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Results for "

parasites

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA synthetase (1) Akt (5) Aminoacyl-tRNA Synthetase (1) Aminopeptidase (1) AMPK (2) Antibiotic (43) Antifolate (3) Apoptosis (24) Autophagy (14) Bacterial (34) Bcl-2 Family (4) BCRP (3) Calcium Channel (1) CaMK (2) Caspase (4) Cathepsin (3) Chloride Channel (2) Cytochrome P450 (6) Dengue Virus (5) Dihydrofolate reductase (DHFR) (5) Dihydroorotate Dehydrogenase (8) DNA Methyltransferase (3) DNA/RNA Synthesis (2) Drug Metabolite (6) EGFR (2) Elastase (1) Endogenous Metabolite (8) Environmental Pollutants (4) Flavivirus (5) Fluorescent Dye (1) Fungal (15) Glucosylceramide Synthase (GCS) (1) GLUT (2) GSK-3 (1) Guanylate Cyclase (1) HBV (1) HCV (1) HDAC (4) Herbicide (2) HIF/HIF Prolyl-Hydroxylase (2) Histone Methyltransferase (1) HIV (2) HSP (1) HSV (1) Huntingtin (2) IKK (1) Influenza Virus (2) Interleukin Related (1) Isotope-Labeled Compounds (14) MDM-2/p53 (2) Microtubule/Tubulin (7) Mitochondrial Metabolism (2) Mitophagy (1) MOFs (1) mTOR (4) N-myristoyltransferase (1) Na+/K+ ATPase (3) nAChR (6) Necroptosis (2) NF-κB (3) Nucleoside Antimetabolite/Analog (2) P-glycoprotein (3) p38 MAPK (2) Paraptosis (2) Parasite (324) PARP (4) PDGFR (1) Phosphatase (10) Phosphodiesterase (PDE) (3) Phytohormone (2) PI3K (3) PI4K (3) PKA (4) PKC (2) Potassium Channel (4) PROTACs (1) Proteasome (4) PTEN (2) Pyroptosis (2) RAD51 (2) Reactive Oxygen Species (ROS) (15) Reference Standards (34) SARS-CoV (3) Ser/Thr Kinase (1) STAT (3) Succinate Dehydrogenase (1) TMV (1) Topoisomerase (2) Transmembrane Glycoprotein (1) TrxR (1) VEGFR (2)
By Research Areas:	Cancer (45) Cardiovascular Disease (3) Endocrinology (1) Infection (327) Inflammation/Immunology (26) Metabolic Disease (9) Neurological Disease (7)

By Targets:

Acetyl-CoA synthetase (1)

Akt (5)

Aminoacyl-tRNA Synthetase (1)

Aminopeptidase (1)

AMPK (2)

Antibiotic (43)

Antifolate (3)

Apoptosis (24)

Autophagy (14)

Bacterial (34)

Bcl-2 Family (4)

BCRP (3)

Calcium Channel (1)

CaMK (2)

Caspase (4)

Cathepsin (3)

Chloride Channel (2)

Cytochrome P450 (6)

Dengue Virus (5)

Dihydrofolate reductase (DHFR) (5)

Dihydroorotate Dehydrogenase (8)

DNA Methyltransferase (3)

DNA/RNA Synthesis (2)

Drug Metabolite (6)

EGFR (2)

Elastase (1)

Endogenous Metabolite (8)

Environmental Pollutants (4)

Flavivirus (5)

Fluorescent Dye (1)

Fungal (15)

Glucosylceramide Synthase (GCS) (1)

GLUT (2)

GSK-3 (1)

Guanylate Cyclase (1)

HBV (1)

HCV (1)

HDAC (4)

Herbicide (2)

HIF/HIF Prolyl-Hydroxylase (2)

Histone Methyltransferase (1)

HIV (2)

HSP (1)

HSV (1)

Huntingtin (2)

IKK (1)

Influenza Virus (2)

Interleukin Related (1)

Isotope-Labeled Compounds (14)

MDM-2/p53 (2)

Microtubule/Tubulin (7)

Mitochondrial Metabolism (2)

Mitophagy (1)

MOFs (1)

mTOR (4)

N-myristoyltransferase (1)

Na+/K+ ATPase (3)

nAChR (6)

Necroptosis (2)

NF-κB (3)

Nucleoside Antimetabolite/Analog (2)

P-glycoprotein (3)

p38 MAPK (2)

Paraptosis (2)

Parasite (324)

PARP (4)

PDGFR (1)

Phosphatase (10)

Phosphodiesterase (PDE) (3)

Phytohormone (2)

PI3K (3)

PI4K (3)

PKA (4)

PKC (2)

Potassium Channel (4)

PROTACs (1)

Proteasome (4)

PTEN (2)

Pyroptosis (2)

RAD51 (2)

Reactive Oxygen Species (ROS) (15)

Reference Standards (34)

SARS-CoV (3)

Ser/Thr Kinase (1)

STAT (3)

Succinate Dehydrogenase (1)

TMV (1)

Topoisomerase (2)

Transmembrane Glycoprotein (1)

TrxR (1)

VEGFR (2)

By Research Areas:

Cancer (45)

Cardiovascular Disease (3)

Endocrinology (1)

Infection (327)

Inflammation/Immunology (26)

Metabolic Disease (9)

Neurological Disease (7)

348

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18062

Pyrimethamine 10+ Cited Publications Pirimecidan; Pirimetamin; RP 4753	Antifolate Parasite	Infection Cancer
Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate .

