4 Results for "

peptidyl-prolyl cis/trans isomerase activity

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "peptidyl-prolyl cis/trans isomerase activity" in MCE Product Catalog:

1
PIN1 inhibitor API-1
PIN1 inhibitor API-1
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1 Cited Publications
Cat. No.: HY-116716
CAS No.: 680622-70-2
Purity:  98.54%
Target:  

MicroRNA

Research Areas:  

Cancer

PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development .
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Suc-Ala-Leu-Pro-Phe-pNA
Suc-Ala-Leu-Pro-Phe-pNA
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Cat. No.: HY-P4581
CAS No.: 128802-78-8
Synonyms: Suc-ALPF-pNA
Target:  

FKBP

Research Areas:  

Others

Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA) is a synthetic polypeptide substrate that targets FK506-binding protein (FKBP). Suc-Ala-Leu-Pro-Phe-pNA can be used to determine peptidyl-prolyl cis-trans isomerase activity via the chymotrypsin-coupled assay. Suc-Ala-Leu-Pro-Phe-pNA serves as a substrate for human FK506-binding protein hFKBP-12 in the chymotrypsin-FKBP coupled PPIase assay. Suc-Ala-Leu-Pro-Phe-pNA is applicable for the detection and research of PPIase activity .
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SMCypI C31
SMCypI C31
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Cat. No.: HY-125182
CAS No.: 2649904-85-6
Target:  

Cyclophilin HCV

Research Areas:  

Infection

SMCypI C31 is a non-peptidic cyclophilin inhibitor with potent peptidyl-prolyl cis/trans isomerases (PPIase) inhibitory activity (IC50 of 0.1 µM). SMCypI C31 shows pangenotype anti-HCV activity with EC50s ranging from 1.20 to 7.76 μM for genotype 1a, 1b, 2a, 3a, and 5a HCV subgenomic replicons (HCV-SGRs) and chimeric genotype 2a/4a HCV-SGRs. SMCypI C31 disrupts the cyclophilin A-NS5A interaction .
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RN-0001
RN-0001
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Cat. No.: HY-P11489
CAS No.: 252731-57-0
Target:  

Cyclophilin Reactive Oxygen Species (ROS) NF-κB Caspase Apoptosis

Research Areas:  

Metabolic Disease

RN-0001 is a cyclophilin (Cyp) inhibitor with Ki values of 4.1 nM and 12.0 nM against CypA and CypD, respectively, and an EC50 of 916 nM for CypD. RN-0001 binds directly to CypD, inhibits the peptidyl-prolyl cis-trans isomerase activities of CypD and CypA, and prevents CypD-dependent mitochondrial permeability transition pore opening. RN-0001 improves mitochondrial function, reduces ROS production, inhibits the expression of lipogenic markers, blocks the nuclear translocation of NF-κB p65, and decreases the release of activated caspase-3 and cytochrome c. RN-0001 can be used in the research of alcohol-associated liver disease .
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