2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. XAV-939

XAV-939 (GMP) is XAV-939 (HY-15347) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. XAV-939 is a tankyrase inhibitor.

For research use only. We do not sell to patients.

XAV-939 Chemical Structure

XAV-939 Chemical Structure

CAS No. : 284028-89-3

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Based on 1 publication(s) in Google Scholar

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Description

XAV-939 (GMP) is XAV-939 (HY-15347) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. XAV-939 is a tankyrase inhibitor[1].

In Vitro

XAV-939 (GMP) (5 μM; 2 μM for 3 days; 1 μM) induces human pluripotent stem cells (hPSCs) to post-mitotic cortical neurons differentiation[1].
XAV939 (GMP) promotes anterior CNS identity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

XAV-939 Related Antibodies

RT-PCR[1]

Cell Line: Human pluripotent stem cells (hPSCs)
Concentration: 5 μM, 2 μM, 1 μM
Incubation Time: 3 days
Result: Showed downregulation of the pluripotency marker OCT4 and induction of neural and neuronal markers PAX6, FOXG1 and DCX, as well as markers of early born cortical neurons, including TBR1 (preplate, subplate and layer VI) and REELIN, in LSB+X/P/S/D conditions.
Molecular Weight

312.31

Formula

C14H11F3N2OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(CSCC2)=C2N=C(C3=CC=C(C(F)(F)F)C=C3)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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XAV-939 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XAV-939 (GMP)284028-89-3PARPpoly ADP ribose polymerasemidbrain dopamine (mDA)neurontankyrasehuman pluripotent stem cells (hPSCs)Inhibitorinhibitorinhibit

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