HY-143218

TPE-MI 10+ Cited Publications Tetraphenylethene maleimide	Huntingtin Parasite	Infection Neurological Disease
TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasites Plasmodium falciparum .

HY-B0294

Flubendazole 5+ Cited Publications	Parasite Microtubule/Tubulin STAT MDM-2/p53 Apoptosis Autophagy	Infection Cancer
Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal *parasites* .

HY-B0148

Risedronic acid 2 Publications Verification Risedronate	Parasite Apoptosis	Infection Metabolic Disease Cancer
Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to *parasite* proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC₅₀ of 20.3 μM) .

HY-103397

Nanaomycin A 4 Publications Verification	Antibiotic DNA Methyltransferase Parasite	Infection Cancer
Nanaomycin A is the first selective DNMT3B inhibitor with an IC₅₀ of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells . Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC₈₀ value of 33.1 nM .

HY-141519

PI-55	Parasite	Infection
PI-55 is a specific cytokinin receptor inhibitor. PI-55 is structurally related to 6-benzylaminopurine (BAP) and was shown to inhibit competitively BAP binding on Arabidopsis-specific receptors CRE1/AHK4 and AHK3. PI-55 inhibits cytokinins induced haustorium formation and increased parasite aggressiveness .

HY-B0175

Toltrazuril 3 Publications Verification BAY-i 9142	Parasite Antibiotic	Infection
Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites.

HY-107496

Imidocarb dipropionate 1 Publications Verification	Parasite Antibiotic	Infection
Imidocarb dipropionate is a potent antiprotozoal agent. Imidocarb dipropionate is active against the parasite B. bovis with an IC₅₀ of 87 μg/mL .

HY-151561

WM382	Parasite	Infection
WM382 is an orally active and potent dual plasmepsin IX/X (PMIX/X) inhibitor with IC₅₀ values of 1.4 nM and 0.03 nM, respectively. WM382 has robust in vivo efficacy at multiple stages of the malaria parasite life cycle and an excellent resistance profile .

HY-17592A

Bithionol (sulfoxide) 2 Publications Verification	Parasite	Infection
Bithionol sulfoxide is an anti-infection agent for *parasites. Bithionol sulfoxide has mutagenic activity. Bithionol sulfoxide can be used in the research of parasite* infection, such as paragonimiasis, flukes andcestodes infection .

HY-101397

Allopurinol riboside 2 Publications Verification	Parasite Drug Metabolite Endogenous Metabolite	Infection
Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.

HY-116392B

DL-threo-PDMP hydrochloride	Glucosylceramide Synthase (GCS) Parasite	Infection Endocrinology Cancer
DL-threo-PDMP hydrochloride is a competitive glucosylceramide synthase (GCS) inhibitor and antimalarial agent. DL-threo-PDMP hydrochloride competitively inhibits the activity of GCS. DL-threo-PDMP hydrochloride restores cisplatin sensitivity in cisplatin-resistant testicular germ cell tumor cells. DL-threo-PDMP hydrochloride blocks the growth of ring-stage Plasmodium falciparum parasites .

HY-108024A

Ganaplacide hydrochloride KAF156 hydrochloride; GNF156 hydrochloride	Parasite	Infection
Ganaplacide (KAF156) hydrochloride is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide hydrochloride is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide hydrochloride is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite .

HY-135611

Imidocarb 1 Publications Verification	Parasite Antibiotic	Infection
Imidocarb is a potent antiprotozoal agent. Imidocarb is active against the parasite B. bovis with an IC₅₀ of 87 μg/mL .

HY-176707

GSK2181306A	Parasite	Infection
GSK2181306A is a pan-FIKK inhibitor with an EC₅₀ value of 0.16 μM for parasite growth inhibition. GSK2181306A can be used to study Plasmodium infection .

HY-W013111

2′-Deoxy-GDP trisodium dGDP trisodium; 2'-Deoxyguanosine-5'-diphosphate trisodium	Nucleoside Antimetabolite/Analog Parasite	Infection
2′-Deoxy-GDP (dGDP) trisodium, a guanosine monophosphate (GMP) analogue, is a hypoxanthine phosphoribosyltransferase (HGPRT) inhibitor with an IC₅₀ of 12.5 μM. HGPRT is a central enzyme in the purine recycling pathway of all protozoan parasites .

HY-120060

GNF6702	Parasite	Infection
GNF6702 is a selective inhibitor of the kinetoplastid proteasome. GNF6702 clears parasites in murine models of leishmaniasis, Chagas disease, and human African trypanosomiasis .

HY-136637

NPD-001	Phosphodiesterase (PDE) Parasite	Infection
NPD-001 is a potent Trypanosoma brucei phosphodiesterases 1/2 (TbrPDEB1/2) inhibitor, with IC₅₀ values of 4 and 3 nM, respectively. NPD-001 also inhibits hPDE4. NPD-001 can increase cAMP levels in parasites, prevent cytokinesis, and cause the parasites to form multinucleated, multi-flagellated cells that eventually lyse. NPD-001 can be used for the research of infection .

HY-12607

ML251	Parasite	Infection
ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC₅₀=0.37 μM) and T. cruzi PFK (IC₅₀=0.13 μM). ML251 can be used for the research of parasite .

