70-55-3
70-55-3
Chemical Structure
p-Toluenesulfonamide
- CAS No.: 70-55-3
- Formula:C7H9NO2S
- Molecular Weight:171.22
IUPAC Name: 4-methylbenzenesulfonamide
InChIKey: LMYRWZFENFIFIT-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C)C=C1)(N)=O
Biological Activity: p-Toluenesulfonamide is a small-molecule anticancer agent and plasticizer. p-Toluenesulfonamide exerts antitumor activity by inducing lysosomal membrane permeabilization, cathepsin B release and lysosome-mediated cell death. p-Toluenesulfonamide modulates cholesterol distribution in lipid rafts of tumor cell membranes and the Akt/mTOR/p70S6K pathway. p-Toluenesulfonamide shows activity against various cancers including hepatocellular carcinoma, non-small cell lung cancer and tongue squamous cell carcinoma; intrapleural injection effectively reduces malignant pleural effusion without causing pleural adhesion. p-Toluenesulfonamide is also the main degradation product of the disinfectant Chloramine-T (HY-B0959) in water. p-Toluenesulfonamide facilitates the localization of fluorescent probes to the endoplasmic reticulum. p-Toluenesulfonamide can be used in cancer-related research[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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p-Toluenesulfonamide | 99.98% | p-Toluenesulfonamide is a small-molecule anticancer agent and plasticizer. p-Toluenesulfonamide exerts antitumor activity by inducing lysosomal membrane permeabilization, cathepsin B release and lysosome-mediated cell death. p-Toluenesulfonamide modulates cholesterol distribution in lipid rafts of tumor cell membranes and the Akt/mTOR/p70S6K pathway. p-Toluenesulfonamide shows activity against various cancers including hepatocellular carcinoma, non-small cell lung cancer and tongue squamous cell carcinoma; intrapleural injection effectively reduces malignant pleural effusion without causing pleural adhesion. p-Toluenesulfonamide is also the main degradation product of the disinfectant Chloramine-T (HY-B0959) in water. p-Toluenesulfonamide facilitates the localization of fluorescent probes to the endoplasmic reticulum. p-Toluenesulfonamide can be used in cancer-related research. | ||||||||||||||||||||
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p-Toluenesulfonamide (Standard) | ≥98% | p-Toluenesulfonamide (Standard) is the analytical standard of p-Toluenesulfonamide (HY-79602). This product is intended for research and analytical applications. p-Toluenesulfonamide is a small-molecule anticancer agent and plasticizer. p-Toluenesulfonamide exerts antitumor activity by inducing lysosomal membrane permeabilization, cathepsin B release and lysosome-mediated cell death. p-Toluenesulfonamide modulates cholesterol distribution in lipid rafts of tumor cell membranes and the Akt/mTOR/p70S6K pathway. p-Toluenesulfonamide shows activity against various cancers including hepatocellular carcinoma, non-small cell lung cancer and tongue squamous cell carcinoma; intrapleural injection effectively reduces malignant pleural effusion without causing pleural adhesion. p-Toluenesulfonamide is also the main degradation product of the disinfectant Chloramine-T (HY-B0959) in water. p-Toluenesulfonamide facilitates the localization of fluorescent probes to the endoplasmic reticulum. p-Toluenesulfonamide can be used in cancer-related research. | ||||||||||||||||||||
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p-Toluenesulfonamide-15N | p-Toluenesulfonamide-15N is the 15N-labeled p-Toluenesulfonamide (HY-79602). p-Toluenesulfonamide is a small-molecule anticancer agent and plasticizer. p-Toluenesulfonamide exerts antitumor activity by inducing lysosomal membrane permeabilization, cathepsin B release and lysosome-mediated cell death. p-Toluenesulfonamide modulates cholesterol distribution in lipid rafts of tumor cell membranes and the Akt/mTOR/p70S6K pathway. p-Toluenesulfonamide shows activity against various cancers including hepatocellular carcinoma, non-small cell lung cancer and tongue squamous cell carcinoma; intrapleural injection effectively reduces malignant pleural effusion without causing pleural adhesion. p-Toluenesulfonamide is also the main degradation product of the disinfectant Chloramine-T (HY-B0959) in water. p-Toluenesulfonamide facilitates the localization of fluorescent probes to the endoplasmic reticulum. p-Toluenesulfonamide can be used in cancer-related research. | |||||||||||||||||||||
