564 Results for "

nitric+oxide

" in MedChemExpress (MCE) Product Catalog:
Products (564)

564 Results for "nitric+oxide" in MCE Product Catalog:

39
Midostaurin
Midostaurin
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39 Publications Verification
Cat. No.: HY-10230
CAS No.: 120685-11-2
Purity:  99.91%
Synonyms: PKC412; CGP 41251
Target:  

PKC VEGFR c-Kit NO Synthase Apoptosis

Research Areas:  

Cancer

Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .
29
1400W Dihydrochloride
1400W Dihydrochloride
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29 Cited Publications
Cat. No.: HY-18731
CAS No.: 214358-33-5
Target:  

NO Synthase Apoptosis

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .
29
1400W
1400W
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29 Cited Publications
Cat. No.: HY-18730
CAS No.: 180001-34-7
Synonyms: W1400
Target:  

NO Synthase Apoptosis

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .
29
Methylene Blue
Methylene Blue
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29 Cited Publications
Cat. No.: HY-14536
CAS No.: 61-73-4
Purity:  95.05%
Synonyms: Basic Blue 9; CI-52015; Methylthioninium chloride
Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene Blue is a photosensitizer and redox agent. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .
26
Omaveloxolone
Omaveloxolone
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26 Cited Publications
Cat. No.: HY-12212
CAS No.: 1474034-05-3
Purity:  99.38%
Synonyms: RTA 408
Target:  

Keap1-Nrf2 STING Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Omaveloxolone (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.
26
Methylene blue hydrate
Methylene blue hydrate
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26 Cited Publications
Cat. No.: HY-D0958
CAS No.: 122965-43-9
Synonyms: Basic Blue 9 hydrate; CI-52015 hydrate; Methylthioninium chloride hydrate
Target:  

Guanylate Cyclase Monoamine Oxidase NO Synthase Microtubule/Tubulin

Research Areas:  

Infection Inflammation/Immunology Cancer

Methylene blue (Basic Blue 9) hydrate is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue hydrate through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue hydrate is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue hydrate is a Tau aggregation inhibitor. Methylene blue hydrate reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .
23
L-Arginine
L-Arginine
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23 Cited Publications
Cat. No.: HY-N0455
CAS No.: 74-79-3
Category:  

Cardiovascular Disease Amino acids Endogenous metabolite Disease Research Fields Cancer

Target:  

Environmental Pollutants Endogenous Metabolite NO Synthase Ligands for E3 Ligase

L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .
23
L-Arginine hydrochloride
L-Arginine hydrochloride
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23 Cited Publications
Cat. No.: HY-N0455A
CAS No.: 1119-34-2
Synonyms: (S)-(+)-Arginine hydrochloride
Category:  

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

NO Synthase Endogenous Metabolite

L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .
23
L-Arginine (L-glutamate)
L-Arginine (L-glutamate)
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23 Cited Publications
Cat. No.: HY-N0455B
CAS No.: 4320-30-3
Synonyms: (S)-(+)-Arginine (L-glutamate)
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Endogenous Metabolite NO Synthase

L-Arginine L-glutamate ((S)-(+)-Arginine L-glutamate) is the nitrogen donor for synthesis of nitric oxide. L-Arginine L-glutamate can be used for upper gastrointestinal hypofunction or dysfunction like functional dyspepsia research .
22
Ibuprofen sodium
Ibuprofen sodium
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22 Cited Publications
Cat. No.: HY-78131C
CAS No.: 31121-93-4
Synonyms: (±)-Ibuprofen sodium
Target:  

COX Apoptosis Parasite

Research Areas:  

Infection Neurological Disease Inflammation/Immunology Cancer

Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .
22
Ibuprofen
Ibuprofen
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22 Cited Publications
Cat. No.: HY-78131
CAS No.: 15687-27-1
Synonyms: (±)-Ibuprofen
Target:  

COX Apoptosis Parasite

Research Areas:  

Infection Neurological Disease Inflammation/Immunology Cancer

Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .
22
Ibuprofen L-lysine
Ibuprofen L-lysine
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22 Cited Publications
Cat. No.: HY-100586
CAS No.: 57469-77-9
Purity:  99.91%
Synonyms: (±)-Ibuprofen L-lysine
Target:  

COX Apoptosis Parasite

Research Areas:  