HY-101725

Meclonazepam Ro 11-3128; Ro 11-3128/002	Parasite	Infection Neurological Disease
Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect . Meclonazepam is active against immature S. mansoni. Meclonazepam (30 μM) eliminates 100% of immature parasites. Meclonazepam has a anti-schistosomal effect .

HY-117015

Purfalcamine	Parasite	Infection
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC₅₀ of 17 nM and an EC₅₀ of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage .

HY-129959

Aluminum phthalocyanine chloride AlClPc	Environmental Pollutants Parasite MOFs	Infection
Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .

HY-W765152

epi-Ivermectin B1a 22,23-Dihydro avermectin B1a; epi-Dihydro avermectin B1a	Parasite	Infection
epi-Ivermectin B1a is a key related substance of Ivermectin (HY-15310), primarily existing as a process-related impurity or potential degradation product in ivermectin-based antiparasitic formulations. epi-Ivermectin B1a can be used for the study of internal/external parasites in cattle .

HY-170780

DSM1465	Parasite Dihydroorotate Dehydrogenase	Infection
DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC₅₀ value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC₅₀ value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model .

HY-138075

Obafluorin	Antibiotic Bacterial Parasite	Infection
Obafluorin is a β-lactone antibiotic. Obafluorin inhibits threonyl-tRNA synthetase (PfThrRS) with an IC₅₀ of 4.3 nM. Obafluorin inhibits the aminoacylation activity of EcThrRS and ObaO. Obafluorin exhibits Fe ³⁺-enhanced antibacterial activity. Obafluorin can be used in studies related to infections caused by bacterial and *parasites* such as Plasmodium .

HY-N10928

Lettowienolide	Parasite	Infection
Lettowienolide, a geranylbenzoquinonoid, exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite (IC₅₀~20 μg/mL) .

HY-132170

DSM502	Dihydroorotate Dehydrogenase Parasite	Infection
DSM502 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM502 exhibits nanomolar potency againsts Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs .

HY-N10096

Epoxyazadiradione	Parasite	Infection
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .

HY-W049875

Nitroxynil	Parasite	Infection
Nitroxynil, anthelmintic agent, is active against parasites in both adult and immature stages. Nitroxynil is widely used for the research of infection of Fasciola hepatica .

HY-132171A

DSM705 hydrochloride	Dihydroorotate Dehydrogenase Parasite	Infection
DSM705 hydrochloride, an orally active antimalarial compound, is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 hydrochloride exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites (IC₅₀=95, 52 nM for P. falciparum and P. vivax DHODH, respectively), with no inhibition of mammalian DHODHs .

HY-151485

Anti-infective agent 5	Parasite	Infection
Anti-infective agent 5 (compound 74) is an orally active inhibitor of *Trypanosoma cruzi* with an IC₅₀ value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection .

HY-136307S

Tizoxanide-d4 glucuronide	Isotope-Labeled Compounds Parasite	Infection
Tizoxanide-d₄ glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum .

HY-W973644

LY-266500	Mitochondrial Metabolism Parasite	Infection
LY-266500 is a succinyl CoA synthetase (SCS) specific inhibitor. LY-266500 has inhibitory effects on various parasites, such as Trypanosoma brucei brucei (IC₅₀ =0.6 μM) and Leishmania donovani (IC₅₀ =2.86 μM). LY-266500 can be used for research on parasitic infections .

HY-18062R

Pyrimethamine (Standard) Pirimecidan (Standard); Pirimetamin (Standard); RP 4753 (Standard)	Reference Standards Antifolate Parasite	Infection
Pyrimethamine (Standard) is the analytical standard of Pyrimethamine. This product is intended for research and analytical applications. Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate .

HY-B0294R

Flubendazole (Standard)	Reference Standards Parasite Microtubule/Tubulin STAT MDM-2/p53 Apoptosis Autophagy	Infection Cancer
Flubendazole (Standard) is the analytical standard of Flubendazole. This product is intended for research and analytical applications. Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal *parasites* .

HY-108387

Morantel citrate	Parasite	Infection
Morantel citrate is a veterinary anthelmintic agent that inhibits parasitic infections in cattle, sheep and goats. Morantel citrate paralyzes the nervous system of the parasite, helping the animal expel the dead parasite from the body .

HY-108024

Ganaplacide KAF156; GNF156	Parasite	Infection
Ganaplacide (KAF156) is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite .

HY-14830

SAR 97276 Albitiazolium bromide	Parasite	Infection
SAR 97276 (Albitiazolium bromide) is an antimalarial agent. SAR 97276 interfers with the phospholipid metabolism of malarial parasites, especially the biosynthesis of phosphatidylcholine (PC). SAR 97276 enters erythrocytes through the new permeability pathways (NPP) of infected erythrocytes, and is transported into the malarial parasite by a poly-specific cation carrier .

HY-P3425

AGPV	Parasite	Infection
AGPV, a tetrapeptide, has the potential for prevention of schistosome parasite infection research .

HY-132171

DSM705	Dihydroorotate Dehydrogenase Parasite	Infection
DSM705 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs. DSM705 is a potent antimalarial compound .

HY-107496R

Imidocarb dipropionate (Standard)	Reference Standards Parasite Antibiotic	Infection
Imidocarb (dipropionate) (Standard) is the analytical standard of Imidocarb (dipropionate). This product is intended for research and analytical applications. Imidocarb dipropionate is a potent antiprotozoal agent. Imidocarb dipropionate is active against the parasite B. bovis with an IC50 of 87 μg/mL .

