5 Results for "

lymphocyte depletion

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "lymphocyte depletion" in MCE Product Catalog:

9
9 Cited Publications
Cat. No.: HY-W107464
CAS No.: 2457232-14-1
Target:  

PDI

G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells .
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Cat. No.: HY-P9948
CAS No.: 216503-57-0
Synonyms: Campath-IH

Target:  

Apoptosis

Research Areas:  

Cancer

Alemtuzumab (Campath-IH) is a humanized monoclonal antibody against CD52. Alemtuzumab does not cross-react with murine CD52. Alemtuzumab selectively targets the CD52 antigen to induce profound lymphocyte depletion, followed by recovery of T and B cells with regulatory phenotypes. Alemtuzumab is capable of complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC), as well as induction of apoptosis. Alemtuzumab has the potential for B-cell chronic lymphocytic leukaemia research .
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Cat. No.: HY-P992178

Target:  

NF-κB

Research Areas:  

Cancer

ALLO-647 is a human monoclonal antibody targeting CD52. ALLO-647 transiently and selectively depletes host lymphocytes to promote the proliferation of allogeneic CAR T-cell following infusion. ALLO-647 can be used for the research of B-cell lymphoma and follicular lymphoma .
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Cat. No.: HY-W107464R
CAS No.: 2457232-14-1
G6PDi-1 (Standard) is the analytical standard of G6PDi-1 (HY-W107464). This product is intended for research and analytical applications. G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytoKine production in T cells .
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Cat. No.: HY-N20639
CAS No.: 464-71-1
Synonyms: 3-Deoxycaryoptinol
Clerodin (3-Deoxycaryoptinol) is a natural diterpenoid compound that can be isolated from traditional Chinese medicinal plants such as Clerodendrum infortunatum. Clerodin exhibits caspase-3 regulation, apoptosis induction, cell cycle arrest, ROS induction and glutathione depletion effects, along with anti-cancer and antifeedant activities. It shows selective cytotoxicity against leukemia cells and breast cancer cells, but has no obvious toxicity to normal human blood cells and lymphocytes. Clerodin also reduces the feeding behavior of Helicoverpa armigera larvae on cabbage leaf discs, but has no significant contact toxicity to these larvae. Clerodin can be used in research related to acute monocytic leukemia and human breast cancer .
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