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4-Tolyl-sulfonamide-d4 | 4-Tolyl-d4-sulfonamide (p-Tosylamide-d4) is the d4-labeled p-Toluenesulfonamide (HY-79602). p-Toluenesulfonamide is a small-molecule anticancer agent and plasticizer. p-Toluenesulfonamide exerts antitumor activity by inducing lysosomal membrane permeabilization, cathepsin B release and lysosome-mediated cell death. p-Toluenesulfonamide modulates cholesterol distribution in lipid rafts of tumor cell membranes and the Akt/mTOR/p70S6K pathway. p-Toluenesulfonamide shows activity against various cancers including hepatocellular carcinoma, non-small cell lung cancer and tongue squamous cell carcinoma; intrapleural injection effectively reduces malignant pleural effusion without causing pleural adhesion. p-Toluenesulfonamide is also the main degradation product of the disinfectant Chloramine-T (HY-B0959) in water. p-Toluenesulfonamide facilitates the localization of fluorescent probes to the endoplasmic reticulum. p-Toluenesulfonamide can be used in cancer-related research. | |||||||||||||||||||||
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4-tert-Butylbenzenesulfonamide (Standard) | ≥98% | 4-tert-Butylbenzenesulfonamide (Standard) is the analytical standard of 4-tert-Butylbenzenesulfonamide. This product is intended for research and analytical applications. | ||||||||||||||||||||
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p-Sulfamoylbenzaldehyde (Standard) | ≥98% | p-Sulfamoylbenzaldehyde (Standard) is the analytical standard of p-Sulfamoylbenzaldehyde. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Sulfanilamide | 99.90% | ulfanilamide (Sulphanilamide) is a potent and orally active sulfonamide antibiotic and can be a major intermediate of sulfamethoxazole biodegradation. Sulfanilamide also is a carbonic anhydrase inhibitor. Sulfanilamide shows inhibition on virus of lymphogranuloma venereum. | ||||||||||||||||||||
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Mafenide | 99.96% | Mafenide is a potent sulfonamide antimicrobial agent. Mafenide exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Mafenide also exhibits antifungal activity against filamentous fungi (e.g., Lichtheimia and Aspergillus flavus). Mafenide can be used in the research of skin grafts on burn wounds, post-traumatic invasive fungal infections, and bacterially contaminated wounds. | ||||||||||||||||||||
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2-Methylbenzenesulfonamide (Standard) | ≥98% | 2-Methylbenzenesulfonamide (Standard) is the analytical standard of 2-Methylbenzenesulfonamide. This product is intended for research and analytical applications. | ||||||||||||||||||||
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p-Toluenesulfonic acid monohydrate (Standard) | 99.70% | p-Toluenesulfonic acid (monohydrate) (Standard) is the analytical standard of p-Toluenesulfonic acid (monohydrate). This product is intended for research and analytical applications. p-Toluenesulfonic acid monohydrate, a strong organic acid, acts as organic catalyst used in organic synthesis . | ||||||||||||||||||||
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Potassium p-toluenethiosulfonate, 98% | Potassium p-toluenethiosulfonate, 98% is a conjugate. | |||||||||||||||||||||
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Methyl 4-methylbenzenesulfonate (Standard) | ≥98% | Methyl 4-methylbenzenesulfonate (Standard) is the analytical standard of Methyl 4-methylbenzenesulfonate. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Methyl 4-methylbenzenesulfonate-13C | Methyl 4-methylbenzenesulfonate-13C is the 13C-labeled Methyl 4-methylbenzenesulfonate. | |||||||||||||||||||||
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References
- [1]. Luo YH, et al. A novel agent, p-toluenesulfonamide, in the management of malignant pleural effusions. Lung Cancer. 2025 Dec;210:108814.
- [2]. National Toxicology Program. Toxicity studies of p-toluenesulfonamide administered in feed to F344/N rats, F344/NTac rats, and B6C3F1/N mice. Toxic Rep Ser. 2016 Aug;(88):NTP-TOX-88.
- [3]. Tian YM, et al. A p-toluenesulfonamide-modified benzo[h]chromene hydrazone: Fluorescent turn-on detection of hypochlorite and its application to imaging the endoplasmic reticula of living cells and zebrafishes. Spectrochim Acta A Mol Biomol Spectrosc. 2023 Aug 5;296:122669. [Content Brief]
- [4]. Ajibola A, et al. Benzosulfonamides in wastewater: method development, occurrence and removal efficiencies. Chemosphere. 2015 Jan;119 Suppl:S21-7. [Content Brief]