HY-174342

ELQ-453	Cytochrome P450 Parasite	Infection
ELQ-453 is an inhibitor targeting the Q_o site of the Plasmodium falciparum cytochrome bc1 complex (CytB) with an IC₅₀ value of 0.57 nM. ELQ-453 blocks the mitochondrial function of the parasite, and suppresses Plasmodium infection in mosquitoes. ELQ-453 is promising for research of malaria .

HY-175345

CYP3A4-IN-5	Parasite	Infection
CYP3A4-IN-5 (Compound 5p) is a potent Leishmania major pteridine reductase 1 (Lm PTR1) inhibitor (IC₅₀=12.77 µM). CYP3A4-IN-5 is promising for research of parasite infection .

HY-103397R

Nanaomycin A (Standard)	Antibiotic Reference Standards DNA Methyltransferase Parasite	Infection Cancer
Nanaomycin A (Standard) is the analytical standard of Nanaomycin A. This product is intended for research and analytical applications. Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells[1]. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[2].

HY-121493

TM2-115	Histone Methyltransferase Parasite	Infection
TM2-115 inhibits malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death .

HY-W104379

Arprinocid	Parasite	Infection
Arprinocid is a purine analog with activity against murine Toxoplasma gondii .

HY-P3451

Lefleuganan	Parasite	Infection
Lefleuganan is a potent antiprotozoal agent .

HY-N15321

Norselic acid B	Parasite	Infection Inflammation/Immunology
Norselic acid B is a natural compound that can be isolated from the sponge Crella sp. collected in Antarctica. T. Norselic acid B is active against the Leishmania parasite .

HY-155549

Antileishmanial agent-20	Parasite	Infection
Antileishmanial agent-20 is selective towards Leishmania *parasite. Antileishmanial agent-20 has IC₅₀* value of 2.8 μM and 0.2 μM for L. infantum and L. braziliensis, respectively. Antileishmanial agent-20 can be used for parasites research .

HY-172131

Emoquine-1	Parasite	Infection
Emoquine-1 is an orally active and potent antimalarial drug. Emoquine-1 is efficient against multidrug-resistant Plasmodium parasites, including the Artemisinin-resistant quiescent stage. Emoquine-1 is active against proliferative P. falciparum with IC₅₀ values of 20-55 nM. Emoquine-1 is a candidate to fight Plasmodium parasites resistant to artemisinin-based combination therapies (ACTs) with a capacity to eliminate persistent parasites .

Cat. No.	Product Name

HY-L002

Anti-Infection Compound Library

4,238 compounds

An infection occurs when another organism enters a person’s body and causes disease. The organisms that cause infections are very diverse and can include things like viruses, bacteria, fungi, and parasites. The immune system is an effective barrier against infectious agents.

MCE provides a unique collection of 4,238 anti-infective compounds with anti-bacterial, anti-viral, anti-fungal and anti-parasite activities that can be used for drug screening and other research in anti-microbial area.

HY-L082

Antiparasitic Compound library

637 compounds

A parasite is an organism that lives on or in a host organism and gets its food from or at the expense of its host. Parasites of humans include protozoans, helminths, and ecto-parasites (organisms that live on the external surface of a host). They are responsible for many diseases and are transmitted to their hosts most often through the ingestion of contaminated food, water or through the bite of an arthropod (e.g., a fly or tick), which can act as an intermediate host and as a vector. Parasitic diseases of humans are a major global health problem causing significant morbidity and mortality, especially in developing countries. Each year there are hundreds of millions of people infected with disease-causing parasites, particularly in tropical and subtropical regions of the world, resulting in an estimated one million deaths. Therefore, there is a dire need of novel anti-parasitic drugs.

MCE has a unique collection of 637 compounds with validated anti-parasitic activity which offer researchers an opportunity to screen novel anti-parasitic targets.

Cat. No.	Product Name	Type

HY-143218

TPE-MI

10+ Cited Publications

Tetraphenylethene maleimide

Fluorescent Dye

TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasites Plasmodium falciparum .

HY-D0952

Acridine Orange base

35+ Cited Publications

Fluorescent Dye

Acridine Orange base is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc.) bright orange and, when used under appropriate conditions (pH=3.5, Ex=460 nm), distinguishes human cells in green for detection by fluorescence microscopy. Acridine Orange base fluoresces green when bound to dsDNA (Ex=488, Em=520-524) and red when bound to ssDNA (Ex=457, Em=630-644) or ssRNA (Ex=457, Em=630-644), also can be used in cell cycle assays .

HY-129959

Aluminum phthalocyanine chloride

AlClPc

Fluorescent Dye

Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .

HY-DY1024

TPE-MI (solution)

Fluorescent Dye

TPE-MI (Tetraphenylethene maleimide) (solution) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum .
Solvent and concentration: DMSO: 10 mM

HY-D1532

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS	Fluorescent Dye
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite .

Cat. No.	Product Name	Type

HY-D0008

Brilliant green	Biochemical Assay Reagents
Brilliant green is a cationic dye used to color silk and wool. Brilliant green inhibits propagation of mold, intestinal *parasites* and fungus. Brilliant green is effective against Gram-positive bacteria .

