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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
matrix metalloproteinase-13
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "matrix metalloproteinase-13" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
T-26c, a chemical probe, is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes .
1
1 Cited Publications
Cat. No.: HY-P702527
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MMP13; MMP-13; matrix Metallopeptidase 13; matrix metalloproteinase 13; Collagenase 3; Alternative Protein MMP13; CLG3; MANDP1; matrix metalloproteinase 13 (Collagenase 3); MDST; matrix metalloproteinase-13
Species:
Human
Source:
HEK293
Cat. No.: HY-N2503
CAS No.: 181225-33-2
Cat. No.: HY-120505
CAS No.: 1180532-17-5
Research Areas:
ITZ-1 is an orally active and selective extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) pathway inhibitor with an IC50 of 0.51 μM for inhibiting interleukin-1β (IL-1β)-induced matrix metalloproteinase-13 (MMP-13) production. ITZ-1 reduces MMP-13 expression and suppresses nitric oxide (NO)-induced chondrocyte apoptosi. ITZ-1 is promising for research of osteoarticular diseases .
Cat. No.: HY-107640
CAS No.: 307002-73-9
WAY-170523 is a potent and selective MMP-13 (matrix metalloproteinase-13) inhibitor, with an IC50 of 17 nM. WAY-170523 can directly attenuate ERK1/2 phosphorylation. WAY-170523 inhibits the invasion of PC-3 cells, can be used for prostate cancer research .
Cat. No.: HY-107013
CAS No.: 230954-09-3
Target:
Research Areas:
CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM .
Cat. No.: HY-P701987
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MMP13; MMP-13; matrix Metallopeptidase 13; matrix metalloproteinase 13; Collagenase 3; Alternative Protein MMP13; CLG3; MANDP1; matrix metalloproteinase 13 (Collagenase 3); MDST; matrix metalloproteinase-13
Species:
Human
Source:
E. coli
Cat. No.: HY-162902
CAS No.: 3001361-04-9
Target:
Research Areas:
ALK5-IN-82 is a potent and selective inhibitor against activin receptor-like kinase 5 (ALK5) with an IC50 value of 9.1 nM. ALK5-IN-82 inhibits the protein expression of α-smooth muscle actin (α-SMA), collagen I and tissue inhibitor of metalloproteinase 1 (TIMP-1)/matrix metalloproteinase 13 (MMP-13) in transforming growth factor-β-induced human umbilical vein endothelial cells. ALK5-IN-82 is promising for research of cardiac fibrosis .
Cat. No.: HY-100518R
CAS No.: 869296-13-9
Target:
Research Areas:
T-26c (Standard) is the analytical standard of T-26c (HY-100518). This product is intended for research and analytical applications. T-26c, a chemical probe, is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes .
Cat. No.: HY-119138
CAS No.: 321344-32-5
Target:
Research Areas:
R-130823 is an orally active, highly selective p38α inhibitor with an IC50 of 22 nM against p38α, an IC50 of 820 nM against p38β, and no activity against p38γ or p38δ. R-130823 downregulates downstream cartilage degradation and inflammatory mediators, and inhibits the release of MMP-13, MMP-1 and PGE2. R-130823 reduces hind paw swelling, improves hyperalgesia, and blocks arthritis progression. R-130823 is applicable to research related to osteoarthritis and rheumatoid arthritis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
