N-terminal GST-tagged TNKS1 (1001 to 1327 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate measured after 1 hr by horseradish peroxidase-coupled chemiluminescence assay
[PMID: 31042381]
In Vitro

XAV-939 (GMP) (5 μM; 2 μM for 3 days; 1 μM) induces human pluripotent stem cells (hPSCs) to post-mitotic cortical neurons differentiation[1].
XAV939 (GMP) promotes anterior CNS identity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

XAV-939 Related Antibodies

RT-PCR[1]

Cell Line: Human pluripotent stem cells (hPSCs)
Concentration: 5 μM, 2 μM, 1 μM
Incubation Time: 3 days
Result: Showed downregulation of the pluripotency marker OCT4 and induction of neural and neuronal markers PAX6, FOXG1 and DCX, as well as markers of early born cortical neurons, including TBR1 (preplate, subplate and layer VI) and REELIN, in LSB+X/P/S/D conditions.
Molecular Weight

312.31

Formula

C14H11F3N2OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(CSCC2)=C2N=C(C3=CC=C(C(F)(F)F)C=C3)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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XAV-939 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XAV-939 (GMP)284028-89-3PARPpoly ADP ribose polymerasemidbrain dopamine (mDA)neurontankyrasehuman pluripotent stem cells (hPSCs)Inhibitorinhibitorinhibit

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