HY-W104379

Arprinocid	Biochemical Assay Reagents
Arprinocid is a purine analog with activity against murine Toxoplasma gondii .

Cat. No.	Product Name	Target	Research Area

HY-P3425

AGPV	Parasite	Infection
AGPV, a tetrapeptide, has the potential for prevention of schistosome parasite infection research .

HY-P3451

Lefleuganan	Parasite	Infection
Lefleuganan is a potent antiprotozoal agent .

HY-P3425A

AGPV TFA	Parasite	Infection
AGPV TFA, a tetrapeptide, has the potential for prevention of schistosome parasite infection research .

HY-D1532

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS	Parasite	Others
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite .

HY-P5344

Dabcyl-LNKRLLHETQ-Edans Fluorigenic PEXEL peptide	Parasite	Others
Dabcyl-LNKRLLHETQ-Edans (Fluorigenic PEXEL peptide) is a biological active peptide. (This FRET substrate peptide for Plasmepsin V (PMV) is derived from the conserved Plasmodium Export Element (PEXEL) motif of Histidine-Rich Protein II (HRPII). PMV is an ER aspartic protease that recognizes and cleaves the RXL sequence within the PEXEL motif of proteins exported by human malaria parasite Plasmodium falciparum, allowing them to translocate into host erythrocytes.)

HY-P0263A

Dermaseptin TFA	Bacterial Fungal	Infection
Dermaseptin TFA, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration .

HY-P2209

Nummularine B Daechuine S27; N-Demethylamphibine H	Parasite Phosphodiesterase (PDE)	Infection
Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca ²⁺-ATPase. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990212

Anti-Mouse IL-6 Antibody (MP5-20F3) 1 Publications Verification	Interleukin Related STAT	Infection Inflammation/Immunology
Anti-Mouse IL-6 Antibody (MP5-20F3) is an anti-mouse IL-6 IgG1 monoclonal antibody. Anti-Mouse IL-6 Antibody (MP5-20F3) reshapes the tumor microenvironment by blocking IL-6. Anti-Mouse IL-6 Antibody (MP5-20F3) can inhibit the STAT3 pathway and enhance T cell infiltration. Anti-Mouse IL-6 Antibody (MP5-20F3) can be used for researches on inflammation and infection conditions such as malignant pleural effusion (MPE) .

HY-P990804

Anti-Mouse NKG2D/CD314 Antibody (HMG2D)	Transmembrane Glycoprotein	Infection Inflammation/Immunology Cancer
Anti-Mouse NKG2D/CD314 Antibody (HMG2D) is an Armenian hamster-derived IgG antibody inhibitor, targeting to mouse NKG2D/CD314. Anti-Mouse NKG2D/CD314 Antibody (HMG2D) can block NKG2D. Anti-Mouse NKG2D/CD314 Antibody (HMG2D) can be used for the researches of cancer, infection, inflammation and immunology, such as B16F10 tumor, colitis and L. major parasites and lymphocytic choriomeningitis virus (LCMV) co-infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15310

Ivermectin Maximum Cited Publications 48 Publications Verification MK-933; CD-5024; K-237	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antiviral Anti-parasitic Disease Research Disease Research Fields Source Classification Cancer	Environmental Pollutants Antibiotic Mitophagy Bacterial Parasite Autophagy Flavivirus HSV HIV SARS-CoV Dengue Virus
Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

HY-D0143

Quinine 5+ Cited Publications	Cinchona succirubra Pav. ex Klotzsch Infection Alkaloids Classification of Application Fields Rubiaceae Quinoline Alkaloids Plants Disease Research Fields Source Classification	Flavivirus Dengue Virus Parasite Potassium Channel
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-W071746

Linolelaidic acid 1 Publications Verification Linoelaidic acid	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Parasite Apoptosis
Linolelaidic acid (Linoelaidic acid) is an omega-6 trans fatty acid (TFA) that is an essential nutrient with oral activity. Linolelaidic acid can be added to enteral nutrition (oral), parenteral nutrition (intravenous), and infant formula. Linolelaidic acid has anti-inflammatory and anti-parasitic ((Parasite)) activities, and can induce Apoptosis. Linolelaidic acid is useful for research in infections .

HY-15311

Avermectin B1 5 Publications Verification Abamectin; Avermectin B1a-Avermectin B1b mixt.	Structural Classification Classification of Application Fields Anti-parasitic Antibacterial Disease Research Biological Pesticide Research Agricultural Research Infection Microorganisms Macrolide Antibiotics Antibiotics Animal Husbandry Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Autophagy Parasite Apoptosis Reactive Oxygen Species (ROS)
Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy .

HY-N0281

Daphnetin 5+ Cited Publications 7,8-Dihydroxycoumarin	Daphne Classification of Application Fields Thymelaeaceae Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1β, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

HY-N0841

Bruceine A 3 Publications Verification Dihydrobrusatol; NSC310616	Infection Triterpenes Simaroubaceae Classification of Application Fields Terpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Source Classification	Parasite NF-κB p38 MAPK Phosphatase Apoptosis
Bruceine A (Dihydrobrusatol) is a natural quassinoid. Bruceine A is an inhibitor of *parasites, NF-κB, and PFKFB4* (K_d: 44 nM). Bruceine A is an activator of P38α MAPK. Bruceine A has antiparasitic activity. Bruceine A has antitumor activity and inhibits cancer cell migration. Bruceine A blocks the cell cycle and induces apoptosis. Bruceine A can be used in parasites, pancreatic cancer, and breast cancer research .

