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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
human nicotinamide phosphoribosyltransferase
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "human nicotinamide phosphoribosyltransferase" in MCE Product Catalog:
6
6 Cited Publications
Cat. No.: HY-P70353
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NAMPT; Pre-B-Cell Colony-Enhancing Factor 1; Prev. PBEF1; Pre-B-Cell Colony Enhancing Factor 1; Visfatin; 1110035O14Rik; PBEF; Nampt; NAmPRTase; VF; nicotinamide phosphoribosyltransferase; Pre-B Cell-Enhancing Factor
Species:
Human
Source:
E. coli
Synonyms: ZM 242421
CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC50 values in the 1-10 nM range) . CB30865 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-163280
CAS No.: 3011930-28-9
Target:
Research Areas:
JGB-1-155 is a nicotinamide phosphoribosyltransferase (NAMPT) activator and also a reactive oxygen species (ROS) inhibitor. JGB-1-155 binds to NAMPT, thereby enhancing its catalytic activity and increasing intracellular NAD + levels. JGB-1-155 alleviates the elevation of ROS levels induced by various types of damage. JGB-1-155 can be used in research related to neurodegenerative diseases .
Cat. No.: HY-162537
CAS No.: 2484876-99-3
LYP-8 is an intracellular nicotinamide phosphoribosyltransferase (iNAMPT) PROTAC degrader with an IC50 of 0.76 μM. LYP-8 recruits VHL E3 ligase to induce iNAMPT polyubiquitination and proteasome-dependent degradation, and inhibits iNAMPT enzymatic activity. LYP-8 reduces eNAMPT levels by degrading iNAMPT to decrease eNAMPT secretion. LYP-8 reduces intracellular NAD + levels in cancer cells and proinflammatory cytokine levels (IL-6, TNF-α) in tumor tissue and serum. LYP-8 can be used for the research of colon cancer .
Cat. No.: HY-182567
CAS No.: 2109805-79-8
Nampt-IN-19 is an orally active and non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a human Ki of 5.6 nM. Nampt-IN-19 blocks NAD + biosynthesis from Nicotinamide (HY-B0150). Nampt-IN-19 acts as an antiproliferative agent in cancer cells. Nampt-IN-19 has preclinical pharmacokinetic properties supporting oral antitumor activity in mouse xenograft models. Nampt-IN-19 can be used for the research of colorectal cancer .
Cat. No.: HY-189001
PROTEC NAMPT Degrader-1 is a NAMPT PROTEC degrader. PROTEC NAMPT Degrader-1 binds to NAMPT via non-covalent interactions and degrades this protein through a proximity-induced radical oxidation mechanism mediated by cyclopropane radical clock, independent of proteasomal or lysosomal pathways. PROTEC NAMPT Degrader-1 exhibits anticancer activity against ovarian cancer. It can be used in relevant studies on ovarian cancer (Pink: NAMPT ligand: (HY-188123); Linker: (HY-188124)) .
Cat. No.: HY-187360
CAS No.: 3087291-81-1
Target:
Research Areas:
MC-Val-Ala-PAB-NH-Ph-CO-piperidin-4-ol-C4-NH-cyanoguanidine is a cathepsin B-cleavable linker-payload, with Nampt-IN-22 (HY-187336) as its toxin moiety. MC-Val-Ala-PAB-NH-Ph-CO-piperidin-4-ol-C4-NH-cyanoguanidine can be used for the synthesis of ADC .
Cat. No.: HY-184247
CAS No.: 2791469-14-0
Target:
Research Areas:
SR-32685 is a NAMPT activator and neuroprotective agent. SR-32685 enhances the enzymatic activity of hNAMPT, prevents intracellular NAD depletion, and protects neurons from death induced by toxic misfolded prion proteins. SR-32685 can be used in the research of protein misfolding neurodegenerative diseases and metabolic diseases .
Cat. No.: HY-P704014
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NAMPT; Pre-B-Cell Colony-Enhancing Factor 1; Prev. PBEF1; Pre-B-Cell Colony Enhancing Factor 1; Visfatin; 1110035O14Rik; PBEF; Nampt; NAmPRTase; VF; nicotinamide phosphoribosyltransferase; Pre-B Cell-Enhancing Factor
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-184246
CAS No.: 2791469-19-5
Target:
Research Areas:
SR-34831 is a NAMPT activator, NAD level stabilizer and neuroprotective agent. SR-34831 enhances the enzymatic activity of human NAMPT, prevents intracellular NAD depletion, and counteracts neuronal death induced by toxic misfolded prion proteins. SR-34831 exhibits metabolic stability in human liver microsomes and can be used for the research of protein misfolding neurodegenerative diseases .
Cat. No.: HY-181350
Target:
Carbonic Anhydrase NAMPT Apoptosis Reactive Oxygen Species (ROS) ERK Akt DNA/RNA Synthesis Mitochondrial Metabolism
Research Areas:
CAIX/XII/NAMPT-IN-1 is a triple inhibitor of carbonic anhydrase IX/XII and nicotinamide phosphoribosyltransferase (NAMPT) with a hCA IX Ki of 78.1 nM, hCA XII Ki of 64.4 nM, and hNAMPT IC50 of 168 nM. CAIX/XII/NAMPT-IN-1 induces apoptosis, ROS accumulation, suppresses ERK/AKT signaling, inhibits DNA synthesis, and causes mitochondrial dysfunction. CAIX/XII/NAMPT-IN-1 exerts antiproliferative effects against multiple cancer cells under normoxic and hypoxic conditions. CAIX/XII/NAMPT-IN-1 can be used for the research of cancer, such as renal carcinoma, glioblastoma and colorectal cancer .
Cat. No.: HY-184467
CAS No.: 1362150-16-0
Nampt-IN-20 is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor with a IC50 of 9.0 nM. Nampt-IN-20 binds to the active site of Nampt, occupies the NAM-binding region and disrupts NAD biosynthesis. Nampt-IN-20 exerts antiproliferative effects in A2780 ovarian cancer cells. Nampt-IN-20 can be used for the research of ovarian cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