Infection Inflammation/Immunology Cancer

Ibuprofen ((±)-Ibuprofen) L-lysine is a potent orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen L-lysine inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen L-lysine is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen L-lysine can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .
18
Paroxetine
Paroxetine
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18 Cited Publications
Cat. No.: HY-122272
CAS No.: 61869-08-7
Purity:  99.92%
Synonyms: BRL29060
Target:  

Cytochrome P450 5-HT Receptor NO Synthase Apoptosis Serotonin Transporter Estrogen Receptor/ERR

Paroxetine (BRL29060) is an orally active and selective serotonin reuptake inhibitor (SSRI) and apoptosis inducer with blood-brain barrier permeability. Paroxetine inhibits nitric oxide synthase and CYP2D6, induces desensitization of 5-HT1A/1B/1D autoreceptors, downregulates 5-HT2 receptors, and promotes the production of inflammatory cytokines. Paroxetine is a weak norepinephrine (NE) uptake inhibitor and possesses antitumor activity. Paroxetine is widely used in research concerning depression, obsessive-compulsive disorder, panic disorder, social phobia, generalized anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, hot flashes, and related conditions .
18
Paroxetine hydrochloride
Paroxetine hydrochloride
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18 Cited Publications
Cat. No.: HY-B0492
CAS No.: 78246-49-8
Synonyms: BRL29060 hydrochloride; BRL29060A
Target:  

Cytochrome P450 5-HT Receptor NO Synthase Apoptosis Serotonin Transporter Estrogen Receptor/ERR

Paroxetine (BRL29060) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI) and apoptosis inducer with blood-brain barrier permeability. Paroxetine hydrochloride inhibits nitric oxide synthase and CYP2D6, induces desensitization of 5-HT1A/1B/1D autoreceptors, downregulates 5-HT2 receptors, and promotes the production of inflammatory cytokines. Paroxetine hydrochloride is a weak norepinephrine (NE) uptake inhibitor and possesses antitumor activity. Paroxetine hydrochloride is widely used in research concerning depression, obsessive-compulsive disorder, panic disorder, social phobia, generalized anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, hot flashes, and related conditions .
17
Nitroprusside disodium dihydrate
Nitroprusside disodium dihydrate
0 Images
17 Cited Publications
Cat. No.: HY-A0119
CAS No.: 13755-38-9
Synonyms: Sodium nitroprusside dihydrate; Sodium Nitroferricyanide(III) Dihydrate
Target:  

Autophagy

Research Areas:  

Cardiovascular Disease Cancer

Nitroprusside disodium dehydrate (Sodium nitroprusside dihydrate) is a vasodilator that available for the research of acute hypertension, heart failure. Nitroprusside disodium dehydrate induces autophagy in glutathione-depleted osteoblasts. Nitroprusside disodium dehydrate acts as a nitric oxide (NO) donor in a rat intestinal ischemia reperfusion model .
17
Talfirastide acetate
Talfirastide acetate
0 Images
17 Cited Publications
Cat. No.: HY-12403A
CAS No.: 2855063-75-9
Purity:  99.87%
Synonyms: TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology Endocrinology

Target:  

Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite

Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium .
17
Talfirastide
Talfirastide
0 Images
17 Cited Publications
Cat. No.: HY-12403
CAS No.: 51833-78-4
Purity:  99.75%
Synonyms: TXA127; Angiotensin (1-7); Ang-(1-7)
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite

Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .
14
DAF-FM DA
DAF-FM DA
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14 Cited Publications
Cat. No.: HY-D0717
CAS No.: 254109-22-3
Synonyms: Diaminofluorescein-FM diacetate
DAF-FM DA (Diaminofluorescein-FM diacetate) is a fluorescent probe for the detection and bioimaging of nitric oxide (NO). DAF-FM DA spontaneously crosses the plasma membrane and is subsequently cleaved by esterases to generate intracellular DAF-FM (Ex/Em=495/515 nm) .
13
Tempo
Tempo
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13 Cited Publications
Cat. No.: HY-W001187
CAS No.: 2564-83-2
Target:  

Mitochondrial Metabolism DNA/RNA Synthesis Reactive Oxygen Species (ROS)

Research Areas:  

Cancer

Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells .
11
ODQ
ODQ
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11 Cited Publications
Cat. No.: HY-101255
CAS No.: 41443-28-1
Purity:  99.75%
Target:  

Guanylate Cyclase Apoptosis

Research Areas:  

Cancer

ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells .
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