HY-N6950

Hederacolchiside A1 1 Publications Verification	Infection Triterpenes other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification	PI3K Akt mTOR Parasite Apoptosis
Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway . Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro .

HY-N3980

Guaiol 1 Publications Verification Champacol; Guaiac alcohol	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Distemonanthus benthamianus Baill. Plants Compositae Disease Research Fields Source Classification	Autophagy RAD51
Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC₅₀ of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions ^[4]

HY-101397

Allopurinol riboside 2 Publications Verification	Infection Alkaloids Classification of Application Fields Endogenous metabolite Disease Research Fields Indole Alkaloids Source Classification	Parasite Drug Metabolite Endogenous Metabolite
Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.

HY-129476

L-Canaline	Infection other families Classification of Application Fields Amino acids Plants Endogenous metabolite Disease Research Fields Source Classification	Parasite Endogenous Metabolite
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects .

HY-169790

Phomarin	Plantaginaceae Digitalis purpurea L. Quinones Structural Classification Anthraquinones Plants Source Classification	Dihydrofolate reductase (DHFR) Parasite Fungal
Phomarin is an inhibitor for dihydrofolate reductase (DHFR). Phomarin exhibits activity against Plasmodium *parasites* and fungi including Mycrobotryum violaceum and Botrytis cinerea. Phomarin can be used for the research of malaria and fungal infections .

HY-D0143B

Quinine hemisulfate hydrate 5+ Cited Publications	Infection Alkaloids Classification of Application Fields Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields Source Classification	Parasite Potassium Channel
Quinine hemisulfate hydrate, an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV, with an IC₅₀ of 169 μM .

HY-N10534

Lewis X trisaccharide Lewis X	Infection Structural Classification Polysaccharides Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Saccharides Cancer	Parasite
Lewis X trisaccharide (Lewis X, Le ^x) is a potent T_H2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .

HY-111759

Jaspamycin 1 Publications Verification 7-CN-7-C-Ino	Marine natural products Source Classification	PKA Parasite
Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC₅₀ of 6.5 nM and K_d of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. *Anti-parasite* activity .

HY-N12788

T-Cadinol	Citrus × aurantium Natsudaidai Terpenoids Sesquiterpenes Plants Salicaceae Source Classification	Parasite
T-Cadinol is a sesquiterpene isolated from C. sylvestris that exhibits anti-Trypanosoma cruzi activity, with IC₅₀ values of 18.2 μM and 15.8 μM against trypomastigote and amastigote forms, respectively. T-Cadinol can induce mitochondrial damage in parasites, leading to membrane hyperpolarization and decreased levels of reactive oxygen species. T-Cadinol can be used for the research of Chagas disease .

HY-N10928

Lettowienolide	Quinones Stellaria media (L.) Villars Phenols Benzene Quinones Plants Caryophyllaceae Source Classification	Parasite
Lettowienolide, a geranylbenzoquinonoid, exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite (IC₅₀~20 μg/mL) .

HY-N10096

Epoxyazadiradione	Infection Triterpenes other families Classification of Application Fields Terpenoids Plants Disease Research Fields Biological Pesticide Research Agricultural Research Source Classification	Parasite
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .

HY-N15245

(+)-Sorgomol	Natural Products Sorghum bicolor (Linn.) Moench Gramineae Plants Source Classification	Phytohormone
(+)-Sorgomol is the plants hormone that can be isolated from Sorghum bicolor. (+)-Sorgomol is the germination stimulant for plants, which induces seed germination of root parasites .

HY-N9320

13,21-Dihydroeurycomanone	Infection other families Classification of Application Fields Ketones, Aldehydes, Acids Eurycoma longifolia Jack Plants Disease Research Fields Source Classification	Parasite
13,21-Dihydroeurycomanone, a natural compound isolated from Eurycoma longifolia root, possesses anti-parasite activity for Plasmodium falciparum and Toxoplasma gondii .

HY-N2656

5,7,8-Trimethoxycoumarin	Zanthoxylum dimorphophyllum Hemsl. Rutaceae Coumarins Phenylpropanoids Plants	Parasite
5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC₅₀s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively .

HY-N2927

Costic acid β-Costic acid	Ketones, Aldehydes, Acids Plants Compositae Source Classification Desmodium sandwicense	Parasite
Costic acid (β-Costic acid) is a natural product, that can be isolated from Dittrichia viscosa. Costic acid exhibits potent in vivo acaricidal activity against the *parasite*. Costic acid is not toxic for human umbilical vein endothelial cells (HUVEC) at concentrations of up to 230 μM. Costic acid can be used for the research of varroosis in honey bee colonies .

HY-N1074

Warangalone Scandenolone	Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones Source Classification Erythrina variegata Linn.	Parasite PKA
Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC₅₀s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC₅₀ of 3.5 μM.

HY-W071746R

Linolelaidic acid (Standard) Linoelaidic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Parasite Apoptosis
Linolelaidic acid (Standard) is the analytical standard of Linolelaidic acid. This product is intended for research and analytical applications. Linolelaidic acid (Linoelaidic acid) is an omega-6 trans fatty acid (TFA) that is an essential nutrient with oral activity. Linolelaidic acid can be added to enteral nutrition (oral), parenteral nutrition (intravenous), and infant formula. Linolelaidic acid has anti-inflammatory and anti-parasitic ((Parasite)) activities, and can induce Apoptosis. Linolelaidic acid is useful for research in infections[1][2][3].

