7 Results for "

mouse BMMs

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "mouse BMMs" in MCE Product Catalog:

3
Icariside I
Icariside I
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3 Cited Publications
Cat. No.: HY-N1939
CAS No.: 56725-99-6
Synonyms: Icarisid I
Category:  

Flavonols Flavonoids Monophenols Other Diseases Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields

Target:  

Apoptosis Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) STAT CDK Bcl-2 Family Aryl Hydrocarbon Receptor JAK Caspase IFNAR PD-1/PD-L1

Icariside I (GH01) is an orally active metabolite of icalin. Icariside I improves estrogen deficiency-induced osteoporosis by simultaneously regulating osteoblast and osteoclast differentiation. Icariside I promotes ATP (HY-B2176) or Nigericin (HY-127019)-induced mtROS production and NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Icariside I does not alter the activation of NLRC4 and AIM2 inflammasomes. Icariside I inhibits breast cancer proliferation, apoptosis, invasion, and metastasis by targeting the IL-6/STAT3 pathway. Icariside I is a kynurenine-AhR pathway inhibitor that alleviates cancer by blocking tumor immune escape .
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2
Vaccarin
Vaccarin
0 Images
2 Cited Publications
Cat. No.: HY-N1419
CAS No.: 53452-16-7
Category:  

other families Flavonoids Flavones Metabolic Disease Phenols Polyphenols Plants Disease Research Fields

Target:  

AMPK Akt ERK p38 MAPK NF-κB Nuclear Factor of activated T Cells (NFAT) JNK

Vaccarin is an orally active flavonoid glycoside with multiple biological functions. Vaccarin promotes neovascularization by activating AKT and ERK. Vaccarin activates the AMPK signaling pathway to improve insulin resistance and steatosis. Vaccarin is a MAPK, NF-κB, and NFAT inhibitor, effectively blocking RANKL-induced osteoclastogenesis .
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2
Bropirimine
Bropirimine
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2 Cited Publications
Cat. No.: HY-W008634
CAS No.: 56741-95-8
Synonyms: U-54461; U-54461S; PNU-54461
Target:  

Toll-like Receptor (TLR)

Research Areas:  

Cancer

Bropirimine (U-54461; U-54461S; PNU-54461) is an orally active TLR7 agonist. Bropirimine inhibits RANKL-induced osteoclast differentiation of mouse bone marrow-derived macrophages (BMMs). Bropirimine exhibits dose-dependent direct inhibitory effects on colony formation of cultured KK-47 and 724 cells. Bropirimine can be used for the study of cancers and bone metabolic disorders such as osteoporosis .
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2
Usnic acid
Usnic acid
0 Images
2 Cited Publications
Cat. No.: HY-N0656
CAS No.: 125-46-2
Category:  

Natural Products Plants Infection Usnea diffracta Vain. Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Usneaceae

Target:  

Bacterial DNA/RNA Synthesis Nuclear Factor of activated T Cells (NFAT) Apoptosis

Usnic acid is a secondary metabolite of lichens with a unique dibenzofuran skeleton. Usnic acid inhibits DNA/RNA synthesis and has antibacterial activity. Usnic acid induces cell cycle arrest and apoptosis and has anticancer activity. Usnic acid inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1. Usnic acid has antioxidant and anti-inflammatory activities by inhibiting lipid peroxidation and myeloperoxidase .
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Usnic acid (Standard)
Usnic acid (Standard)
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Cat. No.: HY-N0656R
CAS No.: 125-46-2
Category:  

Natural Products Usnea diffracta Vain. Phenols Polyphenols Plants Usneaceae

Target:  

Reference Standards Bacterial DNA/RNA Synthesis Nuclear Factor of activated T Cells (NFAT) Apoptosis

Usnic acid is a secondary metabolite of lichens with a unique dibenzofuran skeleton. Usnic acid inhibits DNA/RNA synthesis and has antibacterial activity. Usnic acid induces cell cycle arrest and apoptosis and has anticancer activity. Usnic acid inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1. Usnic acid has antioxidant and anti-inflammatory activities by inhibiting lipid peroxidation and myeloperoxidase .
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Icariside I (Standard)
Icariside I (Standard)
0 Images
Cat. No.: HY-N1939R
CAS No.: 56725-99-6
Synonyms: Icarisid I (Standard)
Category:  

Flavonols Flavonoids Monophenols Phenols Epimedium brevicornu Maxim. Plants Berberidaceae

Target:  

Reference Standards Apoptosis Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) STAT CDK Bcl-2 Family Aryl Hydrocarbon Receptor JAK Caspase IFNAR PD-1/PD-L1

Icariside I (Standard) is the analytical standard of Icariside I (HY-N1939). This product is intended for research and analytical applications. Icariside I (GH01) is an orally active metabolite of icalin. Icariside I improves estrogen deficiency-induced osteoporosis by simultaneously regulating osteoblast and osteoclast differentiation. Icariside I promotes ATP (HY-B2176) or Nigericin (HY-127019)-induced mtROS production and NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Icariside I does not alter the activation of NLRC4 and AIM2 inflammasomes. Icariside I inhibits breast cancer proliferation, apoptosis, invasion, and metastasis by targeting the IL-6/STAT3 pathway. Icariside I is a kynurenine-AhR pathway inhibitor that alleviates cancer by blocking tumor immune escape .
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SH494
SH494
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Cat. No.: HY-182818
Target:  

p38 MAPK Keap1-Nrf2 Reactive Oxygen Species (ROS)

Research Areas:  

Metabolic Disease

SH494 is a p38 MAPK inhibitor and Nrf2 pathway activator. SH494 inhibits RANKL-induced phosphorylation of p38 and disrupts the MAPK cascade associated with osteoclastogenesis. SH494 activates the Nrf2 pathway, upregulates downstream target genes and induces the expression of cytoprotective enzymes. SH494 reduces intracellular ROS accumulation and restores mitochondrial membrane potential (ΔΨm) to normal. SH494 decreases osteoclast activity and alleviates osteoporosis symptoms in ovariectomized mice. SH494 can be used for research on osteoporosis .
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