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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
38 Results for "
lysosomal cathepsin
" in MedChemExpress (MCE) Product Catalog:
Products (38)
38 Results for "lysosomal cathepsin" in MCE Product Catalog:
8
8 Publications Verification
Cat. No.: HY-16594
CAS No.: 133343-34-7
Category:
Target:
1
Target:
Research Areas:
Cathepsin D (CTSD) is a lysosomal aspartic protease encoded by the CTSD gene. Cathepsin D regulates lysosomal protease activity. Loss of Cathepsin D leads to lysosomal dysfunction and the accumulation of various cellular proteins associated with neurodegenerative diseases. Cathepsin D is involved in breast cancer metastasis. Cathepsin D can be used in research on diseases such as breast cancer and stroke .
1
1 Cited Publications
Cat. No.: HY-P72155
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CTSD; cathepsin D (lysosomal Aspartyl Protease); Prev. CPSD; lysosomal Aspartyl Protease; CLN10; cathepsin D Isoform 2; Ceroid-Lipofuscinosis, Neuronal 10; HEL-S-130P; Epididymis Secretory Sperm Binding Protein Li 130P; cathepsin D; lysosomal Aspartyl Pep
Species:
Others
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P7748A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTSD; cathepsin D (lysosomal Aspartyl Protease); Prev. CPSD; lysosomal Aspartyl Protease; CLN10; cathepsin D Isoform 2; Ceroid-Lipofuscinosis, Neuronal 10; HEL-S-130P; Epididymis Secretory Sperm Binding Protein Li 130P; cathepsin D; lysosomal Aspartyl Pep
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P7748
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTSD; cathepsin D (lysosomal Aspartyl Protease); Prev. CPSD; lysosomal Aspartyl Protease; CLN10; cathepsin D Isoform 2; Ceroid-Lipofuscinosis, Neuronal 10; HEL-S-130P; Epididymis Secretory Sperm Binding Protein Li 130P; cathepsin D; lysosomal Aspartyl Pep
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P7758
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTSZ; cathepsin IV; cathepsin Z; cathepsin B2; cathepsin X; cathepsin Z1; CTSX; cathepsin Y; Cysteine-Type Carboxypeptidase; cathepsin P; lysosomal Carboxypeptidase B; Preprocathepsin P; Carboxypeptidase LB
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P7745
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTSA; PPCA; Prev. PPGB; Protective Protein For Beta-Galactosidase; Prev. GSL; Beta-Galactosidase Protective Protein; lysosomal Protective Protein; Alternative Protein CTSA; Carboxypeptidase C; Beta-Galactosidase 2; Carboxypeptidase Y-Like Kininase; Carbox
Species:
Human
Source:
HEK293
Cat. No.: HY-W011063
CAS No.: 21438-66-4
Target:
Research Areas:
Gly-Phe-β-naphthylamide is a substrate of Cathepsin C (HY-P2922) and belongs to the lysosomal agonist. Gly-Phe-β-naphthylamide can freely pass through the cell membrane and organelle membrane. Gly-Phe-β-naphthylamide will be specifically hydrolyzed by Cathepsin C, ultimately leading to a permeability lysis when it enters the acidic compartment. Gly-Phe-β-naphthylamide can be used to study lysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C .
Cat. No.: HY-164729
Cat. No.: HY-P1759
CAS No.: 65147-22-0
Synonyms: Z-FR-AMC
Cat. No.: HY-42709
CAS No.: 24787-89-1
Synonyms: Carbobenzoxy-L-valyl-L-alanine
Target:
Research Areas:
Cat. No.: HY-P1759A
CAS No.: 70382-26-2
Synonyms: Z-FR-AMC hydrochloride
Cathepsin C is a lysosomal cysteine protease essential for catalytic activation of many serine proteases, including proteinase 3 (PR3), neutrophil elastase (NE), cathepsin G (CTSG), granzyme A/B/C, and mast cell chymase .
Research Areas:
p-Toluenesulfonamide is a small-molecule anticancer agent and plasticizer. p-Toluenesulfonamide exerts antitumor activity by inducing lysosomal membrane permeabilization, cathepsin B release and lysosome-mediated cell death. p-Toluenesulfonamide modulates cholesterol distribution in lipid rafts of tumor cell membranes and the Akt/mTOR/p70S6K pathway. p-Toluenesulfonamide shows activity against various cancers including hepatocellular carcinoma, non-small cell lung cancer and tongue squamous cell carcinoma; intrapleural injection effectively reduces malignant pleural effusion without causing pleural adhesion. p-Toluenesulfonamide is also the main degradation product of the disinfectant Chloramine-T (HY-B0959) in water. p-Toluenesulfonamide facilitates the localization of fluorescent probes to the endoplasmic reticulum. p-Toluenesulfonamide can be used in cancer-related research .
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Research Areas:
Phe-Lys(Trt)-PAB is a cathepsin B substrate, and a cleavable ADC linker. Phe-Lys(Trt)-PAB acts as a lysosomally cleavable substrate for cysteine protease cathepsin B, with cleavage enabling linked anticancer drug release via self-immolative spacer . Phe-Lys(Trt)-PAB can be used for synthesis of ADCs .
Target:
Cat. No.: HY-12733
CAS No.: 1254318-44-9
Target:
Research Areas:
AZD5248 is an orally active, selective dipeptidyl peptidase 1 (cathepsin C) inhibitor, with IC50 values of 1 nM and 17 nM against human CatC, 44 nM against human DPP1, and 67 nM against rat DPP1. It exhibits low clearance and high bioavailability in animal models. AZD5248 forms an irreversible covalent bond with the catalytic Cys234 residue of CatC, exerts reversible inhibition via its nitrile moiety, blocks CatC-dependent amyloid formation, and reduces the activation levels of neutrophil serine proteases in bone marrow and blood. AZD5248 reacts with aortic elastin aldehydes to form stable 4-imidazolinones, induces ultrastructural changes in aortic tissue, and has an α-amino acid-based backbone. AZD5248 reduces the severity of acute pancreatitis in mouse models. AZD5248 can be used in research on chronic obstructive pulmonary disease, acute pancreatitis, neurodegenerative diseases, lysosomal storage disorders, acute lung injury, cystic fibrosis, and neutrophil-mediated inflammatory diseases .
Cat. No.: HY-P4295
CAS No.: 71732-53-1
Synonyms: PADK
Target:
Research Areas:
Cat. No.: HY-79602S1
CAS No.: 287476-18-0
Research Areas:
p-Toluenesulfonamide- 15N is the 15N-labeled p-Toluenesulfonamide (HY-79602). p-Toluenesulfonamide is a small-molecule anticancer agent and plasticizer. p-Toluenesulfonamide exerts antitumor activity by inducing lysosomal membrane permeabilization, cathepsin B release and lysosome-mediated cell death. p-Toluenesulfonamide modulates cholesterol distribution in lipid rafts of tumor cell membranes and the Akt/mTOR/p70S6K pathway. p-Toluenesulfonamide shows activity against various cancers including hepatocellular carcinoma, non-small cell lung cancer and tongue squamous cell carcinoma; intrapleural injection effectively reduces malignant pleural effusion without causing pleural adhesion. p-Toluenesulfonamide is also the main degradation product of the disinfectant Chloramine-T (HY-B0959) in water. p-Toluenesulfonamide facilitates the localization of fluorescent probes to the endoplasmic reticulum. p-Toluenesulfonamide can be used in cancer-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