HY-N16392

14-epi-Berkeleylactone F	Natural Products Microorganisms Source Classification	Endogenous Metabolite
14-epi-Berkeleylactone F (Compound 8) is a C-14 epimer of Berkeleylactone F (HY-N8386). 14-epi-Berkeleylactone F can be isolated from Penicillium turbatum NRRL 5630. 14-epi-Berkeleylactone F has no significant biological activity against bacterium (Staphylococcus aureus, Bacillus subtilis and E. coli), fungi Candida albicans, the parasite Giardia duodenalis and NS-1 murine myeloma cells .

HY-N9991

5-Hydroxy-3,7-dimethoxyflavone	Kaempferia parviflora Wall. ex Baker Plants Source Classification Zingiberaceae	Parasite
5-Hydroxy-3,7-dimethoxyflavone (compound 1) can be isolated from Kaempferia parviflora, but has no significant toxicity to malaria parasites, fungi, and bacteria .

HY-D0143R

Quinine (Standard)	Cinchona succirubra Pav. ex Klotzsch Alkaloids Structural Classification Rubiaceae Quinoline Alkaloids Plants Source Classification	Dengue Virus Flavivirus Reference Standards Parasite Potassium Channel
Quinine (Standard) is the analytical standard of Quinine. This product is intended for research and analytical applications. Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-N8707

Homobutein	Classification of Application Fields Plants Compositae Infection Chalcones Flavonoids Millettia pachyloba Drake Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification Cancer	Parasite HDAC NF-κB
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC₅₀s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation .

HY-N6950R

Hederacolchiside A1 (Standard)	Triterpenes Structural Classification other families Terpenoids Plants Source Classification	Reference Standards PI3K Akt mTOR Parasite Apoptosis
Hederacolchiside A1 (Standard) is the analytical standard of Hederacolchiside A1. This product is intended for research and analytical applications. Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway . Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro .

HY-15311R

Avermectin B1 (Standard) Abamectin (Standard); Avermectin B1a-Avermectin B1b mixt. (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Animal Husbandry Anti-parasitic Antibacterial Disease Research Source Classification	Reference Standards Parasite Autophagy Apoptosis Reactive Oxygen Species (ROS) Antibiotic
Avermectin B1 (Standard) is the analytical standard of Avermectin B1. This product is intended for research and analytical applications. Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and autophagy .

HY-N0281R

Daphnetin (Standard) 7,8-Dihydroxycoumarin (Standard)	Structural Classification Daphne Thymelaeaceae Coumarins Phenols Polyphenols Phenylpropanoids Plants Source Classification	Reference Standards EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite
Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

HY-N15321

Norselic acid B	Ketones, Aldehydes, Acids Marine natural products Sponge Source Classification	Parasite
Norselic acid B is a natural compound that can be isolated from the sponge Crella sp. collected in Antarctica. T. Norselic acid B is active against the Leishmania parasite .

HY-N8513

Brevicompanine B	Infection Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Parasite
Brevicompanine B, a diketopiperazine alkaloid, is an antiplasmodial agent. Brevicompanine B is active against the malaria parasite Plasmodium falciparum 3D7 IC₅₀ of 35 mg/mL .

HY-N10624

Koshidacin B	Natural Products Microorganisms	Parasite
Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against *P. falciparum* FCR3 and K1 strain with IC₅₀ values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection .

HY-N10197

Pulixin	Infection Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Coumarins Phenols Polyphenols Phenylpropanoids Disease Research Fields Source Classification	Parasite Endogenous Metabolite
Pulixin prevents FREP1 from binding to P. falciparum-infected cell lysate. Pulixin blocks the transmission of the parasite to mosquitoes with an EC₅₀ of 11 µM. Pulixin also inhibits the proliferation of asexual-stage P. falciparum with an EC₅₀ of 47 nM .

HY-N8521

6-O-Methacrylate	Infection Natural Products other families Classification of Application Fields Plants Disease Research Fields Source Classification	TMV Parasite
6-O-Methacrylate, a trilobolide, is isolated from the leaves of Wedelia trilobata. 6-O-Methacrylate displays marked antimalarial activity, with IC₅₀ of 8.9 μg/mL against P. falciparum parasite. 6-O-Methacrylate also has anti-tobacco mosaic virus (TMV) activity .

HY-N12538

trans-Cinnamic anhydride	Natural Products Cinnamomum verum J. Presl Plants Lauraceae Source Classification	Parasite
trans-Cinnamic anhydride is a *Parasite* inhibitor tnat can be isolated from Cinnamomum zeylanicum and exhibits moderate activity against Plasmodium falciparum .

HY-N15244

(+)-Strigone	Natural Products Saururaceae Houttuynia cordata Thunb. Plants Source Classification	Phytohormone
(+)-Strigone is a phytohormone that can be isolated from Houttuynia cordata. (+)-Strigoneis is the germination stimulant for plants, which induces seed germination of root parasites .

HY-N9179

3′,4′,5′,5,6,7-Hexamethoxyflavone	Infection Flavonoids Classification of Application Fields Flavones Lupinus perennis L. Plants Compositae Disease Research Fields Source Classification	Parasite
3′,4′,5′,5,6,7-Hexamethoxyflavone is a flavonoid with antiprotozoal activity. 3′,4′,5′,5,6,7-Hexamethoxyflavone inhibits trypanosoma bruceirhodesiense with IC₅₀ of 21.3 μM (8.58 g/mL) .

HY-136438

Toltrazuril sulfoxide 1 Publications Verification	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite Parasite
Toltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril (HY-B0175), and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites .

HY-N11550

Salviandulin E	Artemisia frigida Willd. Terpenoids Labiatae Diterpenoids Plants Source Classification	Parasite
Salviandulin E is a diterpenoid compound that can be isolated from Salvia leucantha CAV.. Salviandulin E shows antitrypanosomal activity against **T. b. brucei GUTat 3.1 parasites with an IC₅₀** value of 0.72 µg/mL .

HY-N8181

1,3-Linolein-2-Olein	Infection Structural Classification Classification of Application Fields Campanulaceae Plants Codonopsis thalictrifoliaWall. Disease Research Fields Lipid Source Classification	Parasite
1,3-Linolein-2-Olein, a triglyceride, is an antileishmanial agent. 1,3-Linolein-2-Olein inhibits promatigotes of the parasite (IC₅₀=0.079 ug/ml) and inhibits the growth of amastigotes (IC₅₀= 40.03 ug/ml) .

HY-136438R

Toltrazuril sulfoxide (Standard)	Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Parasite
Toltrazuril sulfoxide (Standard) is the analytical standard of Toltrazuril sulfoxide. This product is intended for research and analytical applications. Toltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril (HY-B0175), and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites .

HY-N10441

3β-Hydroxy-hop-22(29)-ene	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Euphorbiaceae Plants Source Classification	Parasite
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana .

HY-N3980R

Guaiol (Standard) Champacol (Standard); Guaiac alcohol (Standard)	Structural Classification Natural Products Distemonanthus benthamianus Baill. Plants Compositae Source Classification	Reference Standards Autophagy RAD51
Guaiol (Standard) is the analytical standard of Guaiol. This product is intended for research and analytical applications. Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions [4]

HY-P2209

Nummularine B Daechuine S27; N-Demethylamphibine H	Structural Classification Alkaloids Other Alkaloids Plants Actaea simplex (DC.) Wormsk. ex Fisch. & C. A. Mey. Rhamnaceae Source Classification	Parasite Phosphodiesterase (PDE)
Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca ²⁺-ATPase. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .

Cat. No.	Product Name	Chemical Structure

HY-B0777S

Moxidectin-d3

Moxidectin-d₃ (CL-301423-d₃) is deuterium labeled Moxidectin. Moxidectin (CL301423) is an orally active macrolide (ML) anthelmintic for the prevention and control of heartworms and roundworms. Moxidectin is also a substrate of BCRP and P-glycoprotein (P-gp) in vivo, and is secreted into breast milk and effluxed from the host and parasite mediated by Bcrp1 and P-gp. This may be related to the presence of chemical residues in milk .

HY-B0537AS

Pentamidine-d4 dihydrochloride

Pentamidine-d₄ (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC₅₀ of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

HY-136307S

Tizoxanide-d4 glucuronide
Tizoxanide-d₄ glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum .

HY-B0148S

Risedronic acid-d4

Risedronic acid-d₄ (Risedronate-d₄) is the deuterium labeled Risedronic acid (HY-B0148). Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC₅₀ of 20.3 μM) .

HY-B0223S2

Albendazole-d7
Albendazole-d₇ is the deuterium labeled Albendazole. Albendazole is a broad-spectrum parasiticide with high effectiveness and low host toxicity. Albendazole is used for the research gastrointestinal parasites in humans and animals .

HY-12785S1

Albendazole sulfoxide-d7
Albendazole sulfoxide-d₇ is the deuterium labeled Albendazole sulfoxide. Albendazole sulfoxide (Ricobendazole), the main active metabolite of Albendazole, exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes .

HY-B0175S

Toltrazuril-d3
Toltrazuril-d₃ is deuterated labeled Toltrazuril. Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites.

HY-13832S2

Atovaquone-d5

Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome?bc1?complex. Atovaquone is against human and ?P. falciparum?cytochrome?bc1?activity with IC₅₀ values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .

HY-17598S

Rafoxanide-13C6
Rafoxanide ¹³C₆ is a labeled Rafoxanide (HY-17598). Rafoxanide is a salicylanilide used as an antiparasitic agent .

HY-13832S3

cis-Atovaquone-d4

cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-W019773S1

Albendazole sulfone-d3
Albendazole sulfone-d₃ is the deuterium labeled Albendazole sulfone. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.

HY-W019773S

Albendazole sulfone-d7
Albendazole sulfone-d₇ is the deuterium labeled Albendazole sulfone. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes .

HY-B0621S

Triclabendazole-d3
Triclabendazole-d₃ is the deuterium labeled Triclabendazole (HY-B0621). Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica .

HY-B0223S4

Albendazole-d3-1

Albendazole-d₃-1 (SKF-62979-d₃-1) is the deuterium labeled Albendazole (HY-B0223). Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells .

HY-126937S

Ivermectin B1a-d2-1
Ivermectin B1a-d₂-1 is the deuterium labeled Ivermectin B1a (HY-126937). Ivermectin B1a, a derivative of Avermectin B1a (HY-15308), is a main component of Ivermectin (HY-15310) . Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

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